Exercise Training Attenuates Ovariectomy-Induced Alterations in Skeletal Muscle Remodeling, Apoptotic Signaling, and Atrophy Signaling in Rat Skeletal Muscle
Purpose The effects of aerobic exercise training on soleus muscle morphology, mitochondria-mediated apoptotic signaling, and atrophy/hypertrophy signaling in ovariectomized rat skeletal muscle were investigated. Methods Female Sprague-Dawley rats were divided into control (CON), ovariectomy (OVX), a...
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Korean Continence Society
2021
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oai:doaj.org-article:8fced9389d924c49956d708c74ff06922021-11-30T04:10:47ZExercise Training Attenuates Ovariectomy-Induced Alterations in Skeletal Muscle Remodeling, Apoptotic Signaling, and Atrophy Signaling in Rat Skeletal Muscle2093-47772093-693110.5213/inj.2142334.167https://doaj.org/article/8fced9389d924c49956d708c74ff06922021-11-01T00:00:00Zhttp://www.einj.org/upload/pdf/inj-2142334-167.pdfhttps://doaj.org/toc/2093-4777https://doaj.org/toc/2093-6931Purpose The effects of aerobic exercise training on soleus muscle morphology, mitochondria-mediated apoptotic signaling, and atrophy/hypertrophy signaling in ovariectomized rat skeletal muscle were investigated. Methods Female Sprague-Dawley rats were divided into control (CON), ovariectomy (OVX), and ovariectomy plus exercise (OVX+EX) groups. After ovarian excision, exercise training was performed using a rat treadmill at 20 m/min, 50 min/day, 5 days/week for 12 weeks. Protein levels of mitochondria-mediated apoptotic signaling and atrophy/hypertrophy signaling in the skeletal muscle (soleus) were examined through western immunoblot analysis. Results The number of myocytes and myocyte cross-sectional area (CSA) were increased and the extramyocyte space was decreased in the OVX group compared to those in the CON group. However, aerobic exercise training significantly increased myocyte CSA and decreased extramyocyte space in the OVX+EX group compared to those in the OVX group. The protein levels of proapoptotic signaling and muscle atrophy signaling were significantly increased, whereas the protein levels of muscle hypertrophy signaling were significantly decreased in the OVX group compared to that in the CON group. Aerobic exercise training significantly decreased the protein levels of proapoptotic signaling and increased the protein level of antiapoptotic protein in the OVX+EX group compared to that in the OVX group. Aerobic exercise training significantly increased the protein levels of hypertrophy signaling and decreased protein levels of atrophy signaling in the OVX+EX group compared to those in the OVX group. Conclusions Treadmill exercise improved estrogen deficiency-induced impairment in skeletal muscle remodeling, mitochondria-mediated apoptotic signaling, and atrophy/hypertrophy signaling in skeletal muscle.Eun-Jeong ChoYoungju ChoiJiyeon KimJun Hyun BaeJinkyung ChoDong-Ho ParkJu-Hee KangJin Hwan YoonEunmi ParkDae Yun SeoSukho LeeHyo-Bum KwakKorean Continence Societyarticleestrogenovariectomysarcopeniaexerciseskeletal muscleDiseases of the genitourinary system. UrologyRC870-923ENInternational Neurourology Journal, Vol 25, Iss Suppl 2, Pp S47-54 (2021) |
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estrogen ovariectomy sarcopenia exercise skeletal muscle Diseases of the genitourinary system. Urology RC870-923 |
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estrogen ovariectomy sarcopenia exercise skeletal muscle Diseases of the genitourinary system. Urology RC870-923 Eun-Jeong Cho Youngju Choi Jiyeon Kim Jun Hyun Bae Jinkyung Cho Dong-Ho Park Ju-Hee Kang Jin Hwan Yoon Eunmi Park Dae Yun Seo Sukho Lee Hyo-Bum Kwak Exercise Training Attenuates Ovariectomy-Induced Alterations in Skeletal Muscle Remodeling, Apoptotic Signaling, and Atrophy Signaling in Rat Skeletal Muscle |
description |
Purpose The effects of aerobic exercise training on soleus muscle morphology, mitochondria-mediated apoptotic signaling, and atrophy/hypertrophy signaling in ovariectomized rat skeletal muscle were investigated. Methods Female Sprague-Dawley rats were divided into control (CON), ovariectomy (OVX), and ovariectomy plus exercise (OVX+EX) groups. After ovarian excision, exercise training was performed using a rat treadmill at 20 m/min, 50 min/day, 5 days/week for 12 weeks. Protein levels of mitochondria-mediated apoptotic signaling and atrophy/hypertrophy signaling in the skeletal muscle (soleus) were examined through western immunoblot analysis. Results The number of myocytes and myocyte cross-sectional area (CSA) were increased and the extramyocyte space was decreased in the OVX group compared to those in the CON group. However, aerobic exercise training significantly increased myocyte CSA and decreased extramyocyte space in the OVX+EX group compared to those in the OVX group. The protein levels of proapoptotic signaling and muscle atrophy signaling were significantly increased, whereas the protein levels of muscle hypertrophy signaling were significantly decreased in the OVX group compared to that in the CON group. Aerobic exercise training significantly decreased the protein levels of proapoptotic signaling and increased the protein level of antiapoptotic protein in the OVX+EX group compared to that in the OVX group. Aerobic exercise training significantly increased the protein levels of hypertrophy signaling and decreased protein levels of atrophy signaling in the OVX+EX group compared to those in the OVX group. Conclusions Treadmill exercise improved estrogen deficiency-induced impairment in skeletal muscle remodeling, mitochondria-mediated apoptotic signaling, and atrophy/hypertrophy signaling in skeletal muscle. |
format |
article |
author |
Eun-Jeong Cho Youngju Choi Jiyeon Kim Jun Hyun Bae Jinkyung Cho Dong-Ho Park Ju-Hee Kang Jin Hwan Yoon Eunmi Park Dae Yun Seo Sukho Lee Hyo-Bum Kwak |
author_facet |
Eun-Jeong Cho Youngju Choi Jiyeon Kim Jun Hyun Bae Jinkyung Cho Dong-Ho Park Ju-Hee Kang Jin Hwan Yoon Eunmi Park Dae Yun Seo Sukho Lee Hyo-Bum Kwak |
author_sort |
Eun-Jeong Cho |
title |
Exercise Training Attenuates Ovariectomy-Induced Alterations in Skeletal Muscle Remodeling, Apoptotic Signaling, and Atrophy Signaling in Rat Skeletal Muscle |
title_short |
Exercise Training Attenuates Ovariectomy-Induced Alterations in Skeletal Muscle Remodeling, Apoptotic Signaling, and Atrophy Signaling in Rat Skeletal Muscle |
title_full |
Exercise Training Attenuates Ovariectomy-Induced Alterations in Skeletal Muscle Remodeling, Apoptotic Signaling, and Atrophy Signaling in Rat Skeletal Muscle |
title_fullStr |
Exercise Training Attenuates Ovariectomy-Induced Alterations in Skeletal Muscle Remodeling, Apoptotic Signaling, and Atrophy Signaling in Rat Skeletal Muscle |
title_full_unstemmed |
Exercise Training Attenuates Ovariectomy-Induced Alterations in Skeletal Muscle Remodeling, Apoptotic Signaling, and Atrophy Signaling in Rat Skeletal Muscle |
title_sort |
exercise training attenuates ovariectomy-induced alterations in skeletal muscle remodeling, apoptotic signaling, and atrophy signaling in rat skeletal muscle |
publisher |
Korean Continence Society |
publishDate |
2021 |
url |
https://doaj.org/article/8fced9389d924c49956d708c74ff0692 |
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