The contributions of interlocking loops and extensive nonlinearity to the properties of circadian clock models.

<h4>Background</h4>Sensitivity and robustness are essential properties of circadian clock systems, enabling them to respond to the environment but resist noisy variations. These properties should be recapitulated in computational models of the circadian clock. Highly nonlinear kinetics a...

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Autores principales:	Treenut Saithong, Kevin J Painter, Andrew J Millar
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8fcef2ebf1fa46cc9ef01315fd789464
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id	oai:doaj.org-article:8fcef2ebf1fa46cc9ef01315fd789464
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spelling	oai:doaj.org-article:8fcef2ebf1fa46cc9ef01315fd7894642021-11-18T07:02:15ZThe contributions of interlocking loops and extensive nonlinearity to the properties of circadian clock models.1932-620310.1371/journal.pone.0013867https://doaj.org/article/8fcef2ebf1fa46cc9ef01315fd7894642010-11-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21152419/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Sensitivity and robustness are essential properties of circadian clock systems, enabling them to respond to the environment but resist noisy variations. These properties should be recapitulated in computational models of the circadian clock. Highly nonlinear kinetics and multiple loops are often incorporated into models to match experimental time-series data, but these also impact on model properties for clock models.<h4>Methodology/principal findings</h4>Here, we study the consequences of complicated structure and nonlinearity using simple Goodwin-type oscillators and the complex Arabidopsis circadian clock models. Sensitivity analysis of the simple oscillators implies that an interlocked multi-loop structure reinforces sensitivity/robustness properties, enhancing the response to external and internal variations. Furthermore, we found that reducing the degree of nonlinearity could sometimes enhance the robustness of models, implying that ad hoc incorporation of nonlinearity could be detrimental to a model's perceived credibility.<h4>Conclusion</h4>The correct multi-loop structure and degree of nonlinearity are therefore critical in contributing to the desired properties of a model as well as its capacity to match experimental data.Treenut SaithongKevin J PainterAndrew J MillarPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 11, p e13867 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Treenut Saithong Kevin J Painter Andrew J Millar The contributions of interlocking loops and extensive nonlinearity to the properties of circadian clock models.
description	<h4>Background</h4>Sensitivity and robustness are essential properties of circadian clock systems, enabling them to respond to the environment but resist noisy variations. These properties should be recapitulated in computational models of the circadian clock. Highly nonlinear kinetics and multiple loops are often incorporated into models to match experimental time-series data, but these also impact on model properties for clock models.<h4>Methodology/principal findings</h4>Here, we study the consequences of complicated structure and nonlinearity using simple Goodwin-type oscillators and the complex Arabidopsis circadian clock models. Sensitivity analysis of the simple oscillators implies that an interlocked multi-loop structure reinforces sensitivity/robustness properties, enhancing the response to external and internal variations. Furthermore, we found that reducing the degree of nonlinearity could sometimes enhance the robustness of models, implying that ad hoc incorporation of nonlinearity could be detrimental to a model's perceived credibility.<h4>Conclusion</h4>The correct multi-loop structure and degree of nonlinearity are therefore critical in contributing to the desired properties of a model as well as its capacity to match experimental data.
format	article
author	Treenut Saithong Kevin J Painter Andrew J Millar
author_facet	Treenut Saithong Kevin J Painter Andrew J Millar
author_sort	Treenut Saithong
title	The contributions of interlocking loops and extensive nonlinearity to the properties of circadian clock models.
title_short	The contributions of interlocking loops and extensive nonlinearity to the properties of circadian clock models.
title_full	The contributions of interlocking loops and extensive nonlinearity to the properties of circadian clock models.
title_fullStr	The contributions of interlocking loops and extensive nonlinearity to the properties of circadian clock models.
title_full_unstemmed	The contributions of interlocking loops and extensive nonlinearity to the properties of circadian clock models.
title_sort	contributions of interlocking loops and extensive nonlinearity to the properties of circadian clock models.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/8fcef2ebf1fa46cc9ef01315fd789464
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The contributions of interlocking loops and extensive nonlinearity to the properties of circadian clock models.

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