Abscopal Effects in Metastatic Cancer: Is a Predictive Approach Possible to Improve Individual Outcomes?

Patients with metastatic cancers often require radiotherapy (RT) as a palliative therapy for cancer pain. RT can, however, also induce systemic antitumor effects outside of the irradiated field (abscopal effects) in various cancer entities. The occurrence of the abscopal effect is associated with a...

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Autores principales:	Barbara Link, Adriana Torres Crigna, Michael Hölzel, Frank A. Giordano, Olga Golubnitschaja
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	predictive preventive personalized medicine (3PM) molecular patterns abscopal effects cancers metastatic disease radiotherapy Medicine R
Acceso en línea:	https://doaj.org/article/8fd027c4b1ac497fae902d5b0aef94e4
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id	oai:doaj.org-article:8fd027c4b1ac497fae902d5b0aef94e4
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spelling	oai:doaj.org-article:8fd027c4b1ac497fae902d5b0aef94e42021-11-11T17:44:40ZAbscopal Effects in Metastatic Cancer: Is a Predictive Approach Possible to Improve Individual Outcomes?10.3390/jcm102151242077-0383https://doaj.org/article/8fd027c4b1ac497fae902d5b0aef94e42021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/5124https://doaj.org/toc/2077-0383Patients with metastatic cancers often require radiotherapy (RT) as a palliative therapy for cancer pain. RT can, however, also induce systemic antitumor effects outside of the irradiated field (abscopal effects) in various cancer entities. The occurrence of the abscopal effect is associated with a specific immunological activation in response to RT-induced cell death, which is mainly seen under concomitant immune checkpoint blockade. Even if the number of reported apscopal effects has increased since the introduction of immune checkpoint inhibition, its occurrence is still considered rare and unpredictable. The cases reported so far may nevertheless allow for identifying first biomarkers and clinical patterns. We here review biomarkers that may be helpful to predict the occurrence of abscopal effects and hence to optimize therapy for patients with metastatic cancers.Barbara LinkAdriana Torres CrignaMichael HölzelFrank A. GiordanoOlga GolubnitschajaMDPI AGarticlepredictive preventive personalized medicine (3PM)molecular patternsabscopal effectscancersmetastatic diseaseradiotherapyMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5124, p 5124 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	predictive preventive personalized medicine (3PM) molecular patterns abscopal effects cancers metastatic disease radiotherapy Medicine R
spellingShingle	predictive preventive personalized medicine (3PM) molecular patterns abscopal effects cancers metastatic disease radiotherapy Medicine R Barbara Link Adriana Torres Crigna Michael Hölzel Frank A. Giordano Olga Golubnitschaja Abscopal Effects in Metastatic Cancer: Is a Predictive Approach Possible to Improve Individual Outcomes?
description	Patients with metastatic cancers often require radiotherapy (RT) as a palliative therapy for cancer pain. RT can, however, also induce systemic antitumor effects outside of the irradiated field (abscopal effects) in various cancer entities. The occurrence of the abscopal effect is associated with a specific immunological activation in response to RT-induced cell death, which is mainly seen under concomitant immune checkpoint blockade. Even if the number of reported apscopal effects has increased since the introduction of immune checkpoint inhibition, its occurrence is still considered rare and unpredictable. The cases reported so far may nevertheless allow for identifying first biomarkers and clinical patterns. We here review biomarkers that may be helpful to predict the occurrence of abscopal effects and hence to optimize therapy for patients with metastatic cancers.
format	article
author	Barbara Link Adriana Torres Crigna Michael Hölzel Frank A. Giordano Olga Golubnitschaja
author_facet	Barbara Link Adriana Torres Crigna Michael Hölzel Frank A. Giordano Olga Golubnitschaja
author_sort	Barbara Link
title	Abscopal Effects in Metastatic Cancer: Is a Predictive Approach Possible to Improve Individual Outcomes?
title_short	Abscopal Effects in Metastatic Cancer: Is a Predictive Approach Possible to Improve Individual Outcomes?
title_full	Abscopal Effects in Metastatic Cancer: Is a Predictive Approach Possible to Improve Individual Outcomes?
title_fullStr	Abscopal Effects in Metastatic Cancer: Is a Predictive Approach Possible to Improve Individual Outcomes?
title_full_unstemmed	Abscopal Effects in Metastatic Cancer: Is a Predictive Approach Possible to Improve Individual Outcomes?
title_sort	abscopal effects in metastatic cancer: is a predictive approach possible to improve individual outcomes?
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/8fd027c4b1ac497fae902d5b0aef94e4
work_keys_str_mv	AT barbaralink abscopaleffectsinmetastaticcancerisapredictiveapproachpossibletoimproveindividualoutcomes AT adrianatorrescrigna abscopaleffectsinmetastaticcancerisapredictiveapproachpossibletoimproveindividualoutcomes AT michaelholzel abscopaleffectsinmetastaticcancerisapredictiveapproachpossibletoimproveindividualoutcomes AT frankagiordano abscopaleffectsinmetastaticcancerisapredictiveapproachpossibletoimproveindividualoutcomes AT olgagolubnitschaja abscopaleffectsinmetastaticcancerisapredictiveapproachpossibletoimproveindividualoutcomes
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Abscopal Effects in Metastatic Cancer: Is a Predictive Approach Possible to Improve Individual Outcomes?

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