Characteristics and therapeutic potential of sodium-dependent phosphate cotransporters in relation to idiopathic basal ganglia calcification

Type-III sodium-dependent phosphate transporters 1 and 2 (PiT 1 and PiT 2, respectively) are proteins encoded by SLC20A1 and SLC20A2, respectively. The ubiquitous distribution of SLC20A1 and SLC20A2 mRNAs in mammalian tissues supports the housekeeping maintenance and homeostasis of intracellular ino...

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Autores principales:	Masatoshi Inden, Hisaka Kurita, Isao Hozumi
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Idiopathic basal ganglia calcification (IBGC) Sodium-dependent phosphate cotransporter PiT1 PiT2 Inorganic phosphate (Pi) Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/8fd1865223504c0eb8f9c45f91c2edc5
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id	oai:doaj.org-article:8fd1865223504c0eb8f9c45f91c2edc5
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spelling	oai:doaj.org-article:8fd1865223504c0eb8f9c45f91c2edc52021-11-24T04:27:26ZCharacteristics and therapeutic potential of sodium-dependent phosphate cotransporters in relation to idiopathic basal ganglia calcification1347-861310.1016/j.jphs.2021.11.004https://doaj.org/article/8fd1865223504c0eb8f9c45f91c2edc52022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1347861321001110https://doaj.org/toc/1347-8613Type-III sodium-dependent phosphate transporters 1 and 2 (PiT 1 and PiT 2, respectively) are proteins encoded by SLC20A1 and SLC20A2, respectively. The ubiquitous distribution of SLC20A1 and SLC20A2 mRNAs in mammalian tissues supports the housekeeping maintenance and homeostasis of intracellular inorganic phosphate (Pi), which is absorbed from interstitial fluid for normal cellular functions. SLC20A2 variants have been found in patients with idiopathic basal ganglia calcification (IBGC), also known as Fahr's disease or primary familial brain calcification (PFBC). Thus, disrupted Pi homeostasis is considered one of the major factors in the pathogenic mechanism of IBGC. In this paper, among the causative genes of IBGC, we focused specifically on PiT2, and its potential for a therapeutic target of IBGC.Masatoshi IndenHisaka KuritaIsao HozumiElsevierarticleIdiopathic basal ganglia calcification (IBGC)Sodium-dependent phosphate cotransporterPiT1PiT2Inorganic phosphate (Pi)Therapeutics. PharmacologyRM1-950ENJournal of Pharmacological Sciences, Vol 148, Iss 1, Pp 152-155 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Idiopathic basal ganglia calcification (IBGC) Sodium-dependent phosphate cotransporter PiT1 PiT2 Inorganic phosphate (Pi) Therapeutics. Pharmacology RM1-950
spellingShingle	Idiopathic basal ganglia calcification (IBGC) Sodium-dependent phosphate cotransporter PiT1 PiT2 Inorganic phosphate (Pi) Therapeutics. Pharmacology RM1-950 Masatoshi Inden Hisaka Kurita Isao Hozumi Characteristics and therapeutic potential of sodium-dependent phosphate cotransporters in relation to idiopathic basal ganglia calcification
description	Type-III sodium-dependent phosphate transporters 1 and 2 (PiT 1 and PiT 2, respectively) are proteins encoded by SLC20A1 and SLC20A2, respectively. The ubiquitous distribution of SLC20A1 and SLC20A2 mRNAs in mammalian tissues supports the housekeeping maintenance and homeostasis of intracellular inorganic phosphate (Pi), which is absorbed from interstitial fluid for normal cellular functions. SLC20A2 variants have been found in patients with idiopathic basal ganglia calcification (IBGC), also known as Fahr's disease or primary familial brain calcification (PFBC). Thus, disrupted Pi homeostasis is considered one of the major factors in the pathogenic mechanism of IBGC. In this paper, among the causative genes of IBGC, we focused specifically on PiT2, and its potential for a therapeutic target of IBGC.
format	article
author	Masatoshi Inden Hisaka Kurita Isao Hozumi
author_facet	Masatoshi Inden Hisaka Kurita Isao Hozumi
author_sort	Masatoshi Inden
title	Characteristics and therapeutic potential of sodium-dependent phosphate cotransporters in relation to idiopathic basal ganglia calcification
title_short	Characteristics and therapeutic potential of sodium-dependent phosphate cotransporters in relation to idiopathic basal ganglia calcification
title_full	Characteristics and therapeutic potential of sodium-dependent phosphate cotransporters in relation to idiopathic basal ganglia calcification
title_fullStr	Characteristics and therapeutic potential of sodium-dependent phosphate cotransporters in relation to idiopathic basal ganglia calcification
title_full_unstemmed	Characteristics and therapeutic potential of sodium-dependent phosphate cotransporters in relation to idiopathic basal ganglia calcification
title_sort	characteristics and therapeutic potential of sodium-dependent phosphate cotransporters in relation to idiopathic basal ganglia calcification
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/8fd1865223504c0eb8f9c45f91c2edc5
work_keys_str_mv	AT masatoshiinden characteristicsandtherapeuticpotentialofsodiumdependentphosphatecotransportersinrelationtoidiopathicbasalgangliacalcification AT hisakakurita characteristicsandtherapeuticpotentialofsodiumdependentphosphatecotransportersinrelationtoidiopathicbasalgangliacalcification AT isaohozumi characteristicsandtherapeuticpotentialofsodiumdependentphosphatecotransportersinrelationtoidiopathicbasalgangliacalcification
_version_	1718415991467147264

Characteristics and therapeutic potential of sodium-dependent phosphate cotransporters in relation to idiopathic basal ganglia calcification

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