The Emergence of Bacterial “Hopeful Monsters”

ABSTRACT The global spread of antibiotic-resistant bacteria has largely been driven by the dissemination of successful lineages. A particularly important example is sequence type (ST) 258 of Klebsiella pneumoniae, a common cause of health care-associated infections. Representatives of this lineage c...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Nicholas J. Croucher, Keith P. Klugman
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2014
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/8fd208e356e34e7eb32ab9398ccbfa06
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8fd208e356e34e7eb32ab9398ccbfa06
record_format	dspace
spelling	oai:doaj.org-article:8fd208e356e34e7eb32ab9398ccbfa062021-11-15T15:47:22ZThe Emergence of Bacterial “Hopeful Monsters”10.1128/mBio.01550-142150-7511https://doaj.org/article/8fd208e356e34e7eb32ab9398ccbfa062014-08-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01550-14https://doaj.org/toc/2150-7511ABSTRACT The global spread of antibiotic-resistant bacteria has largely been driven by the dissemination of successful lineages. A particularly important example is sequence type (ST) 258 of Klebsiella pneumoniae, a common cause of health care-associated infections. Representatives of this lineage carry a variable array of plasmid-borne resistance genes, typically including a carbapenemase effective against the full range of clinically important β-lactams. In their recent mBio article, Chen et al. [mBio 5(3):e01355-14] described how ST258 emerged through “hybridization” between two other strains, with a second recombination resulting in the diversification of a key antigen. This commentary describes the findings in the context of other examples where saltational evolution has resulted in the sudden emergence of important pathogenic bacteria.Nicholas J. CroucherKeith P. KlugmanAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 5, Iss 4 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Nicholas J. Croucher Keith P. Klugman The Emergence of Bacterial “Hopeful Monsters”
description	ABSTRACT The global spread of antibiotic-resistant bacteria has largely been driven by the dissemination of successful lineages. A particularly important example is sequence type (ST) 258 of Klebsiella pneumoniae, a common cause of health care-associated infections. Representatives of this lineage carry a variable array of plasmid-borne resistance genes, typically including a carbapenemase effective against the full range of clinically important β-lactams. In their recent mBio article, Chen et al. [mBio 5(3):e01355-14] described how ST258 emerged through “hybridization” between two other strains, with a second recombination resulting in the diversification of a key antigen. This commentary describes the findings in the context of other examples where saltational evolution has resulted in the sudden emergence of important pathogenic bacteria.
format	article
author	Nicholas J. Croucher Keith P. Klugman
author_facet	Nicholas J. Croucher Keith P. Klugman
author_sort	Nicholas J. Croucher
title	The Emergence of Bacterial “Hopeful Monsters”
title_short	The Emergence of Bacterial “Hopeful Monsters”
title_full	The Emergence of Bacterial “Hopeful Monsters”
title_fullStr	The Emergence of Bacterial “Hopeful Monsters”
title_full_unstemmed	The Emergence of Bacterial “Hopeful Monsters”
title_sort	emergence of bacterial “hopeful monsters”
publisher	American Society for Microbiology
publishDate	2014
url	https://doaj.org/article/8fd208e356e34e7eb32ab9398ccbfa06
work_keys_str_mv	AT nicholasjcroucher theemergenceofbacterialhopefulmonsters AT keithpklugman theemergenceofbacterialhopefulmonsters AT nicholasjcroucher emergenceofbacterialhopefulmonsters AT keithpklugman emergenceofbacterialhopefulmonsters
_version_	1718427531404640256

The Emergence of Bacterial “Hopeful Monsters”

Ejemplares similares