Glycan-dependent cell adhesion mechanism of Tc toxins

Although Tc toxins are a major class of bacterial toxin translocation systems, little is known about their receptor binding. Here, the authors identify heparins/heparan sulfates and Lewis antigens as receptors for different Tc toxins, determine cryo-EM structures of three toxin-glycan complexes and...

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Autores principales:	Daniel Roderer, Felix Bröcker, Oleg Sitsel, Paulina Kaplonek, Franziska Leidreiter, Peter H. Seeberger, Stefan Raunser
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8fd46558833e4d1b98f8b3ad1804b7b8
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spelling	oai:doaj.org-article:8fd46558833e4d1b98f8b3ad1804b7b82021-12-02T17:51:19ZGlycan-dependent cell adhesion mechanism of Tc toxins10.1038/s41467-020-16536-72041-1723https://doaj.org/article/8fd46558833e4d1b98f8b3ad1804b7b82020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16536-7https://doaj.org/toc/2041-1723Although Tc toxins are a major class of bacterial toxin translocation systems, little is known about their receptor binding. Here, the authors identify heparins/heparan sulfates and Lewis antigens as receptors for different Tc toxins, determine cryo-EM structures of three toxin-glycan complexes and propose a two-step cell adhesion mechanism for Tc toxins.Daniel RodererFelix BröckerOleg SitselPaulina KaplonekFranziska LeidreiterPeter H. SeebergerStefan RaunserNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Daniel Roderer Felix Bröcker Oleg Sitsel Paulina Kaplonek Franziska Leidreiter Peter H. Seeberger Stefan Raunser Glycan-dependent cell adhesion mechanism of Tc toxins
description	Although Tc toxins are a major class of bacterial toxin translocation systems, little is known about their receptor binding. Here, the authors identify heparins/heparan sulfates and Lewis antigens as receptors for different Tc toxins, determine cryo-EM structures of three toxin-glycan complexes and propose a two-step cell adhesion mechanism for Tc toxins.
format	article
author	Daniel Roderer Felix Bröcker Oleg Sitsel Paulina Kaplonek Franziska Leidreiter Peter H. Seeberger Stefan Raunser
author_facet	Daniel Roderer Felix Bröcker Oleg Sitsel Paulina Kaplonek Franziska Leidreiter Peter H. Seeberger Stefan Raunser
author_sort	Daniel Roderer
title	Glycan-dependent cell adhesion mechanism of Tc toxins
title_short	Glycan-dependent cell adhesion mechanism of Tc toxins
title_full	Glycan-dependent cell adhesion mechanism of Tc toxins
title_fullStr	Glycan-dependent cell adhesion mechanism of Tc toxins
title_full_unstemmed	Glycan-dependent cell adhesion mechanism of Tc toxins
title_sort	glycan-dependent cell adhesion mechanism of tc toxins
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/8fd46558833e4d1b98f8b3ad1804b7b8
work_keys_str_mv	AT danielroderer glycandependentcelladhesionmechanismoftctoxins AT felixbrocker glycandependentcelladhesionmechanismoftctoxins AT olegsitsel glycandependentcelladhesionmechanismoftctoxins AT paulinakaplonek glycandependentcelladhesionmechanismoftctoxins AT franziskaleidreiter glycandependentcelladhesionmechanismoftctoxins AT peterhseeberger glycandependentcelladhesionmechanismoftctoxins AT stefanraunser glycandependentcelladhesionmechanismoftctoxins
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Glycan-dependent cell adhesion mechanism of Tc toxins

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