Human coronaviruses associated with upper respiratory tract infections in three rural areas of Ghana.

<h4>Background</h4>Acute respiratory tract infections (ARI) are the leading cause of morbidity and mortality in developing countries, especially in Africa. This study sought to determine whether human coronaviruses (HCoVs) are associated with upper respiratory tract infections among olde...

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Autores principales:	Michael Owusu, Augustina Annan, Victor Max Corman, Richard Larbi, Priscilla Anti, Jan Felix Drexler, Olivia Agbenyega, Yaw Adu-Sarkodie, Christian Drosten
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8fd8828737b04f9fa2163418c71fcb3f
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spelling	oai:doaj.org-article:8fd8828737b04f9fa2163418c71fcb3f2021-11-25T06:06:28ZHuman coronaviruses associated with upper respiratory tract infections in three rural areas of Ghana.1932-620310.1371/journal.pone.0099782https://doaj.org/article/8fd8828737b04f9fa2163418c71fcb3f2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25080241/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Acute respiratory tract infections (ARI) are the leading cause of morbidity and mortality in developing countries, especially in Africa. This study sought to determine whether human coronaviruses (HCoVs) are associated with upper respiratory tract infections among older children and adults in Ghana.<h4>Methods</h4>We conducted a case control study among older children and adults in three rural areas of Ghana using asymptomatic subjects as controls. Nasal/Nasopharyngeal swabs were tested for Middle East respiratory syndrome coronavirus (MERS-CoV), HCoV-22E, HCoV-OC43, HCoV-NL63 and HCoV-HKU1 using Reverse Transcriptase Real-Time Polymerase Chain Reaction.<h4>Results</h4>Out of 1,213 subjects recruited, 150 (12.4%) were positive for one or more viruses. Of these, single virus detections occurred in 146 subjects (12.0%) and multiple detections occurred in 4 (0.3%). Compared with control subjects, infections with HCoV-229E (OR = 5.15, 95%CI = 2.24-11.78), HCoV-OC43 (OR = 6.16, 95%CI = 1.77-21.65) and combine HCoVs (OR = 2.36, 95%CI = 1.5 = 3.72) were associated with upper respiratory tract infections. HCoVs were found to be seasonally dependent with significant detections in the harmattan season (mainly HCoV-229E) and wet season (mainly HCoV-NL63). A comparison of the obtained sequences resulted in no differences to sequences already published in GenBank.<h4>Conclusion</h4>HCoVs could play significant role in causing upper respiratory tract infections among adults and older children in rural areas of Ghana.Michael OwusuAugustina AnnanVictor Max CormanRichard LarbiPriscilla AntiJan Felix DrexlerOlivia AgbenyegaYaw Adu-SarkodieChristian DrostenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 7, p e99782 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Michael Owusu Augustina Annan Victor Max Corman Richard Larbi Priscilla Anti Jan Felix Drexler Olivia Agbenyega Yaw Adu-Sarkodie Christian Drosten Human coronaviruses associated with upper respiratory tract infections in three rural areas of Ghana.
description	<h4>Background</h4>Acute respiratory tract infections (ARI) are the leading cause of morbidity and mortality in developing countries, especially in Africa. This study sought to determine whether human coronaviruses (HCoVs) are associated with upper respiratory tract infections among older children and adults in Ghana.<h4>Methods</h4>We conducted a case control study among older children and adults in three rural areas of Ghana using asymptomatic subjects as controls. Nasal/Nasopharyngeal swabs were tested for Middle East respiratory syndrome coronavirus (MERS-CoV), HCoV-22E, HCoV-OC43, HCoV-NL63 and HCoV-HKU1 using Reverse Transcriptase Real-Time Polymerase Chain Reaction.<h4>Results</h4>Out of 1,213 subjects recruited, 150 (12.4%) were positive for one or more viruses. Of these, single virus detections occurred in 146 subjects (12.0%) and multiple detections occurred in 4 (0.3%). Compared with control subjects, infections with HCoV-229E (OR = 5.15, 95%CI = 2.24-11.78), HCoV-OC43 (OR = 6.16, 95%CI = 1.77-21.65) and combine HCoVs (OR = 2.36, 95%CI = 1.5 = 3.72) were associated with upper respiratory tract infections. HCoVs were found to be seasonally dependent with significant detections in the harmattan season (mainly HCoV-229E) and wet season (mainly HCoV-NL63). A comparison of the obtained sequences resulted in no differences to sequences already published in GenBank.<h4>Conclusion</h4>HCoVs could play significant role in causing upper respiratory tract infections among adults and older children in rural areas of Ghana.
format	article
author	Michael Owusu Augustina Annan Victor Max Corman Richard Larbi Priscilla Anti Jan Felix Drexler Olivia Agbenyega Yaw Adu-Sarkodie Christian Drosten
author_facet	Michael Owusu Augustina Annan Victor Max Corman Richard Larbi Priscilla Anti Jan Felix Drexler Olivia Agbenyega Yaw Adu-Sarkodie Christian Drosten
author_sort	Michael Owusu
title	Human coronaviruses associated with upper respiratory tract infections in three rural areas of Ghana.
title_short	Human coronaviruses associated with upper respiratory tract infections in three rural areas of Ghana.
title_full	Human coronaviruses associated with upper respiratory tract infections in three rural areas of Ghana.
title_fullStr	Human coronaviruses associated with upper respiratory tract infections in three rural areas of Ghana.
title_full_unstemmed	Human coronaviruses associated with upper respiratory tract infections in three rural areas of Ghana.
title_sort	human coronaviruses associated with upper respiratory tract infections in three rural areas of ghana.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/8fd8828737b04f9fa2163418c71fcb3f
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Human coronaviruses associated with upper respiratory tract infections in three rural areas of Ghana.

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