Vaccination as a Strategy to Prevent Bluetongue Virus Vertical Transmission

Bluetongue virus (BTV) produces an economically important disease in ruminants of compulsory notification to the OIE. BTV is typically transmitted by the bite of <i>Culicoides</i> spp., however, some BTV strains can be transmitted vertically, and this is associated with fetus malformatio...

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Autores principales:	José M. Rojas, Verónica Martín, Noemí Sevilla
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	orbivirus bluetongue vaccination vertical transmission review Medicine R
Acceso en línea:	https://doaj.org/article/8fd9a578af704b1bbe806bcc53ab99d1
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spelling	oai:doaj.org-article:8fd9a578af704b1bbe806bcc53ab99d12021-11-25T18:38:57ZVaccination as a Strategy to Prevent Bluetongue Virus Vertical Transmission10.3390/pathogens101115282076-0817https://doaj.org/article/8fd9a578af704b1bbe806bcc53ab99d12021-11-01T00:00:00Zhttps://www.mdpi.com/2076-0817/10/11/1528https://doaj.org/toc/2076-0817Bluetongue virus (BTV) produces an economically important disease in ruminants of compulsory notification to the OIE. BTV is typically transmitted by the bite of <i>Culicoides</i> spp., however, some BTV strains can be transmitted vertically, and this is associated with fetus malformations and abortions. The viral factors associated with the virus potency to cross the placental barrier are not well defined. The potency of vertical transmission is retained and sometimes even increased in live attenuated BTV vaccine strains. Because BTV possesses a segmented genome, the possibility of reassortment of vaccination strains with wild-type virus could even favor the transmission of this phenotype. In the present review, we will describe the non-vector-based BTV infection routes and discuss the experimental vaccination strategies that offer advantages over this drawback of some live attenuated BTV vaccines.José M. RojasVerónica MartínNoemí SevillaMDPI AGarticleorbivirusbluetonguevaccinationvertical transmissionreviewMedicineRENPathogens, Vol 10, Iss 1528, p 1528 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	orbivirus bluetongue vaccination vertical transmission review Medicine R
spellingShingle	orbivirus bluetongue vaccination vertical transmission review Medicine R José M. Rojas Verónica Martín Noemí Sevilla Vaccination as a Strategy to Prevent Bluetongue Virus Vertical Transmission
description	Bluetongue virus (BTV) produces an economically important disease in ruminants of compulsory notification to the OIE. BTV is typically transmitted by the bite of <i>Culicoides</i> spp., however, some BTV strains can be transmitted vertically, and this is associated with fetus malformations and abortions. The viral factors associated with the virus potency to cross the placental barrier are not well defined. The potency of vertical transmission is retained and sometimes even increased in live attenuated BTV vaccine strains. Because BTV possesses a segmented genome, the possibility of reassortment of vaccination strains with wild-type virus could even favor the transmission of this phenotype. In the present review, we will describe the non-vector-based BTV infection routes and discuss the experimental vaccination strategies that offer advantages over this drawback of some live attenuated BTV vaccines.
format	article
author	José M. Rojas Verónica Martín Noemí Sevilla
author_facet	José M. Rojas Verónica Martín Noemí Sevilla
author_sort	José M. Rojas
title	Vaccination as a Strategy to Prevent Bluetongue Virus Vertical Transmission
title_short	Vaccination as a Strategy to Prevent Bluetongue Virus Vertical Transmission
title_full	Vaccination as a Strategy to Prevent Bluetongue Virus Vertical Transmission
title_fullStr	Vaccination as a Strategy to Prevent Bluetongue Virus Vertical Transmission
title_full_unstemmed	Vaccination as a Strategy to Prevent Bluetongue Virus Vertical Transmission
title_sort	vaccination as a strategy to prevent bluetongue virus vertical transmission
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/8fd9a578af704b1bbe806bcc53ab99d1
work_keys_str_mv	AT josemrojas vaccinationasastrategytopreventbluetonguevirusverticaltransmission AT veronicamartin vaccinationasastrategytopreventbluetonguevirusverticaltransmission AT noemisevilla vaccinationasastrategytopreventbluetonguevirusverticaltransmission
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Vaccination as a Strategy to Prevent Bluetongue Virus Vertical Transmission

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