Evaluation of CD3 and CD4 Positive Lymphocytes in Trichomonas Vaginalis Infection

BACKGROUND AND OBJECTIVE: Trichomonas Vaginalis is the most prevalent nonviral agent that causes sexually transmitted disease (STD) in human. This organism causes vaginitis, infertility, preterm labour, premature rupture of membrane and low birth weight. This study was carried out to study the cellu...

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Autores principales:	AR Abdollahi, F Mohammadzadeh
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2011
Materias:	cd4 positive lymphocyte cd3 positive lymphocyte interleukin-10 trichomona vaginalis Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/8fdb506e4c834ad7ac44489c7eb8fee5
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id	oai:doaj.org-article:8fdb506e4c834ad7ac44489c7eb8fee5
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spelling	oai:doaj.org-article:8fdb506e4c834ad7ac44489c7eb8fee52021-11-10T08:56:27ZEvaluation of CD3 and CD4 Positive Lymphocytes in Trichomonas Vaginalis Infection1561-41072251-7170https://doaj.org/article/8fdb506e4c834ad7ac44489c7eb8fee52011-03-01T00:00:00Zhttp://jbums.org/article-1-3743-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Trichomonas Vaginalis is the most prevalent nonviral agent that causes sexually transmitted disease (STD) in human. This organism causes vaginitis, infertility, preterm labour, premature rupture of membrane and low birth weight. This study was carried out to study the cellular immunity systems response to this infection through evaluation of CD3 and CD4 positive lymphocytes and cytokine interleukin 10 in the patients contaminated with this infection. METHODS: A cross-sectional study was conducted to compare 65 women having developed clinical symptoms of trichomonasis with control group in terms of age as well as social and economic conditions. They were compared in terms of the number of CD3 and CD4 lymphocytes and IL10 cytokine concentration in their blood.FINDINGS: Of 65 women studied, 25 (38.5%) were diagnosed with trichomonas vaginalis infection in the lab scale (vaginal discharge culture). More specifically, the percentage of T lymphocytes (CD3 positive cells) in infected women (79.75±0.7%) was (59.95±10%) higher than in the control group (p≤0.0001). Auxiliary T lymphocytes (CD4 positive cells) in the infected women (67.94±0.96%) were also meaningfully (32.52±0.93%) higher than in the control group (p≤0.0001). Moreover, a meaningful difference was observed in the IL10 serum level between the patient group (119 ±42% pg/ml) and the control group (1.02±0.14% pg/ml). (p≤0.001)CONCLUSION: Based on the results of this study, cellular immunity plays a significant role in controlling trichomonas vaginalis infections. Therefore, another study with more samples and multi centers for confirmation are strongly recommended.AR AbdollahiF MohammadzadehBabol University of Medical Sciencesarticlecd4 positive lymphocytecd3 positive lymphocyteinterleukin-10trichomona vaginalisMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 13, Iss 2, Pp 63-67 (2011)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	cd4 positive lymphocyte cd3 positive lymphocyte interleukin-10 trichomona vaginalis Medicine R Medicine (General) R5-920
spellingShingle	cd4 positive lymphocyte cd3 positive lymphocyte interleukin-10 trichomona vaginalis Medicine R Medicine (General) R5-920 AR Abdollahi F Mohammadzadeh Evaluation of CD3 and CD4 Positive Lymphocytes in Trichomonas Vaginalis Infection
description	BACKGROUND AND OBJECTIVE: Trichomonas Vaginalis is the most prevalent nonviral agent that causes sexually transmitted disease (STD) in human. This organism causes vaginitis, infertility, preterm labour, premature rupture of membrane and low birth weight. This study was carried out to study the cellular immunity systems response to this infection through evaluation of CD3 and CD4 positive lymphocytes and cytokine interleukin 10 in the patients contaminated with this infection. METHODS: A cross-sectional study was conducted to compare 65 women having developed clinical symptoms of trichomonasis with control group in terms of age as well as social and economic conditions. They were compared in terms of the number of CD3 and CD4 lymphocytes and IL10 cytokine concentration in their blood.FINDINGS: Of 65 women studied, 25 (38.5%) were diagnosed with trichomonas vaginalis infection in the lab scale (vaginal discharge culture). More specifically, the percentage of T lymphocytes (CD3 positive cells) in infected women (79.75±0.7%) was (59.95±10%) higher than in the control group (p≤0.0001). Auxiliary T lymphocytes (CD4 positive cells) in the infected women (67.94±0.96%) were also meaningfully (32.52±0.93%) higher than in the control group (p≤0.0001). Moreover, a meaningful difference was observed in the IL10 serum level between the patient group (119 ±42% pg/ml) and the control group (1.02±0.14% pg/ml). (p≤0.001)CONCLUSION: Based on the results of this study, cellular immunity plays a significant role in controlling trichomonas vaginalis infections. Therefore, another study with more samples and multi centers for confirmation are strongly recommended.
format	article
author	AR Abdollahi F Mohammadzadeh
author_facet	AR Abdollahi F Mohammadzadeh
author_sort	AR Abdollahi
title	Evaluation of CD3 and CD4 Positive Lymphocytes in Trichomonas Vaginalis Infection
title_short	Evaluation of CD3 and CD4 Positive Lymphocytes in Trichomonas Vaginalis Infection
title_full	Evaluation of CD3 and CD4 Positive Lymphocytes in Trichomonas Vaginalis Infection
title_fullStr	Evaluation of CD3 and CD4 Positive Lymphocytes in Trichomonas Vaginalis Infection
title_full_unstemmed	Evaluation of CD3 and CD4 Positive Lymphocytes in Trichomonas Vaginalis Infection
title_sort	evaluation of cd3 and cd4 positive lymphocytes in trichomonas vaginalis infection
publisher	Babol University of Medical Sciences
publishDate	2011
url	https://doaj.org/article/8fdb506e4c834ad7ac44489c7eb8fee5
work_keys_str_mv	AT arabdollahi evaluationofcd3andcd4positivelymphocytesintrichomonasvaginalisinfection AT fmohammadzadeh evaluationofcd3andcd4positivelymphocytesintrichomonasvaginalisinfection
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Evaluation of CD3 and CD4 Positive Lymphocytes in Trichomonas Vaginalis Infection

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