The Correlation of Type 2 Diabetes Status with Bone Mineral Density in Middle-Aged Adults

Xiaocong Yao,1 Xiaocheng Xu,2 Fang Jin,1 Zhongxin Zhu1,3 1Department of Osteoporosis Care and Control, The First People’s Hospital of Xiaoshan District, Hangzhou, Zhejiang 311200, People’s Republic of China; 2Department of Cancer Medicine, The First People’s Hospital of...

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Autores principales:	Yao X, Xu X, Jin F, Zhu Z
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	diabetes glucose hba1c bone health nhanes Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/8fdc918d63b742d5b939fdc97bad8804
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spelling	oai:doaj.org-article:8fdc918d63b742d5b939fdc97bad88042021-12-02T11:05:57ZThe Correlation of Type 2 Diabetes Status with Bone Mineral Density in Middle-Aged Adults1178-7007https://doaj.org/article/8fdc918d63b742d5b939fdc97bad88042020-09-01T00:00:00Zhttps://www.dovepress.com/the-correlation-of-type-2-diabetes-status-with-bone-mineral-density-in-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Xiaocong Yao,1 Xiaocheng Xu,2 Fang Jin,1 Zhongxin Zhu1,3 1Department of Osteoporosis Care and Control, The First People’s Hospital of Xiaoshan District, Hangzhou, Zhejiang 311200, People’s Republic of China; 2Department of Cancer Medicine, The First People’s Hospital of Xiaoshan District, Hangzhou, Zhejiang 311200, People’s Republic of China; 3Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, People’s Republic of ChinaCorrespondence: Zhongxin Zhu Email orthozzx@163.comBackground: Bone metabolism can be influenced by type 2 diabetes mellitus (T2DM). However, the relationship between T2DM and bone mineral density (BMD) remains inconsistent. This study explored the differences in BMD in middle-aged adults with and without T2DM.Methods: We conducted a cross-sectional study of 4986 participants aged 40– 59 years who participated in the National Health and Nutrition Examination Survey (NHANES) 2011– 2018. We performed multivariable logistic regression models to evaluate the associations between T2DM status, serum glucose, glycohemoglobin (HbA1c), disease duration and lumbar BMD.Results: There was a positive association between T2DM status and lumbar BMD in all three models (model 1: β=0.039, 95% CI: 0.025– 0.052; model 2: β=0.045, 95% CI: 0.031– 0.059; model 3: β=0.035, 95% CI: 0.014– 0.055). In the subgroup analysis stratified by gender, this positive association existed in both gender after adjusting for confounders (males: β=0.033, 95% CI: 0.003– 0.062; females: β=0.035, 95% CI: 0.008– 0.062). Besides, there were no significant associations of serum glucose, HbA1c, disease duration with lumbar BMD in both genders with T2DM.Conclusion: This study indicated that middle-aged adults with T2DM had significantly higher lumbar BMD compared with those without DM.Keywords: diabetes, glucose, HbA1c, bone health, NHANESYao XXu XJin FZhu ZDove Medical Pressarticlediabetesglucosehba1cbone healthnhanesSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 3269-3276 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetes glucose hba1c bone health nhanes Specialties of internal medicine RC581-951
spellingShingle	diabetes glucose hba1c bone health nhanes Specialties of internal medicine RC581-951 Yao X Xu X Jin F Zhu Z The Correlation of Type 2 Diabetes Status with Bone Mineral Density in Middle-Aged Adults
description	Xiaocong Yao,1 Xiaocheng Xu,2 Fang Jin,1 Zhongxin Zhu1,3 1Department of Osteoporosis Care and Control, The First People’s Hospital of Xiaoshan District, Hangzhou, Zhejiang 311200, People’s Republic of China; 2Department of Cancer Medicine, The First People’s Hospital of Xiaoshan District, Hangzhou, Zhejiang 311200, People’s Republic of China; 3Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, People’s Republic of ChinaCorrespondence: Zhongxin Zhu Email orthozzx@163.comBackground: Bone metabolism can be influenced by type 2 diabetes mellitus (T2DM). However, the relationship between T2DM and bone mineral density (BMD) remains inconsistent. This study explored the differences in BMD in middle-aged adults with and without T2DM.Methods: We conducted a cross-sectional study of 4986 participants aged 40– 59 years who participated in the National Health and Nutrition Examination Survey (NHANES) 2011– 2018. We performed multivariable logistic regression models to evaluate the associations between T2DM status, serum glucose, glycohemoglobin (HbA1c), disease duration and lumbar BMD.Results: There was a positive association between T2DM status and lumbar BMD in all three models (model 1: β=0.039, 95% CI: 0.025– 0.052; model 2: β=0.045, 95% CI: 0.031– 0.059; model 3: β=0.035, 95% CI: 0.014– 0.055). In the subgroup analysis stratified by gender, this positive association existed in both gender after adjusting for confounders (males: β=0.033, 95% CI: 0.003– 0.062; females: β=0.035, 95% CI: 0.008– 0.062). Besides, there were no significant associations of serum glucose, HbA1c, disease duration with lumbar BMD in both genders with T2DM.Conclusion: This study indicated that middle-aged adults with T2DM had significantly higher lumbar BMD compared with those without DM.Keywords: diabetes, glucose, HbA1c, bone health, NHANES
format	article
author	Yao X Xu X Jin F Zhu Z
author_facet	Yao X Xu X Jin F Zhu Z
author_sort	Yao X
title	The Correlation of Type 2 Diabetes Status with Bone Mineral Density in Middle-Aged Adults
title_short	The Correlation of Type 2 Diabetes Status with Bone Mineral Density in Middle-Aged Adults
title_full	The Correlation of Type 2 Diabetes Status with Bone Mineral Density in Middle-Aged Adults
title_fullStr	The Correlation of Type 2 Diabetes Status with Bone Mineral Density in Middle-Aged Adults
title_full_unstemmed	The Correlation of Type 2 Diabetes Status with Bone Mineral Density in Middle-Aged Adults
title_sort	correlation of type 2 diabetes status with bone mineral density in middle-aged adults
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/8fdc918d63b742d5b939fdc97bad8804
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The Correlation of Type 2 Diabetes Status with Bone Mineral Density in Middle-Aged Adults

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