Expression and Functional Roles of Eukaryotic Initiation Factor 4A Family Proteins in Human Cancers

The dysregulation of mRNA translation is common in malignancies and may lead to tumorigenesis and progression. Eukaryotic initiation factor 4A (eIF4A) proteins are essential for translation, exhibit bidirectional RNA helicase function, and act as RNA-dependent ATPases. In this review, we explored th...

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Autores principales:	Chen Xue, Xinyu Gu, Ganglei Li, Zhengyi Bao, Lanjuan Li
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	eIF4A family human cancer clinicopathological features biomarkers immune infiltrations Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/8fde19db312148df837f52deefe274fa
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spelling	oai:doaj.org-article:8fde19db312148df837f52deefe274fa2021-11-19T07:49:42ZExpression and Functional Roles of Eukaryotic Initiation Factor 4A Family Proteins in Human Cancers2296-634X10.3389/fcell.2021.711965https://doaj.org/article/8fde19db312148df837f52deefe274fa2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.711965/fullhttps://doaj.org/toc/2296-634XThe dysregulation of mRNA translation is common in malignancies and may lead to tumorigenesis and progression. Eukaryotic initiation factor 4A (eIF4A) proteins are essential for translation, exhibit bidirectional RNA helicase function, and act as RNA-dependent ATPases. In this review, we explored the predicted structures of the three eIF4A isoforms (eIF4A1, eIF4A2, and eIF4A3), and discussed possible explanations for which function during different translation stages (initiation, mRNA localization, export, and mRNA splicing). These proteins also frequently served as targets of microRNAs (miRNAs) or long noncoding RNAs (lncRNAs) to mediate epithelial-mesenchymal transition (EMT), which was associated with tumor cell invasion and metastasis. To define the differential expression of eIF4A family members, we applied the Tumor Immune Estimation Resource website. We figured out that the eIF4A family genes were differently expressed in specific cancer types. We also found that the level of the eIF4A family genes were associated with abundant immune cells infiltration and tumor purity. The associations between eIF4A proteins and cancer patient clinicopathological features suggested that eIF4A proteins might serve as biomarkers for early tumor diagnosis, histological classification, and clinical grading/staging, providing new tools for precise and individualized cancer treatment.Chen XueXinyu GuGanglei LiZhengyi BaoLanjuan LiFrontiers Media S.A.articleeIF4A familyhuman cancerclinicopathological featuresbiomarkersimmune infiltrationsBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	eIF4A family human cancer clinicopathological features biomarkers immune infiltrations Biology (General) QH301-705.5
spellingShingle	eIF4A family human cancer clinicopathological features biomarkers immune infiltrations Biology (General) QH301-705.5 Chen Xue Xinyu Gu Ganglei Li Zhengyi Bao Lanjuan Li Expression and Functional Roles of Eukaryotic Initiation Factor 4A Family Proteins in Human Cancers
description	The dysregulation of mRNA translation is common in malignancies and may lead to tumorigenesis and progression. Eukaryotic initiation factor 4A (eIF4A) proteins are essential for translation, exhibit bidirectional RNA helicase function, and act as RNA-dependent ATPases. In this review, we explored the predicted structures of the three eIF4A isoforms (eIF4A1, eIF4A2, and eIF4A3), and discussed possible explanations for which function during different translation stages (initiation, mRNA localization, export, and mRNA splicing). These proteins also frequently served as targets of microRNAs (miRNAs) or long noncoding RNAs (lncRNAs) to mediate epithelial-mesenchymal transition (EMT), which was associated with tumor cell invasion and metastasis. To define the differential expression of eIF4A family members, we applied the Tumor Immune Estimation Resource website. We figured out that the eIF4A family genes were differently expressed in specific cancer types. We also found that the level of the eIF4A family genes were associated with abundant immune cells infiltration and tumor purity. The associations between eIF4A proteins and cancer patient clinicopathological features suggested that eIF4A proteins might serve as biomarkers for early tumor diagnosis, histological classification, and clinical grading/staging, providing new tools for precise and individualized cancer treatment.
format	article
author	Chen Xue Xinyu Gu Ganglei Li Zhengyi Bao Lanjuan Li
author_facet	Chen Xue Xinyu Gu Ganglei Li Zhengyi Bao Lanjuan Li
author_sort	Chen Xue
title	Expression and Functional Roles of Eukaryotic Initiation Factor 4A Family Proteins in Human Cancers
title_short	Expression and Functional Roles of Eukaryotic Initiation Factor 4A Family Proteins in Human Cancers
title_full	Expression and Functional Roles of Eukaryotic Initiation Factor 4A Family Proteins in Human Cancers
title_fullStr	Expression and Functional Roles of Eukaryotic Initiation Factor 4A Family Proteins in Human Cancers
title_full_unstemmed	Expression and Functional Roles of Eukaryotic Initiation Factor 4A Family Proteins in Human Cancers
title_sort	expression and functional roles of eukaryotic initiation factor 4a family proteins in human cancers
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/8fde19db312148df837f52deefe274fa
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Expression and Functional Roles of Eukaryotic Initiation Factor 4A Family Proteins in Human Cancers

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