CD38 promotes pristane-induced chronic inflammation and increases susceptibility to experimental lupus by an apoptosis-driven and TRPM2-dependent mechanism

CD38 promotes pristane-induced chronic inflammation and increases susceptibility to experimental lupus by an apoptosis-driven and TRPM2-dependent mechanism

Abstract In this study, we investigated the role of CD38 in a pristane-induced murine model of lupus. CD38-deficient (Cd38 −/−) but not ART2-deficient (Art2 −/−) mice developed less severe lupus compared to wild type (WT) mice, and their protective phenotype consisted of (i) decreased IFN-I-stimulat...

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Main Authors: Sonia García-Rodríguez, Antonio Rosal-Vela, Davide Botta, Luz M. Cumba Garcia, Esther Zumaquero, Verónica Prados-Maniviesa, Daniela Cerezo-Wallis, Nicola Lo Buono, José-Ángel Robles-Guirado, Salvador Guerrero, Elena González-Paredes, Eduardo Andrés-León, Ángel Corbí, Matthias Mack, Friedrich Koch-Nolte, Ramón Merino, Mercedes Zubiaur, Frances E. Lund, Jaime Sancho
Format: article
Language:EN
Published: Nature Portfolio 2018
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/8fe211be315c44d088247d42cd122a41
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