Two-Dimensional Nanomaterials for Peripheral Nerve Engineering: Recent Advances and Potential Mechanisms

Peripheral nerve tissues possess the ability to regenerate within artificial nerve scaffolds, however, despite the advance of biomaterials that support nerve regeneration, the functional nerve recovery remains unsatisfactory. Importantly, the incorporation of two-dimensional nanomaterials has shown...

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Autores principales:	Zhiwen Yan, Cheng Chen, Gonzalo Rosso, Yun Qian, Cunyi Fan
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	two-dimensional nanomaterial peripheral nerve regeneration nerve scaffold nerve tissue engineering angiogenesis nanomedicine Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/8fe8c755433b4567a6e3431bbc49979f
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spelling	oai:doaj.org-article:8fe8c755433b4567a6e3431bbc49979f2021-11-08T06:37:13ZTwo-Dimensional Nanomaterials for Peripheral Nerve Engineering: Recent Advances and Potential Mechanisms2296-418510.3389/fbioe.2021.746074https://doaj.org/article/8fe8c755433b4567a6e3431bbc49979f2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fbioe.2021.746074/fullhttps://doaj.org/toc/2296-4185Peripheral nerve tissues possess the ability to regenerate within artificial nerve scaffolds, however, despite the advance of biomaterials that support nerve regeneration, the functional nerve recovery remains unsatisfactory. Importantly, the incorporation of two-dimensional nanomaterials has shown to significantly improve the therapeutic effect of conventional nerve scaffolds. In this review, we examine whether two-dimensional nanomaterials facilitate angiogenesis and thereby promote peripheral nerve regeneration. First, we summarize the major events occurring after peripheral nerve injury. Second, we discuss that the application of two-dimensional nanomaterials for peripheral nerve regeneration strategies by facilitating the formation of new vessels. Then, we analyze the mechanism that the newly-formed capillaries directionally and metabolically support neuronal regeneration. Finally, we prospect that the two-dimensional nanomaterials should be a potential solution to long range peripheral nerve defect. To further enhance the therapeutic effects of two-dimensional nanomaterial, strategies which help remedy the energy deficiency after peripheral nerve injury could be a viable solution.Zhiwen YanZhiwen YanZhiwen YanCheng ChenGonzalo RossoGonzalo RossoGonzalo RossoYun QianYun QianYun QianCunyi FanCunyi FanCunyi FanFrontiers Media S.A.articletwo-dimensional nanomaterialperipheral nerve regenerationnerve scaffoldnerve tissue engineeringangiogenesisnanomedicineBiotechnologyTP248.13-248.65ENFrontiers in Bioengineering and Biotechnology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	two-dimensional nanomaterial peripheral nerve regeneration nerve scaffold nerve tissue engineering angiogenesis nanomedicine Biotechnology TP248.13-248.65
spellingShingle	two-dimensional nanomaterial peripheral nerve regeneration nerve scaffold nerve tissue engineering angiogenesis nanomedicine Biotechnology TP248.13-248.65 Zhiwen Yan Zhiwen Yan Zhiwen Yan Cheng Chen Gonzalo Rosso Gonzalo Rosso Gonzalo Rosso Yun Qian Yun Qian Yun Qian Cunyi Fan Cunyi Fan Cunyi Fan Two-Dimensional Nanomaterials for Peripheral Nerve Engineering: Recent Advances and Potential Mechanisms
description	Peripheral nerve tissues possess the ability to regenerate within artificial nerve scaffolds, however, despite the advance of biomaterials that support nerve regeneration, the functional nerve recovery remains unsatisfactory. Importantly, the incorporation of two-dimensional nanomaterials has shown to significantly improve the therapeutic effect of conventional nerve scaffolds. In this review, we examine whether two-dimensional nanomaterials facilitate angiogenesis and thereby promote peripheral nerve regeneration. First, we summarize the major events occurring after peripheral nerve injury. Second, we discuss that the application of two-dimensional nanomaterials for peripheral nerve regeneration strategies by facilitating the formation of new vessels. Then, we analyze the mechanism that the newly-formed capillaries directionally and metabolically support neuronal regeneration. Finally, we prospect that the two-dimensional nanomaterials should be a potential solution to long range peripheral nerve defect. To further enhance the therapeutic effects of two-dimensional nanomaterial, strategies which help remedy the energy deficiency after peripheral nerve injury could be a viable solution.
format	article
author	Zhiwen Yan Zhiwen Yan Zhiwen Yan Cheng Chen Gonzalo Rosso Gonzalo Rosso Gonzalo Rosso Yun Qian Yun Qian Yun Qian Cunyi Fan Cunyi Fan Cunyi Fan
author_facet	Zhiwen Yan Zhiwen Yan Zhiwen Yan Cheng Chen Gonzalo Rosso Gonzalo Rosso Gonzalo Rosso Yun Qian Yun Qian Yun Qian Cunyi Fan Cunyi Fan Cunyi Fan
author_sort	Zhiwen Yan
title	Two-Dimensional Nanomaterials for Peripheral Nerve Engineering: Recent Advances and Potential Mechanisms
title_short	Two-Dimensional Nanomaterials for Peripheral Nerve Engineering: Recent Advances and Potential Mechanisms
title_full	Two-Dimensional Nanomaterials for Peripheral Nerve Engineering: Recent Advances and Potential Mechanisms
title_fullStr	Two-Dimensional Nanomaterials for Peripheral Nerve Engineering: Recent Advances and Potential Mechanisms
title_full_unstemmed	Two-Dimensional Nanomaterials for Peripheral Nerve Engineering: Recent Advances and Potential Mechanisms
title_sort	two-dimensional nanomaterials for peripheral nerve engineering: recent advances and potential mechanisms
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/8fe8c755433b4567a6e3431bbc49979f
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Two-Dimensional Nanomaterials for Peripheral Nerve Engineering: Recent Advances and Potential Mechanisms

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