Symptom experience of adverse drug reaction among male and female patients with newly diagnosed pulmonary tuberculosis in Thailand

Background: Patients with newly diagnosed pulmonary tuberculosis often suffer from adverse drug reaction symptoms, which leads to the automatic discontinuation of anti-tuberculosis drugs. Thus, understanding symptom experience of adverse drug reactions is necessary. Objective: This study aimed to ex...

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Autores principales:	Apichaya Thontham, Rapin Polsook
Formato:	article
Lenguaje:	EN
Publicado:	Belitung Raya Foundation 2021
Materias:	adverse drug reaction pulmonary tuberculosis symptom experiences quality of life drug-related side effects nursing thailand Nursing RT1-120
Acceso en línea:	https://doaj.org/article/8fe93a3f89fc49fdaa5ad9321313f81b
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spelling	oai:doaj.org-article:8fe93a3f89fc49fdaa5ad9321313f81b2021-12-02T18:03:38ZSymptom experience of adverse drug reaction among male and female patients with newly diagnosed pulmonary tuberculosis in Thailand2477-407310.33546/bnj.1337https://doaj.org/article/8fe93a3f89fc49fdaa5ad9321313f81b2021-06-01T00:00:00Zhttps://belitungraya.org/BRP/index.php/bnj/article/view/1337https://doaj.org/toc/2477-4073Background: Patients with newly diagnosed pulmonary tuberculosis often suffer from adverse drug reaction symptoms, which leads to the automatic discontinuation of anti-tuberculosis drugs. Thus, understanding symptom experience of adverse drug reactions is necessary. Objective: This study aimed to examine differences in symptoms experienced in four dimensions: presence, frequency, severity, and distress of adverse drug reactions, between male and female patients. Methods: This was a quantitative survey with a cross-sectional design, with data collected between January and April 2020. A total of 394 patients with newly diagnosed pulmonary tuberculosis was selected through a purposive sampling technique. The symptom experiences of adverse drug reactions were measured using a validated instrument. Data were analyzed using mean, standard deviation, and independent t-test. Results: The most commonly reported symptom was itchiness (24.1% in males and 34.9% in females). Vomiting occurred as the most frequent symptom among males (x̅ ± SD = 2.73 ± .88), and fatigue was found to be the most severe and distressing symptom across male patients (x̅ ± SD = 2.50 ± 1.61 and 2.06 ± 1.30, respectively). In contrast, yellowing of the eyes and skin was most frequent and severe among females (x̅ ± SD = 3.17 ± .75 and 3.83 ± 1.47, respectively). In addition, flu-like symptoms were evaluated as the most distressing symptom for female patients (x̅ ± SD = 2.80 ± 1.09). The symptom burdens of the females ranged significantly and reached higher than those of the male patients at a p-value of .05 (t = 3.33). Conclusion: Females taking anti-tuberculosis drugs should be carefully monitored to deal with adverse drug reaction symptoms. This finding would help to decrease the severity of disease and improve their quality of life. Funding: This study received funding from the Ratchadaphiseksomphot Endowment Fund, Chulalongkorn University, Bangkok, Thailand (GCUGR1125633058M).Apichaya ThonthamRapin PolsookBelitung Raya Foundationarticleadverse drug reactionpulmonary tuberculosissymptom experiencesquality of lifedrug-related side effectsnursingthailandNursingRT1-120ENBelitung Nursing Journal, Vol 7, Iss 3, Pp 195-202 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	adverse drug reaction pulmonary tuberculosis symptom experiences quality of life drug-related side effects nursing thailand Nursing RT1-120
spellingShingle	adverse drug reaction pulmonary tuberculosis symptom experiences quality of life drug-related side effects nursing thailand Nursing RT1-120 Apichaya Thontham Rapin Polsook Symptom experience of adverse drug reaction among male and female patients with newly diagnosed pulmonary tuberculosis in Thailand
description	Background: Patients with newly diagnosed pulmonary tuberculosis often suffer from adverse drug reaction symptoms, which leads to the automatic discontinuation of anti-tuberculosis drugs. Thus, understanding symptom experience of adverse drug reactions is necessary. Objective: This study aimed to examine differences in symptoms experienced in four dimensions: presence, frequency, severity, and distress of adverse drug reactions, between male and female patients. Methods: This was a quantitative survey with a cross-sectional design, with data collected between January and April 2020. A total of 394 patients with newly diagnosed pulmonary tuberculosis was selected through a purposive sampling technique. The symptom experiences of adverse drug reactions were measured using a validated instrument. Data were analyzed using mean, standard deviation, and independent t-test. Results: The most commonly reported symptom was itchiness (24.1% in males and 34.9% in females). Vomiting occurred as the most frequent symptom among males (x̅ ± SD = 2.73 ± .88), and fatigue was found to be the most severe and distressing symptom across male patients (x̅ ± SD = 2.50 ± 1.61 and 2.06 ± 1.30, respectively). In contrast, yellowing of the eyes and skin was most frequent and severe among females (x̅ ± SD = 3.17 ± .75 and 3.83 ± 1.47, respectively). In addition, flu-like symptoms were evaluated as the most distressing symptom for female patients (x̅ ± SD = 2.80 ± 1.09). The symptom burdens of the females ranged significantly and reached higher than those of the male patients at a p-value of .05 (t = 3.33). Conclusion: Females taking anti-tuberculosis drugs should be carefully monitored to deal with adverse drug reaction symptoms. This finding would help to decrease the severity of disease and improve their quality of life. Funding: This study received funding from the Ratchadaphiseksomphot Endowment Fund, Chulalongkorn University, Bangkok, Thailand (GCUGR1125633058M).
format	article
author	Apichaya Thontham Rapin Polsook
author_facet	Apichaya Thontham Rapin Polsook
author_sort	Apichaya Thontham
title	Symptom experience of adverse drug reaction among male and female patients with newly diagnosed pulmonary tuberculosis in Thailand
title_short	Symptom experience of adverse drug reaction among male and female patients with newly diagnosed pulmonary tuberculosis in Thailand
title_full	Symptom experience of adverse drug reaction among male and female patients with newly diagnosed pulmonary tuberculosis in Thailand
title_fullStr	Symptom experience of adverse drug reaction among male and female patients with newly diagnosed pulmonary tuberculosis in Thailand
title_full_unstemmed	Symptom experience of adverse drug reaction among male and female patients with newly diagnosed pulmonary tuberculosis in Thailand
title_sort	symptom experience of adverse drug reaction among male and female patients with newly diagnosed pulmonary tuberculosis in thailand
publisher	Belitung Raya Foundation
publishDate	2021
url	https://doaj.org/article/8fe93a3f89fc49fdaa5ad9321313f81b
work_keys_str_mv	AT apichayathontham symptomexperienceofadversedrugreactionamongmaleandfemalepatientswithnewlydiagnosedpulmonarytuberculosisinthailand AT rapinpolsook symptomexperienceofadversedrugreactionamongmaleandfemalepatientswithnewlydiagnosedpulmonarytuberculosisinthailand
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Symptom experience of adverse drug reaction among male and female patients with newly diagnosed pulmonary tuberculosis in Thailand

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