Diagnosis and staging of fibrosis in patients with chronic hepatitis C: comparison and critical overview of current strategies

Leandro César Mendes, Raquel SB Stucchi, Aline G Vigani Department of Infectious Diseases, State University of Campinas, Campinas, SP, Brazil Abstract: In the past years, what has always been considered undisputed true in liver fibrosis staging has been challenged. Diagnostic performance...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Mendes LC, Stucchi RSB, Vigani AG
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	chronic hepatitis C fibrosis staging elastography biomarkers Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/8feab77c7a024ef18c1ee775ab706ce0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8feab77c7a024ef18c1ee775ab706ce0
record_format	dspace
spelling	oai:doaj.org-article:8feab77c7a024ef18c1ee775ab706ce02021-12-02T02:17:14ZDiagnosis and staging of fibrosis in patients with chronic hepatitis C: comparison and critical overview of current strategies1179-1535https://doaj.org/article/8feab77c7a024ef18c1ee775ab706ce02018-04-01T00:00:00Zhttps://www.dovepress.com/diagnosis-and-staging-of-fibrosis-in-patients-with-chronic-hepatitis-c-peer-reviewed-article-HMERhttps://doaj.org/toc/1179-1535Leandro César Mendes, Raquel SB Stucchi, Aline G Vigani Department of Infectious Diseases, State University of Campinas, Campinas, SP, Brazil Abstract: In the past years, what has always been considered undisputed true in liver fibrosis staging has been challenged. Diagnostic performance of histological evaluation has proven to be significantly influenced by sample- and observer-related variabilities. Differentiation between lower levels of fibrosis remains difficult for many, if not all, test modalities, including liver biopsy but, perhaps, such a distinction is not indispensable in light of current therapeutic approaches. Biomarkers and elastography offer, nonetheless, high predictive values for advanced fibrosis and cirrhosis and correlate well with liver-related outcomes. Necroinflammation, steatosis, and hemodynamic changes may significantly interfere with elastography-based techniques, and longitudinal follow-up strategies must be tailored in light of these findings. Knowledge of different test modalities and diagnostic performance indicators can allow for better clinical decision-making and resource allocation. Keywords: chronic hepatitis C, fibrosis, staging, elastography, biomarkersMendes LCStucchi RSBVigani AGDove Medical Pressarticlechronic hepatitis CfibrosisstagingelastographybiomarkersDiseases of the digestive system. GastroenterologyRC799-869ENHepatic Medicine: Evidence and Research, Vol Volume 10, Pp 13-22 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	chronic hepatitis C fibrosis staging elastography biomarkers Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	chronic hepatitis C fibrosis staging elastography biomarkers Diseases of the digestive system. Gastroenterology RC799-869 Mendes LC Stucchi RSB Vigani AG Diagnosis and staging of fibrosis in patients with chronic hepatitis C: comparison and critical overview of current strategies
description	Leandro César Mendes, Raquel SB Stucchi, Aline G Vigani Department of Infectious Diseases, State University of Campinas, Campinas, SP, Brazil Abstract: In the past years, what has always been considered undisputed true in liver fibrosis staging has been challenged. Diagnostic performance of histological evaluation has proven to be significantly influenced by sample- and observer-related variabilities. Differentiation between lower levels of fibrosis remains difficult for many, if not all, test modalities, including liver biopsy but, perhaps, such a distinction is not indispensable in light of current therapeutic approaches. Biomarkers and elastography offer, nonetheless, high predictive values for advanced fibrosis and cirrhosis and correlate well with liver-related outcomes. Necroinflammation, steatosis, and hemodynamic changes may significantly interfere with elastography-based techniques, and longitudinal follow-up strategies must be tailored in light of these findings. Knowledge of different test modalities and diagnostic performance indicators can allow for better clinical decision-making and resource allocation. Keywords: chronic hepatitis C, fibrosis, staging, elastography, biomarkers
format	article
author	Mendes LC Stucchi RSB Vigani AG
author_facet	Mendes LC Stucchi RSB Vigani AG
author_sort	Mendes LC
title	Diagnosis and staging of fibrosis in patients with chronic hepatitis C: comparison and critical overview of current strategies
title_short	Diagnosis and staging of fibrosis in patients with chronic hepatitis C: comparison and critical overview of current strategies
title_full	Diagnosis and staging of fibrosis in patients with chronic hepatitis C: comparison and critical overview of current strategies
title_fullStr	Diagnosis and staging of fibrosis in patients with chronic hepatitis C: comparison and critical overview of current strategies
title_full_unstemmed	Diagnosis and staging of fibrosis in patients with chronic hepatitis C: comparison and critical overview of current strategies
title_sort	diagnosis and staging of fibrosis in patients with chronic hepatitis c: comparison and critical overview of current strategies
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/8feab77c7a024ef18c1ee775ab706ce0
work_keys_str_mv	AT mendeslc diagnosisandstagingoffibrosisinpatientswithchronichepatitisccomparisonandcriticaloverviewofcurrentstrategies AT stucchirsb diagnosisandstagingoffibrosisinpatientswithchronichepatitisccomparisonandcriticaloverviewofcurrentstrategies AT viganiag diagnosisandstagingoffibrosisinpatientswithchronichepatitisccomparisonandcriticaloverviewofcurrentstrategies
_version_	1718402609375608832

Diagnosis and staging of fibrosis in patients with chronic hepatitis C: comparison and critical overview of current strategies

Ejemplares similares