PHA-4/FoxA senses nucleolar stress to regulate lipid accumulation in Caenorhabditis elegans

Nucleolar stress can disrupt ribosome biogenesis and in turn energy metabolism and lipid storage, but how this is regulated is unclear. Here, the authors show in C. elegans that the transcription factor PHA-4/FOXA acts as a sensor for nucleolar stress and can regulate expression of lipogenic genes

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Auteurs principaux:	Jieyu Wu, Xue Jiang, Yamei Li, Tingting Zhu, Jingjing Zhang, Zhiguo Zhang, Linqiang Zhang, Yuru Zhang, Yanli Wang, Xiaoju Zou, Bin Liang
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2018
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/8febfb2911a04f22ae3b3b04afe66b4b
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spelling	oai:doaj.org-article:8febfb2911a04f22ae3b3b04afe66b4b2021-12-02T14:38:48ZPHA-4/FoxA senses nucleolar stress to regulate lipid accumulation in Caenorhabditis elegans10.1038/s41467-018-03531-22041-1723https://doaj.org/article/8febfb2911a04f22ae3b3b04afe66b4b2018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03531-2https://doaj.org/toc/2041-1723Nucleolar stress can disrupt ribosome biogenesis and in turn energy metabolism and lipid storage, but how this is regulated is unclear. Here, the authors show in C. elegans that the transcription factor PHA-4/FOXA acts as a sensor for nucleolar stress and can regulate expression of lipogenic genesJieyu WuXue JiangYamei LiTingting ZhuJingjing ZhangZhiguo ZhangLinqiang ZhangYuru ZhangYanli WangXiaoju ZouBin LiangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jieyu Wu Xue Jiang Yamei Li Tingting Zhu Jingjing Zhang Zhiguo Zhang Linqiang Zhang Yuru Zhang Yanli Wang Xiaoju Zou Bin Liang PHA-4/FoxA senses nucleolar stress to regulate lipid accumulation in Caenorhabditis elegans
description	Nucleolar stress can disrupt ribosome biogenesis and in turn energy metabolism and lipid storage, but how this is regulated is unclear. Here, the authors show in C. elegans that the transcription factor PHA-4/FOXA acts as a sensor for nucleolar stress and can regulate expression of lipogenic genes
format	article
author	Jieyu Wu Xue Jiang Yamei Li Tingting Zhu Jingjing Zhang Zhiguo Zhang Linqiang Zhang Yuru Zhang Yanli Wang Xiaoju Zou Bin Liang
author_facet	Jieyu Wu Xue Jiang Yamei Li Tingting Zhu Jingjing Zhang Zhiguo Zhang Linqiang Zhang Yuru Zhang Yanli Wang Xiaoju Zou Bin Liang
author_sort	Jieyu Wu
title	PHA-4/FoxA senses nucleolar stress to regulate lipid accumulation in Caenorhabditis elegans
title_short	PHA-4/FoxA senses nucleolar stress to regulate lipid accumulation in Caenorhabditis elegans
title_full	PHA-4/FoxA senses nucleolar stress to regulate lipid accumulation in Caenorhabditis elegans
title_fullStr	PHA-4/FoxA senses nucleolar stress to regulate lipid accumulation in Caenorhabditis elegans
title_full_unstemmed	PHA-4/FoxA senses nucleolar stress to regulate lipid accumulation in Caenorhabditis elegans
title_sort	pha-4/foxa senses nucleolar stress to regulate lipid accumulation in caenorhabditis elegans
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/8febfb2911a04f22ae3b3b04afe66b4b
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PHA-4/FoxA senses nucleolar stress to regulate lipid accumulation in Caenorhabditis elegans

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