Clinical Cohort Study in Canine Patients, to Determine the Average Platelet and White Blood Cell Number and Its Correlation with Patient’s Age, Weight, Breed and Gender: 92 Cases (2019–2020)

Due to its easy preparation and that it is well tolerated, the use of autologous platelet-rich plasma (PRP) has become increasingly popular in regenerative medicine. However, there are still no clear guidelines on how it should be classified or whether the individual canine patient’s clinical status...

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Autores principales:	Isabel de Marcos Carpio, Anita Sanghani-Kerai, Miguel A. Solano, Gordon Blunn, Alexandra Jifcovici, Noel Fitzpatrick
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	platelet-rich plasma regenerative therapy platelets white blood cells canine degenerative Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/8ff0c3b09dc24ccb8fe46cdee31534d0
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spelling	oai:doaj.org-article:8ff0c3b09dc24ccb8fe46cdee31534d02021-11-25T19:11:58ZClinical Cohort Study in Canine Patients, to Determine the Average Platelet and White Blood Cell Number and Its Correlation with Patient’s Age, Weight, Breed and Gender: 92 Cases (2019–2020)10.3390/vetsci81102622306-7381https://doaj.org/article/8ff0c3b09dc24ccb8fe46cdee31534d02021-11-01T00:00:00Zhttps://www.mdpi.com/2306-7381/8/11/262https://doaj.org/toc/2306-7381Due to its easy preparation and that it is well tolerated, the use of autologous platelet-rich plasma (PRP) has become increasingly popular in regenerative medicine. However, there are still no clear guidelines on how it should be classified or whether the individual canine patient’s clinical status can influence its quality. Objective: This study aims to show if the weight, age, sex, neutered status or breed of canine patients have any correlation with the composition of PRP. Design: A blinded count of the platelets and white blood cells (WBC) was performed from 111 samples from 92 client owned dogs undergoing treatment for degenerative joint disease (DJD). The results were analysed using Pearson correlation test, ANOVA test or Student <i>T</i>-test. Results: There is a positive correlation between the number of platelets and WBC in canine patients of different breeds, but there was no significant difference on the platelet number and WBC number among the different breeds. The weight of the patient is also directly correlated to the platelet number (<i>p</i> = 0.003) but not WBC number. WBC number was negatively correlated to the weight of the patient. The sex and age of the patient did not affect platelets and WBC number, although WBC number is increased in non-neutered male population (<i>p</i> = 0.003). However, it would be interesting to investigate whether the growth factors released from the platelet granules are affected by patient variables in a canine population. Conclusions: Our results show that it is possible to obtain good quality autologous PRP, irrespective of age, sex, neutered status or weight of the patient, for PRP regenerative therapy.Isabel de Marcos CarpioAnita Sanghani-KeraiMiguel A. SolanoGordon BlunnAlexandra JifcoviciNoel FitzpatrickMDPI AGarticleplatelet-rich plasmaregenerative therapyplateletswhite blood cellscaninedegenerativeVeterinary medicineSF600-1100ENVeterinary Sciences, Vol 8, Iss 262, p 262 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	platelet-rich plasma regenerative therapy platelets white blood cells canine degenerative Veterinary medicine SF600-1100
spellingShingle	platelet-rich plasma regenerative therapy platelets white blood cells canine degenerative Veterinary medicine SF600-1100 Isabel de Marcos Carpio Anita Sanghani-Kerai Miguel A. Solano Gordon Blunn Alexandra Jifcovici Noel Fitzpatrick Clinical Cohort Study in Canine Patients, to Determine the Average Platelet and White Blood Cell Number and Its Correlation with Patient’s Age, Weight, Breed and Gender: 92 Cases (2019–2020)
description	Due to its easy preparation and that it is well tolerated, the use of autologous platelet-rich plasma (PRP) has become increasingly popular in regenerative medicine. However, there are still no clear guidelines on how it should be classified or whether the individual canine patient’s clinical status can influence its quality. Objective: This study aims to show if the weight, age, sex, neutered status or breed of canine patients have any correlation with the composition of PRP. Design: A blinded count of the platelets and white blood cells (WBC) was performed from 111 samples from 92 client owned dogs undergoing treatment for degenerative joint disease (DJD). The results were analysed using Pearson correlation test, ANOVA test or Student <i>T</i>-test. Results: There is a positive correlation between the number of platelets and WBC in canine patients of different breeds, but there was no significant difference on the platelet number and WBC number among the different breeds. The weight of the patient is also directly correlated to the platelet number (<i>p</i> = 0.003) but not WBC number. WBC number was negatively correlated to the weight of the patient. The sex and age of the patient did not affect platelets and WBC number, although WBC number is increased in non-neutered male population (<i>p</i> = 0.003). However, it would be interesting to investigate whether the growth factors released from the platelet granules are affected by patient variables in a canine population. Conclusions: Our results show that it is possible to obtain good quality autologous PRP, irrespective of age, sex, neutered status or weight of the patient, for PRP regenerative therapy.
format	article
author	Isabel de Marcos Carpio Anita Sanghani-Kerai Miguel A. Solano Gordon Blunn Alexandra Jifcovici Noel Fitzpatrick
author_facet	Isabel de Marcos Carpio Anita Sanghani-Kerai Miguel A. Solano Gordon Blunn Alexandra Jifcovici Noel Fitzpatrick
author_sort	Isabel de Marcos Carpio
title	Clinical Cohort Study in Canine Patients, to Determine the Average Platelet and White Blood Cell Number and Its Correlation with Patient’s Age, Weight, Breed and Gender: 92 Cases (2019–2020)
title_short	Clinical Cohort Study in Canine Patients, to Determine the Average Platelet and White Blood Cell Number and Its Correlation with Patient’s Age, Weight, Breed and Gender: 92 Cases (2019–2020)
title_full	Clinical Cohort Study in Canine Patients, to Determine the Average Platelet and White Blood Cell Number and Its Correlation with Patient’s Age, Weight, Breed and Gender: 92 Cases (2019–2020)
title_fullStr	Clinical Cohort Study in Canine Patients, to Determine the Average Platelet and White Blood Cell Number and Its Correlation with Patient’s Age, Weight, Breed and Gender: 92 Cases (2019–2020)
title_full_unstemmed	Clinical Cohort Study in Canine Patients, to Determine the Average Platelet and White Blood Cell Number and Its Correlation with Patient’s Age, Weight, Breed and Gender: 92 Cases (2019–2020)
title_sort	clinical cohort study in canine patients, to determine the average platelet and white blood cell number and its correlation with patient’s age, weight, breed and gender: 92 cases (2019–2020)
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/8ff0c3b09dc24ccb8fe46cdee31534d0
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Clinical Cohort Study in Canine Patients, to Determine the Average Platelet and White Blood Cell Number and Its Correlation with Patient’s Age, Weight, Breed and Gender: 92 Cases (2019–2020)

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