Znhit1 controls intestinal stem cell maintenance by regulating H2A.Z incorporation

Znhit1 controls intestinal stem cell maintenance by regulating H2A.Z incorporation

Lgr5+ stem cells in intestinal crypts are critical for gut epithelium homeostasis. Here, the authors show that Znht1 critically regulates intestinal homeostasis by promoting interaction between histone variant H2A.Z and its chaperone YL1 to incorporate H2A.Z into genes involved in intestinal stem ce...

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Autores principales: Bing Zhao, Ying Chen, Ning Jiang, Li Yang, Shenfei Sun, Yan Zhang, Zengqi Wen, Lorraine Ray, Han Liu, Guoli Hou, Xinhua Lin
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Q
Acceso en línea:https://doaj.org/article/8ff28e5c8ddf474a853435819bbaaa66
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spelling oai:doaj.org-article:8ff28e5c8ddf474a853435819bbaaa662021-12-02T17:01:26ZZnhit1 controls intestinal stem cell maintenance by regulating H2A.Z incorporation10.1038/s41467-019-09060-w2041-1723https://doaj.org/article/8ff28e5c8ddf474a853435819bbaaa662019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09060-whttps://doaj.org/toc/2041-1723Lgr5+ stem cells in intestinal crypts are critical for gut epithelium homeostasis. Here, the authors show that Znht1 critically regulates intestinal homeostasis by promoting interaction between histone variant H2A.Z and its chaperone YL1 to incorporate H2A.Z into genes involved in intestinal stem cell fate.Bing ZhaoYing ChenNing JiangLi YangShenfei SunYan ZhangZengqi WenLorraine RayHan LiuGuoli HouXinhua LinNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Bing Zhao
Ying Chen
Ning Jiang
Li Yang
Shenfei Sun
Yan Zhang
Zengqi Wen
Lorraine Ray
Han Liu
Guoli Hou
Xinhua Lin
Znhit1 controls intestinal stem cell maintenance by regulating H2A.Z incorporation
description Lgr5+ stem cells in intestinal crypts are critical for gut epithelium homeostasis. Here, the authors show that Znht1 critically regulates intestinal homeostasis by promoting interaction between histone variant H2A.Z and its chaperone YL1 to incorporate H2A.Z into genes involved in intestinal stem cell fate.
format article
author Bing Zhao
Ying Chen
Ning Jiang
Li Yang
Shenfei Sun
Yan Zhang
Zengqi Wen
Lorraine Ray
Han Liu
Guoli Hou
Xinhua Lin
author_facet Bing Zhao
Ying Chen
Ning Jiang
Li Yang
Shenfei Sun
Yan Zhang
Zengqi Wen
Lorraine Ray
Han Liu
Guoli Hou
Xinhua Lin
author_sort Bing Zhao
title Znhit1 controls intestinal stem cell maintenance by regulating H2A.Z incorporation
title_short Znhit1 controls intestinal stem cell maintenance by regulating H2A.Z incorporation
title_full Znhit1 controls intestinal stem cell maintenance by regulating H2A.Z incorporation
title_fullStr Znhit1 controls intestinal stem cell maintenance by regulating H2A.Z incorporation
title_full_unstemmed Znhit1 controls intestinal stem cell maintenance by regulating H2A.Z incorporation
title_sort znhit1 controls intestinal stem cell maintenance by regulating h2a.z incorporation
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/8ff28e5c8ddf474a853435819bbaaa66
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AT ningjiang znhit1controlsintestinalstemcellmaintenancebyregulatingh2azincorporation
AT liyang znhit1controlsintestinalstemcellmaintenancebyregulatingh2azincorporation
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AT lorraineray znhit1controlsintestinalstemcellmaintenancebyregulatingh2azincorporation
AT hanliu znhit1controlsintestinalstemcellmaintenancebyregulatingh2azincorporation
AT guolihou znhit1controlsintestinalstemcellmaintenancebyregulatingh2azincorporation
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