Znhit1 controls intestinal stem cell maintenance by regulating H2A.Z incorporation

Znhit1 controls intestinal stem cell maintenance by regulating H2A.Z incorporation

Lgr5+ stem cells in intestinal crypts are critical for gut epithelium homeostasis. Here, the authors show that Znht1 critically regulates intestinal homeostasis by promoting interaction between histone variant H2A.Z and its chaperone YL1 to incorporate H2A.Z into genes involved in intestinal stem ce...

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Autores principales: Bing Zhao, Ying Chen, Ning Jiang, Li Yang, Shenfei Sun, Yan Zhang, Zengqi Wen, Lorraine Ray, Han Liu, Guoli Hou, Xinhua Lin
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/8ff28e5c8ddf474a853435819bbaaa66
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