The impact of endothelial progenitor cells on restenosis after percutaneous angioplasty of hemodialysis vascular access.

<h4>Objective</h4>We prospectively investigate the relation between baseline circulating endothelial progenitor cells and the subsequent development of restenosis after angioplasty of hemodialysis vascular access.<h4>Background</h4>Effect of angioplasty for hemodialysis vascu...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Chih-Cheng Wu, Po-Hsun Huang, Chao-Lun Lai, Hsin-Bang Leu, Jaw-Wen Chen, Shing-Jong Lin
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8ff290d1212543cd89b325bdb4a06b90
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8ff290d1212543cd89b325bdb4a06b90
record_format	dspace
spelling	oai:doaj.org-article:8ff290d1212543cd89b325bdb4a06b902021-11-11T08:21:33ZThe impact of endothelial progenitor cells on restenosis after percutaneous angioplasty of hemodialysis vascular access.1932-620310.1371/journal.pone.0101058https://doaj.org/article/8ff290d1212543cd89b325bdb4a06b902014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24964143/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>We prospectively investigate the relation between baseline circulating endothelial progenitor cells and the subsequent development of restenosis after angioplasty of hemodialysis vascular access.<h4>Background</h4>Effect of angioplasty for hemodialysis vascular access is greatly attenuated by early and frequent restenosis. Circulating endothelial progenitor cells (EPCs) play a key role in vascular repair but are deficient in hemodialysis patients.<h4>Method</h4>After excluding 14 patients due to arterial stenosis, central vein stenosis, and failed angioplasty, 130 patients undergoing angioplasty for dysfunctional vascular access were prospectively enrolled. Flow cytometry with quantification of EPC markers (defined as CD34+, CD34+KDR+, CD34+KDR+CD133+) in peripheral blood immediately before angioplasty procedures was used to assess circulating EPC numbers. Patients were followed clinically for up to one year after angioplasty.<h4>Results</h4>During the one-year follow-up, 95 patients (73%) received interventions for recurrent access dysfunction. Patients in the lower tertile of CD34+KDR+ cell count had the highest restenosis rates (46%) at three month (early restenosis), compared with patients in the medium and upper tertiles of CD34+KDR+ cell count (27% and 12% respectively, p = 0.002). Patients in the lower tertile of CD34+KDR+ cell count received more re-interventions during one year. Patients with early restenosis had impaired EPC adhesive function and increased senescence and apoptosis. In multivariate analysis, the CD34+KDR+ and CD34+KDR+CD133+ cell counts were independent predictors of target-lesion early restenosis.<h4>Conclusion</h4>Our results suggest that the deficiency of circulating EPCs is associated with early and frequent restenosis after angioplasty of hemodialysis vascular access.Chih-Cheng WuPo-Hsun HuangChao-Lun LaiHsin-Bang LeuJaw-Wen ChenShing-Jong LinPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 6, p e101058 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chih-Cheng Wu Po-Hsun Huang Chao-Lun Lai Hsin-Bang Leu Jaw-Wen Chen Shing-Jong Lin The impact of endothelial progenitor cells on restenosis after percutaneous angioplasty of hemodialysis vascular access.
description	<h4>Objective</h4>We prospectively investigate the relation between baseline circulating endothelial progenitor cells and the subsequent development of restenosis after angioplasty of hemodialysis vascular access.<h4>Background</h4>Effect of angioplasty for hemodialysis vascular access is greatly attenuated by early and frequent restenosis. Circulating endothelial progenitor cells (EPCs) play a key role in vascular repair but are deficient in hemodialysis patients.<h4>Method</h4>After excluding 14 patients due to arterial stenosis, central vein stenosis, and failed angioplasty, 130 patients undergoing angioplasty for dysfunctional vascular access were prospectively enrolled. Flow cytometry with quantification of EPC markers (defined as CD34+, CD34+KDR+, CD34+KDR+CD133+) in peripheral blood immediately before angioplasty procedures was used to assess circulating EPC numbers. Patients were followed clinically for up to one year after angioplasty.<h4>Results</h4>During the one-year follow-up, 95 patients (73%) received interventions for recurrent access dysfunction. Patients in the lower tertile of CD34+KDR+ cell count had the highest restenosis rates (46%) at three month (early restenosis), compared with patients in the medium and upper tertiles of CD34+KDR+ cell count (27% and 12% respectively, p = 0.002). Patients in the lower tertile of CD34+KDR+ cell count received more re-interventions during one year. Patients with early restenosis had impaired EPC adhesive function and increased senescence and apoptosis. In multivariate analysis, the CD34+KDR+ and CD34+KDR+CD133+ cell counts were independent predictors of target-lesion early restenosis.<h4>Conclusion</h4>Our results suggest that the deficiency of circulating EPCs is associated with early and frequent restenosis after angioplasty of hemodialysis vascular access.
format	article
author	Chih-Cheng Wu Po-Hsun Huang Chao-Lun Lai Hsin-Bang Leu Jaw-Wen Chen Shing-Jong Lin
author_facet	Chih-Cheng Wu Po-Hsun Huang Chao-Lun Lai Hsin-Bang Leu Jaw-Wen Chen Shing-Jong Lin
author_sort	Chih-Cheng Wu
title	The impact of endothelial progenitor cells on restenosis after percutaneous angioplasty of hemodialysis vascular access.
title_short	The impact of endothelial progenitor cells on restenosis after percutaneous angioplasty of hemodialysis vascular access.
title_full	The impact of endothelial progenitor cells on restenosis after percutaneous angioplasty of hemodialysis vascular access.
title_fullStr	The impact of endothelial progenitor cells on restenosis after percutaneous angioplasty of hemodialysis vascular access.
title_full_unstemmed	The impact of endothelial progenitor cells on restenosis after percutaneous angioplasty of hemodialysis vascular access.
title_sort	impact of endothelial progenitor cells on restenosis after percutaneous angioplasty of hemodialysis vascular access.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/8ff290d1212543cd89b325bdb4a06b90
work_keys_str_mv	AT chihchengwu theimpactofendothelialprogenitorcellsonrestenosisafterpercutaneousangioplastyofhemodialysisvascularaccess AT pohsunhuang theimpactofendothelialprogenitorcellsonrestenosisafterpercutaneousangioplastyofhemodialysisvascularaccess AT chaolunlai theimpactofendothelialprogenitorcellsonrestenosisafterpercutaneousangioplastyofhemodialysisvascularaccess AT hsinbangleu theimpactofendothelialprogenitorcellsonrestenosisafterpercutaneousangioplastyofhemodialysisvascularaccess AT jawwenchen theimpactofendothelialprogenitorcellsonrestenosisafterpercutaneousangioplastyofhemodialysisvascularaccess AT shingjonglin theimpactofendothelialprogenitorcellsonrestenosisafterpercutaneousangioplastyofhemodialysisvascularaccess AT chihchengwu impactofendothelialprogenitorcellsonrestenosisafterpercutaneousangioplastyofhemodialysisvascularaccess AT pohsunhuang impactofendothelialprogenitorcellsonrestenosisafterpercutaneousangioplastyofhemodialysisvascularaccess AT chaolunlai impactofendothelialprogenitorcellsonrestenosisafterpercutaneousangioplastyofhemodialysisvascularaccess AT hsinbangleu impactofendothelialprogenitorcellsonrestenosisafterpercutaneousangioplastyofhemodialysisvascularaccess AT jawwenchen impactofendothelialprogenitorcellsonrestenosisafterpercutaneousangioplastyofhemodialysisvascularaccess AT shingjonglin impactofendothelialprogenitorcellsonrestenosisafterpercutaneousangioplastyofhemodialysisvascularaccess
_version_	1718439331239034880

The impact of endothelial progenitor cells on restenosis after percutaneous angioplasty of hemodialysis vascular access.

Ejemplares similares