BK channels in microglia are required for morphine-induced hyperalgesia

Long-term use of opioids can lead to a paradoxical increase in pain sensitivity. Here, Hayashi et al. link activation of potassium channels on microglia with morphine-induced hyperalgesia and anti-nociceptive tolerance in mice.

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Autores principales:	Yoshinori Hayashi, Saori Morinaga, Jing Zhang, Yasushi Satoh, Andrea L. Meredith, Takahiro Nakata, Zhou Wu, Shinichi Kohsaka, Kazuhide Inoue, Hiroshi Nakanishi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8ff4d6db63f3455b927a9ea1c5b258e8
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spelling	oai:doaj.org-article:8ff4d6db63f3455b927a9ea1c5b258e82021-12-02T16:49:43ZBK channels in microglia are required for morphine-induced hyperalgesia10.1038/ncomms116972041-1723https://doaj.org/article/8ff4d6db63f3455b927a9ea1c5b258e82016-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms11697https://doaj.org/toc/2041-1723Long-term use of opioids can lead to a paradoxical increase in pain sensitivity. Here, Hayashi et al. link activation of potassium channels on microglia with morphine-induced hyperalgesia and anti-nociceptive tolerance in mice.Yoshinori HayashiSaori MorinagaJing ZhangYasushi SatohAndrea L. MeredithTakahiro NakataZhou WuShinichi KohsakaKazuhide InoueHiroshi NakanishiNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yoshinori Hayashi Saori Morinaga Jing Zhang Yasushi Satoh Andrea L. Meredith Takahiro Nakata Zhou Wu Shinichi Kohsaka Kazuhide Inoue Hiroshi Nakanishi BK channels in microglia are required for morphine-induced hyperalgesia
description	Long-term use of opioids can lead to a paradoxical increase in pain sensitivity. Here, Hayashi et al. link activation of potassium channels on microglia with morphine-induced hyperalgesia and anti-nociceptive tolerance in mice.
format	article
author	Yoshinori Hayashi Saori Morinaga Jing Zhang Yasushi Satoh Andrea L. Meredith Takahiro Nakata Zhou Wu Shinichi Kohsaka Kazuhide Inoue Hiroshi Nakanishi
author_facet	Yoshinori Hayashi Saori Morinaga Jing Zhang Yasushi Satoh Andrea L. Meredith Takahiro Nakata Zhou Wu Shinichi Kohsaka Kazuhide Inoue Hiroshi Nakanishi
author_sort	Yoshinori Hayashi
title	BK channels in microglia are required for morphine-induced hyperalgesia
title_short	BK channels in microglia are required for morphine-induced hyperalgesia
title_full	BK channels in microglia are required for morphine-induced hyperalgesia
title_fullStr	BK channels in microglia are required for morphine-induced hyperalgesia
title_full_unstemmed	BK channels in microglia are required for morphine-induced hyperalgesia
title_sort	bk channels in microglia are required for morphine-induced hyperalgesia
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/8ff4d6db63f3455b927a9ea1c5b258e8
work_keys_str_mv	AT yoshinorihayashi bkchannelsinmicrogliaarerequiredformorphineinducedhyperalgesia AT saorimorinaga bkchannelsinmicrogliaarerequiredformorphineinducedhyperalgesia AT jingzhang bkchannelsinmicrogliaarerequiredformorphineinducedhyperalgesia AT yasushisatoh bkchannelsinmicrogliaarerequiredformorphineinducedhyperalgesia AT andrealmeredith bkchannelsinmicrogliaarerequiredformorphineinducedhyperalgesia AT takahironakata bkchannelsinmicrogliaarerequiredformorphineinducedhyperalgesia AT zhouwu bkchannelsinmicrogliaarerequiredformorphineinducedhyperalgesia AT shinichikohsaka bkchannelsinmicrogliaarerequiredformorphineinducedhyperalgesia AT kazuhideinoue bkchannelsinmicrogliaarerequiredformorphineinducedhyperalgesia AT hiroshinakanishi bkchannelsinmicrogliaarerequiredformorphineinducedhyperalgesia
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BK channels in microglia are required for morphine-induced hyperalgesia

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