A recurrent kinase domain mutation in PRKCA defines chordoid glioma of the third ventricle
Chordoid glioma is a rare low-grade brain tumor that originates from the anterior wall of the third ventricle where surgical resection is challenging; the clinical outcome of patients after subtotal resection or disease recurrence is poor. Here the authors identify a recurrent missense mutation in P...
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Nature Portfolio
2018
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oai:doaj.org-article:8ff58d0463294f3b9772e2541cb2ebc52021-12-02T17:31:46ZA recurrent kinase domain mutation in PRKCA defines chordoid glioma of the third ventricle10.1038/s41467-018-02826-82041-1723https://doaj.org/article/8ff58d0463294f3b9772e2541cb2ebc52018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-02826-8https://doaj.org/toc/2041-1723Chordoid glioma is a rare low-grade brain tumor that originates from the anterior wall of the third ventricle where surgical resection is challenging; the clinical outcome of patients after subtotal resection or disease recurrence is poor. Here the authors identify a recurrent missense mutation in PRKCA that may serve as a potential therapeutic target in this uncommon brain cancer.Benjamin GoodeGourish MondalMichael HyunDiego Garrido RuizYu-Hsiu LinJessica Van ZiffleNancy M. JosephCourtney OnoderaEric TalevichJames P. GrenertIman H. HewediMatija SnuderlDaniel J. BratBette K. Kleinschmidt-DeMastersFausto J. RodriguezDavid N. LouisWilliam H. YongM. Beatriz LopesMarc K. RosenblumNicholas ButowskiTarik TihanAndrew W. BollenJoanna J. PhillipsArun P. WiitaIwei YehMatthew P. JacobsonBoris C. BastianArie PerryDavid A. SolomonNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-8 (2018) |
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EN |
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Science Q |
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Science Q Benjamin Goode Gourish Mondal Michael Hyun Diego Garrido Ruiz Yu-Hsiu Lin Jessica Van Ziffle Nancy M. Joseph Courtney Onodera Eric Talevich James P. Grenert Iman H. Hewedi Matija Snuderl Daniel J. Brat Bette K. Kleinschmidt-DeMasters Fausto J. Rodriguez David N. Louis William H. Yong M. Beatriz Lopes Marc K. Rosenblum Nicholas Butowski Tarik Tihan Andrew W. Bollen Joanna J. Phillips Arun P. Wiita Iwei Yeh Matthew P. Jacobson Boris C. Bastian Arie Perry David A. Solomon A recurrent kinase domain mutation in PRKCA defines chordoid glioma of the third ventricle |
| description |
Chordoid glioma is a rare low-grade brain tumor that originates from the anterior wall of the third ventricle where surgical resection is challenging; the clinical outcome of patients after subtotal resection or disease recurrence is poor. Here the authors identify a recurrent missense mutation in PRKCA that may serve as a potential therapeutic target in this uncommon brain cancer. |
| format |
article |
| author |
Benjamin Goode Gourish Mondal Michael Hyun Diego Garrido Ruiz Yu-Hsiu Lin Jessica Van Ziffle Nancy M. Joseph Courtney Onodera Eric Talevich James P. Grenert Iman H. Hewedi Matija Snuderl Daniel J. Brat Bette K. Kleinschmidt-DeMasters Fausto J. Rodriguez David N. Louis William H. Yong M. Beatriz Lopes Marc K. Rosenblum Nicholas Butowski Tarik Tihan Andrew W. Bollen Joanna J. Phillips Arun P. Wiita Iwei Yeh Matthew P. Jacobson Boris C. Bastian Arie Perry David A. Solomon |
| author_facet |
Benjamin Goode Gourish Mondal Michael Hyun Diego Garrido Ruiz Yu-Hsiu Lin Jessica Van Ziffle Nancy M. Joseph Courtney Onodera Eric Talevich James P. Grenert Iman H. Hewedi Matija Snuderl Daniel J. Brat Bette K. Kleinschmidt-DeMasters Fausto J. Rodriguez David N. Louis William H. Yong M. Beatriz Lopes Marc K. Rosenblum Nicholas Butowski Tarik Tihan Andrew W. Bollen Joanna J. Phillips Arun P. Wiita Iwei Yeh Matthew P. Jacobson Boris C. Bastian Arie Perry David A. Solomon |
| author_sort |
Benjamin Goode |
| title |
A recurrent kinase domain mutation in PRKCA defines chordoid glioma of the third ventricle |
| title_short |
A recurrent kinase domain mutation in PRKCA defines chordoid glioma of the third ventricle |
| title_full |
A recurrent kinase domain mutation in PRKCA defines chordoid glioma of the third ventricle |
| title_fullStr |
A recurrent kinase domain mutation in PRKCA defines chordoid glioma of the third ventricle |
| title_full_unstemmed |
A recurrent kinase domain mutation in PRKCA defines chordoid glioma of the third ventricle |
| title_sort |
recurrent kinase domain mutation in prkca defines chordoid glioma of the third ventricle |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/8ff58d0463294f3b9772e2541cb2ebc5 |
| work_keys_str_mv |
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