Liver abnormalities in pulmonary arterial hypertension

Pulmonary arterial hypertension (PAH) is a cardiopulmonary disease with high mortality. In recent years, it has been recognized that PAH is a multi-organ system disease, involving the systemic circulation, kidneys, skeletal muscles, and the central nervous system, among others. Right heart failure p...

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Autores principales:	Nils P. Nickel, Gian M. Galura, Marc J. Zuckerman, M. Nawar Hakim, Haider Alkhateeb, Debabrata Mukherjee, Eric D. Austin, Gustavo A. Heresi
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Diseases of the circulatory (Cardiovascular) system RC666-701 Diseases of the respiratory system RC705-779
Acceso en línea:	https://doaj.org/article/8ff5dbda5de746daa6ac14ecc0538b4f
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spelling	oai:doaj.org-article:8ff5dbda5de746daa6ac14ecc0538b4f2021-11-15T14:03:19ZLiver abnormalities in pulmonary arterial hypertension2045-894010.1177/20458940211054304https://doaj.org/article/8ff5dbda5de746daa6ac14ecc0538b4f2021-10-01T00:00:00Zhttps://doi.org/10.1177/20458940211054304https://doaj.org/toc/2045-8940Pulmonary arterial hypertension (PAH) is a cardiopulmonary disease with high mortality. In recent years, it has been recognized that PAH is a multi-organ system disease, involving the systemic circulation, kidneys, skeletal muscles, and the central nervous system, among others. Right heart failure produces congestive hepatopathy, a disease state that has direct consequences on liver biochemistry, histology, and systemic glucose and lipid metabolism. This article aims to summarize the consequences of congestive hepatopathy with an emphasis on liver biochemistry, histology, and PAH-targeted therapy. Furthermore, PAH-specific changes in glucose and lipid metabolism will be discussed.Nils P. NickelGian M. GaluraMarc J. ZuckermanM. Nawar HakimHaider AlkhateebDebabrata MukherjeeEric D. AustinGustavo A. HeresiSAGE PublishingarticleDiseases of the circulatory (Cardiovascular) systemRC666-701Diseases of the respiratory systemRC705-779ENPulmonary Circulation, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the circulatory (Cardiovascular) system RC666-701 Diseases of the respiratory system RC705-779
spellingShingle	Diseases of the circulatory (Cardiovascular) system RC666-701 Diseases of the respiratory system RC705-779 Nils P. Nickel Gian M. Galura Marc J. Zuckerman M. Nawar Hakim Haider Alkhateeb Debabrata Mukherjee Eric D. Austin Gustavo A. Heresi Liver abnormalities in pulmonary arterial hypertension
description	Pulmonary arterial hypertension (PAH) is a cardiopulmonary disease with high mortality. In recent years, it has been recognized that PAH is a multi-organ system disease, involving the systemic circulation, kidneys, skeletal muscles, and the central nervous system, among others. Right heart failure produces congestive hepatopathy, a disease state that has direct consequences on liver biochemistry, histology, and systemic glucose and lipid metabolism. This article aims to summarize the consequences of congestive hepatopathy with an emphasis on liver biochemistry, histology, and PAH-targeted therapy. Furthermore, PAH-specific changes in glucose and lipid metabolism will be discussed.
format	article
author	Nils P. Nickel Gian M. Galura Marc J. Zuckerman M. Nawar Hakim Haider Alkhateeb Debabrata Mukherjee Eric D. Austin Gustavo A. Heresi
author_facet	Nils P. Nickel Gian M. Galura Marc J. Zuckerman M. Nawar Hakim Haider Alkhateeb Debabrata Mukherjee Eric D. Austin Gustavo A. Heresi
author_sort	Nils P. Nickel
title	Liver abnormalities in pulmonary arterial hypertension
title_short	Liver abnormalities in pulmonary arterial hypertension
title_full	Liver abnormalities in pulmonary arterial hypertension
title_fullStr	Liver abnormalities in pulmonary arterial hypertension
title_full_unstemmed	Liver abnormalities in pulmonary arterial hypertension
title_sort	liver abnormalities in pulmonary arterial hypertension
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/8ff5dbda5de746daa6ac14ecc0538b4f
work_keys_str_mv	AT nilspnickel liverabnormalitiesinpulmonaryarterialhypertension AT gianmgalura liverabnormalitiesinpulmonaryarterialhypertension AT marcjzuckerman liverabnormalitiesinpulmonaryarterialhypertension AT mnawarhakim liverabnormalitiesinpulmonaryarterialhypertension AT haideralkhateeb liverabnormalitiesinpulmonaryarterialhypertension AT debabratamukherjee liverabnormalitiesinpulmonaryarterialhypertension AT ericdaustin liverabnormalitiesinpulmonaryarterialhypertension AT gustavoaheresi liverabnormalitiesinpulmonaryarterialhypertension
_version_	1718428389468012544

Liver abnormalities in pulmonary arterial hypertension

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