Mood disorders in the elderly: prevalence, functional impact, and management challenges

Leandro da Costa Lane Valiengo,1 Florindo Stella,1,2 Orestes Vicente Forlenza1 1Laboratory of Neuroscience (LIM-27), Department and Institute of Psychiatry, Faculty of Medicine, University of São Paulo, Sao Paulo, 2Biosciences Institute, Universidade Estadual Paulista, Rio Claro, Brazil...

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Autores principales:	Valiengo LCL, Stella F, Forlenza OV
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	depression bipolar disorder mood disorder elderly old-age older adults Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/8ff6f1fed505470398797669bab4cf10
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spelling	oai:doaj.org-article:8ff6f1fed505470398797669bab4cf102021-12-02T01:52:17ZMood disorders in the elderly: prevalence, functional impact, and management challenges1178-2021https://doaj.org/article/8ff6f1fed505470398797669bab4cf102016-08-01T00:00:00Zhttps://www.dovepress.com/mood-disorders--in-the-elderly-prevalence-functional-impact-and-manage-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Leandro da Costa Lane Valiengo,1 Florindo Stella,1,2 Orestes Vicente Forlenza1 1Laboratory of Neuroscience (LIM-27), Department and Institute of Psychiatry, Faculty of Medicine, University of São Paulo, Sao Paulo, 2Biosciences Institute, Universidade Estadual Paulista, Rio Claro, Brazil Abstract: Despite the lower prevalence of severe mood disorders in the elderly as compared to younger adults, late-life depression and bipolar disorder (BD) are more strongly associated with negative outcomes related to the presence of medical comorbidities, cognitive deficits, and increased suicide risk and overall mortality. The mechanisms that contribute to these associations are probably multifactorial, involving pathological factors related directly and indirectly to the disease itself, ranging from biological to psychosocial factors. Most of the accumulated knowledge on the nature of these associations derives from naturalistic and observational studies, and controlled data are still scarce. Nonetheless, there has clearly been a recent growth of the scientific interest on late-life BD and geriatric depression. In the present study, we review the most relevant studies on prevalence, clinical presentation, and cognitive/functional impact of mood disorders in elderly. Several clinical–epidemiological studies were dedicated to the study of the prevalence of mood disorders in old age in distinct settings; however, fewer studies investigated the underlying neurobiological findings and treatment specificities in late-life depression and BD. In the present study, we further discuss the implications of these findings on the management of mood disorders in older adults. Keywords: depression, bipolar disorder, psychogeriatric, geriatric, old age, older adultsValiengo LCLStella FForlenza OVDove Medical Pressarticledepressionbipolar disordermood disorderelderlyold-ageolder adultsNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 12, Pp 2105-2114 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	depression bipolar disorder mood disorder elderly old-age older adults Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	depression bipolar disorder mood disorder elderly old-age older adults Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Valiengo LCL Stella F Forlenza OV Mood disorders in the elderly: prevalence, functional impact, and management challenges
description	Leandro da Costa Lane Valiengo,1 Florindo Stella,1,2 Orestes Vicente Forlenza1 1Laboratory of Neuroscience (LIM-27), Department and Institute of Psychiatry, Faculty of Medicine, University of São Paulo, Sao Paulo, 2Biosciences Institute, Universidade Estadual Paulista, Rio Claro, Brazil Abstract: Despite the lower prevalence of severe mood disorders in the elderly as compared to younger adults, late-life depression and bipolar disorder (BD) are more strongly associated with negative outcomes related to the presence of medical comorbidities, cognitive deficits, and increased suicide risk and overall mortality. The mechanisms that contribute to these associations are probably multifactorial, involving pathological factors related directly and indirectly to the disease itself, ranging from biological to psychosocial factors. Most of the accumulated knowledge on the nature of these associations derives from naturalistic and observational studies, and controlled data are still scarce. Nonetheless, there has clearly been a recent growth of the scientific interest on late-life BD and geriatric depression. In the present study, we review the most relevant studies on prevalence, clinical presentation, and cognitive/functional impact of mood disorders in elderly. Several clinical–epidemiological studies were dedicated to the study of the prevalence of mood disorders in old age in distinct settings; however, fewer studies investigated the underlying neurobiological findings and treatment specificities in late-life depression and BD. In the present study, we further discuss the implications of these findings on the management of mood disorders in older adults. Keywords: depression, bipolar disorder, psychogeriatric, geriatric, old age, older adults
format	article
author	Valiengo LCL Stella F Forlenza OV
author_facet	Valiengo LCL Stella F Forlenza OV
author_sort	Valiengo LCL
title	Mood disorders in the elderly: prevalence, functional impact, and management challenges
title_short	Mood disorders in the elderly: prevalence, functional impact, and management challenges
title_full	Mood disorders in the elderly: prevalence, functional impact, and management challenges
title_fullStr	Mood disorders in the elderly: prevalence, functional impact, and management challenges
title_full_unstemmed	Mood disorders in the elderly: prevalence, functional impact, and management challenges
title_sort	mood disorders in the elderly: prevalence, functional impact, and management challenges
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/8ff6f1fed505470398797669bab4cf10
work_keys_str_mv	AT valiengolcl mooddisordersintheelderlyprevalencefunctionalimpactandmanagementchallenges AT stellaf mooddisordersintheelderlyprevalencefunctionalimpactandmanagementchallenges AT forlenzaov mooddisordersintheelderlyprevalencefunctionalimpactandmanagementchallenges
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Mood disorders in the elderly: prevalence, functional impact, and management challenges

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