Src-transformed cells hijack mitosis to extrude from the epithelium

Src-transformed cells hijack mitosis to extrude from the epithelium

Potentially cancerous cells undergo live apical extrusion from normal monolayers and vSrc expression induces this in zebrafish epithelia. Here, the authors show that vSrc coordinates cytokinetic ring formation, cell cycle progression, junctional integrity, cell survival and apicobasal polarity to in...

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Autores principales: Katarzyna A. Anton, Mihoko Kajita, Rika Narumi, Yasuyuki Fujita, Masazumi Tada
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/8ff80693d50442bea784cc1754aca29d
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spelling oai:doaj.org-article:8ff80693d50442bea784cc1754aca29d2021-12-02T16:50:08ZSrc-transformed cells hijack mitosis to extrude from the epithelium10.1038/s41467-018-07163-42041-1723https://doaj.org/article/8ff80693d50442bea784cc1754aca29d2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07163-4https://doaj.org/toc/2041-1723Potentially cancerous cells undergo live apical extrusion from normal monolayers and vSrc expression induces this in zebrafish epithelia. Here, the authors show that vSrc coordinates cytokinetic ring formation, cell cycle progression, junctional integrity, cell survival and apicobasal polarity to induce extrusion of transformed cells.Katarzyna A. AntonMihoko KajitaRika NarumiYasuyuki FujitaMasazumi TadaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Katarzyna A. Anton
Mihoko Kajita
Rika Narumi
Yasuyuki Fujita
Masazumi Tada
Src-transformed cells hijack mitosis to extrude from the epithelium
description Potentially cancerous cells undergo live apical extrusion from normal monolayers and vSrc expression induces this in zebrafish epithelia. Here, the authors show that vSrc coordinates cytokinetic ring formation, cell cycle progression, junctional integrity, cell survival and apicobasal polarity to induce extrusion of transformed cells.
format article
author Katarzyna A. Anton
Mihoko Kajita
Rika Narumi
Yasuyuki Fujita
Masazumi Tada
author_facet Katarzyna A. Anton
Mihoko Kajita
Rika Narumi
Yasuyuki Fujita
Masazumi Tada
author_sort Katarzyna A. Anton
title Src-transformed cells hijack mitosis to extrude from the epithelium
title_short Src-transformed cells hijack mitosis to extrude from the epithelium
title_full Src-transformed cells hijack mitosis to extrude from the epithelium
title_fullStr Src-transformed cells hijack mitosis to extrude from the epithelium
title_full_unstemmed Src-transformed cells hijack mitosis to extrude from the epithelium
title_sort src-transformed cells hijack mitosis to extrude from the epithelium
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/8ff80693d50442bea784cc1754aca29d
work_keys_str_mv AT katarzynaaanton srctransformedcellshijackmitosistoextrudefromtheepithelium
AT mihokokajita srctransformedcellshijackmitosistoextrudefromtheepithelium
AT rikanarumi srctransformedcellshijackmitosistoextrudefromtheepithelium
AT yasuyukifujita srctransformedcellshijackmitosistoextrudefromtheepithelium
AT masazumitada srctransformedcellshijackmitosistoextrudefromtheepithelium
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