Collective motion of cells crawling on a substrate: roles of cell shape and contact inhibition

Abstract Contact inhibition plays a crucial role in cell motility, wound healing, and tumour formation. By mimicking the mechanical motion of cells crawling on a substrate, we constructed a minimal model of migrating cells that naturally gives rise to contact inhibition of locomotion (CIL). The mode...

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Autores principales:	Simon K. Schnyder, John J. Molina, Yuki Tanaka, Ryoichi Yamamoto
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8ffa6c5abc744bff8c0d4d2d6fca95dc
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spelling	oai:doaj.org-article:8ffa6c5abc744bff8c0d4d2d6fca95dc2021-12-02T12:32:33ZCollective motion of cells crawling on a substrate: roles of cell shape and contact inhibition10.1038/s41598-017-05321-02045-2322https://doaj.org/article/8ffa6c5abc744bff8c0d4d2d6fca95dc2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05321-0https://doaj.org/toc/2045-2322Abstract Contact inhibition plays a crucial role in cell motility, wound healing, and tumour formation. By mimicking the mechanical motion of cells crawling on a substrate, we constructed a minimal model of migrating cells that naturally gives rise to contact inhibition of locomotion (CIL). The model cell consists of two disks, a front disk (a pseudopod) and a back disk (cell body), which are connected by a finite extensible spring. Despite the simplicity of the model, the collective behaviour of the cells is highly non-trivial and depends on both the shape of the cells and whether CIL is enabled. Cells with a small front disk (i.e., a narrow pseudopod) form immobile colonies. In contrast, cells with a large front disk (e.g., a lamellipodium) exhibit coherent migration without any explicit alignment mechanism in the model. This result suggests that crawling cells often exhibit broad fronts because this helps facilitate alignment. After increasing the density, the cells develop density waves that propagate against the direction of cell migration and finally stop at higher densities.Simon K. SchnyderJohn J. MolinaYuki TanakaRyoichi YamamotoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Simon K. Schnyder John J. Molina Yuki Tanaka Ryoichi Yamamoto Collective motion of cells crawling on a substrate: roles of cell shape and contact inhibition
description	Abstract Contact inhibition plays a crucial role in cell motility, wound healing, and tumour formation. By mimicking the mechanical motion of cells crawling on a substrate, we constructed a minimal model of migrating cells that naturally gives rise to contact inhibition of locomotion (CIL). The model cell consists of two disks, a front disk (a pseudopod) and a back disk (cell body), which are connected by a finite extensible spring. Despite the simplicity of the model, the collective behaviour of the cells is highly non-trivial and depends on both the shape of the cells and whether CIL is enabled. Cells with a small front disk (i.e., a narrow pseudopod) form immobile colonies. In contrast, cells with a large front disk (e.g., a lamellipodium) exhibit coherent migration without any explicit alignment mechanism in the model. This result suggests that crawling cells often exhibit broad fronts because this helps facilitate alignment. After increasing the density, the cells develop density waves that propagate against the direction of cell migration and finally stop at higher densities.
format	article
author	Simon K. Schnyder John J. Molina Yuki Tanaka Ryoichi Yamamoto
author_facet	Simon K. Schnyder John J. Molina Yuki Tanaka Ryoichi Yamamoto
author_sort	Simon K. Schnyder
title	Collective motion of cells crawling on a substrate: roles of cell shape and contact inhibition
title_short	Collective motion of cells crawling on a substrate: roles of cell shape and contact inhibition
title_full	Collective motion of cells crawling on a substrate: roles of cell shape and contact inhibition
title_fullStr	Collective motion of cells crawling on a substrate: roles of cell shape and contact inhibition
title_full_unstemmed	Collective motion of cells crawling on a substrate: roles of cell shape and contact inhibition
title_sort	collective motion of cells crawling on a substrate: roles of cell shape and contact inhibition
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/8ffa6c5abc744bff8c0d4d2d6fca95dc
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_version_	1718394047897272320

Collective motion of cells crawling on a substrate: roles of cell shape and contact inhibition

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