Altered neural oscillations during complex sequential movements in patients with Parkinson’s disease

The sequelae of Parkinson’s disease (PD) includes both motor- and cognitive-related symptoms. Although traditionally considered a subcortical disease, there is increasing evidence that PD has a major impact on cortical function as well. Prior studies have reported alterations in cortical neural func...

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Autores principales:	Marie C. McCusker, Alex I. Wiesman, Rachel K. Spooner, Pamela M. Santamaria, Jennifer McKune, Elizabeth Heinrichs-Graham, Tony W. Wilson
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Motor complexity Alpha oscillations Magnetoencephalography Parietal cortex Computer applications to medicine. Medical informatics R858-859.7 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/8ffaac5d26584cb2b949c7d344e85223
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id	oai:doaj.org-article:8ffaac5d26584cb2b949c7d344e85223
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spelling	oai:doaj.org-article:8ffaac5d26584cb2b949c7d344e852232021-12-02T05:01:30ZAltered neural oscillations during complex sequential movements in patients with Parkinson’s disease2213-158210.1016/j.nicl.2021.102892https://doaj.org/article/8ffaac5d26584cb2b949c7d344e852232021-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2213158221003363https://doaj.org/toc/2213-1582The sequelae of Parkinson’s disease (PD) includes both motor- and cognitive-related symptoms. Although traditionally considered a subcortical disease, there is increasing evidence that PD has a major impact on cortical function as well. Prior studies have reported alterations in cortical neural function in patients with PD during movement, but to date such studies have not examined whether the complexity of multicomponent movements modulate these alterations. In this study, 23 patients with PD (medication “off” state) and 27 matched healthy controls performed simple and complex finger tapping sequences during magnetoencephalography (MEG), and the resulting MEG data were imaged to identify the cortical oscillatory dynamics serving motor performance. The patients with PD were significantly slower than controls at executing the sequences overall, and both groups took longer to complete the complex sequences than the simple. In terms of neural differences, patients also exhibited weaker beta complexity-related effects in the right medial frontal gyrus and weaker complexity-related alpha activity in the right posterior and inferior parietal lobules, suggesting impaired motor sequence execution. Characterizing the cortical pathophysiology of PD could inform current and future therapeutic interventions that address both motor and cognitive symptoms.Marie C. McCuskerAlex I. WiesmanRachel K. SpoonerPamela M. SantamariaJennifer McKuneElizabeth Heinrichs-GrahamTony W. WilsonElsevierarticleMotor complexityAlpha oscillationsMagnetoencephalographyParietal cortexComputer applications to medicine. Medical informaticsR858-859.7Neurology. Diseases of the nervous systemRC346-429ENNeuroImage: Clinical, Vol 32, Iss , Pp 102892- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Motor complexity Alpha oscillations Magnetoencephalography Parietal cortex Computer applications to medicine. Medical informatics R858-859.7 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Motor complexity Alpha oscillations Magnetoencephalography Parietal cortex Computer applications to medicine. Medical informatics R858-859.7 Neurology. Diseases of the nervous system RC346-429 Marie C. McCusker Alex I. Wiesman Rachel K. Spooner Pamela M. Santamaria Jennifer McKune Elizabeth Heinrichs-Graham Tony W. Wilson Altered neural oscillations during complex sequential movements in patients with Parkinson’s disease
description	The sequelae of Parkinson’s disease (PD) includes both motor- and cognitive-related symptoms. Although traditionally considered a subcortical disease, there is increasing evidence that PD has a major impact on cortical function as well. Prior studies have reported alterations in cortical neural function in patients with PD during movement, but to date such studies have not examined whether the complexity of multicomponent movements modulate these alterations. In this study, 23 patients with PD (medication “off” state) and 27 matched healthy controls performed simple and complex finger tapping sequences during magnetoencephalography (MEG), and the resulting MEG data were imaged to identify the cortical oscillatory dynamics serving motor performance. The patients with PD were significantly slower than controls at executing the sequences overall, and both groups took longer to complete the complex sequences than the simple. In terms of neural differences, patients also exhibited weaker beta complexity-related effects in the right medial frontal gyrus and weaker complexity-related alpha activity in the right posterior and inferior parietal lobules, suggesting impaired motor sequence execution. Characterizing the cortical pathophysiology of PD could inform current and future therapeutic interventions that address both motor and cognitive symptoms.
format	article
author	Marie C. McCusker Alex I. Wiesman Rachel K. Spooner Pamela M. Santamaria Jennifer McKune Elizabeth Heinrichs-Graham Tony W. Wilson
author_facet	Marie C. McCusker Alex I. Wiesman Rachel K. Spooner Pamela M. Santamaria Jennifer McKune Elizabeth Heinrichs-Graham Tony W. Wilson
author_sort	Marie C. McCusker
title	Altered neural oscillations during complex sequential movements in patients with Parkinson’s disease
title_short	Altered neural oscillations during complex sequential movements in patients with Parkinson’s disease
title_full	Altered neural oscillations during complex sequential movements in patients with Parkinson’s disease
title_fullStr	Altered neural oscillations during complex sequential movements in patients with Parkinson’s disease
title_full_unstemmed	Altered neural oscillations during complex sequential movements in patients with Parkinson’s disease
title_sort	altered neural oscillations during complex sequential movements in patients with parkinson’s disease
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/8ffaac5d26584cb2b949c7d344e85223
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Altered neural oscillations during complex sequential movements in patients with Parkinson’s disease

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