c-Met modulates RPE migratory response to laser-induced retinal injury.

Retinal laser injuries are often associated with aberrant migration of the retinal pigment epithelium (RPE), which can cause expansion of the scar beyond the confines of the original laser burn. In this study, we devised a novel method of laser-induced injury to the RPE layer in mouse models and beg...

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Autores principales:	Masataka Kasaoka, Jie Ma, Kameran Lashkari
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8ffe9576b09443d587c086d34bca63cf
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spelling	oai:doaj.org-article:8ffe9576b09443d587c086d34bca63cf2021-11-18T07:12:31Zc-Met modulates RPE migratory response to laser-induced retinal injury.1932-620310.1371/journal.pone.0040771https://doaj.org/article/8ffe9576b09443d587c086d34bca63cf2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22808260/?tool=EBIhttps://doaj.org/toc/1932-6203Retinal laser injuries are often associated with aberrant migration of the retinal pigment epithelium (RPE), which can cause expansion of the scar beyond the confines of the original laser burn. In this study, we devised a novel method of laser-induced injury to the RPE layer in mouse models and began to dissect the mechanisms associated with pathogenesis and progression of laser-induced RPE injury. We have hypothesized that the proto-oncogene receptor, c-Met, is intimately involved with migration of RPE cells, and may be an early responder to injury. Using transgenic mouse models, we show that constitutive activation of c-Met induces more robust RPE migration into the outer retina of laser-injured eyes, while abrogation of the receptor using a cre-lox method reduces these responses. We also demonstrate that retinal laser injury increases expression of both HGF and c-Met, and activation of c-Met after injury is correlated with RPE cell migration. RPE migration may be responsible for clinically significant anatomic changes observed after laser injury. Abrogation of c-Met activity may be a therapeutic target to minimize retinal damage from aberrant RPE cell migration.Masataka KasaokaJie MaKameran LashkariPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 7, p e40771 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Masataka Kasaoka Jie Ma Kameran Lashkari c-Met modulates RPE migratory response to laser-induced retinal injury.
description	Retinal laser injuries are often associated with aberrant migration of the retinal pigment epithelium (RPE), which can cause expansion of the scar beyond the confines of the original laser burn. In this study, we devised a novel method of laser-induced injury to the RPE layer in mouse models and began to dissect the mechanisms associated with pathogenesis and progression of laser-induced RPE injury. We have hypothesized that the proto-oncogene receptor, c-Met, is intimately involved with migration of RPE cells, and may be an early responder to injury. Using transgenic mouse models, we show that constitutive activation of c-Met induces more robust RPE migration into the outer retina of laser-injured eyes, while abrogation of the receptor using a cre-lox method reduces these responses. We also demonstrate that retinal laser injury increases expression of both HGF and c-Met, and activation of c-Met after injury is correlated with RPE cell migration. RPE migration may be responsible for clinically significant anatomic changes observed after laser injury. Abrogation of c-Met activity may be a therapeutic target to minimize retinal damage from aberrant RPE cell migration.
format	article
author	Masataka Kasaoka Jie Ma Kameran Lashkari
author_facet	Masataka Kasaoka Jie Ma Kameran Lashkari
author_sort	Masataka Kasaoka
title	c-Met modulates RPE migratory response to laser-induced retinal injury.
title_short	c-Met modulates RPE migratory response to laser-induced retinal injury.
title_full	c-Met modulates RPE migratory response to laser-induced retinal injury.
title_fullStr	c-Met modulates RPE migratory response to laser-induced retinal injury.
title_full_unstemmed	c-Met modulates RPE migratory response to laser-induced retinal injury.
title_sort	c-met modulates rpe migratory response to laser-induced retinal injury.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/8ffe9576b09443d587c086d34bca63cf
work_keys_str_mv	AT masatakakasaoka cmetmodulatesrpemigratoryresponsetolaserinducedretinalinjury AT jiema cmetmodulatesrpemigratoryresponsetolaserinducedretinalinjury AT kameranlashkari cmetmodulatesrpemigratoryresponsetolaserinducedretinalinjury
_version_	1718423803254538240

c-Met modulates RPE migratory response to laser-induced retinal injury.

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