C3 complement inhibition prevents antibody-mediated rejection and prolongs renal allograft survival in sensitized non-human primates

Donor-specific antibodies in sensitized recipients may cause kidney transplant rejection. Here the authors show that complement component C3 inhibition prolongs graft survival by inhibiting T and B cell proliferation/activation and hence tissue injury, despite antibody levels remaining unaffected.

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Autores principales:	Robin Schmitz, Zachary W. Fitch, Paul M. Schroder, Ashley Y. Choi, Miriam Manook, Janghoon Yoon, Mingqing Song, John S. Yi, Sanjay Khandelwal, Gowthami M. Arepally, Alton B. Farris, Edimara S. Reis, John D. Lambris, Jean Kwun, Stuart J. Knechtle
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9003312b88304e17b0bd7ab46a8e6ace
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spelling	oai:doaj.org-article:9003312b88304e17b0bd7ab46a8e6ace2021-12-02T15:15:41ZC3 complement inhibition prevents antibody-mediated rejection and prolongs renal allograft survival in sensitized non-human primates10.1038/s41467-021-25745-72041-1723https://doaj.org/article/9003312b88304e17b0bd7ab46a8e6ace2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25745-7https://doaj.org/toc/2041-1723Donor-specific antibodies in sensitized recipients may cause kidney transplant rejection. Here the authors show that complement component C3 inhibition prolongs graft survival by inhibiting T and B cell proliferation/activation and hence tissue injury, despite antibody levels remaining unaffected.Robin SchmitzZachary W. FitchPaul M. SchroderAshley Y. ChoiMiriam ManookJanghoon YoonMingqing SongJohn S. YiSanjay KhandelwalGowthami M. ArepallyAlton B. FarrisEdimara S. ReisJohn D. LambrisJean KwunStuart J. KnechtleNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Robin Schmitz Zachary W. Fitch Paul M. Schroder Ashley Y. Choi Miriam Manook Janghoon Yoon Mingqing Song John S. Yi Sanjay Khandelwal Gowthami M. Arepally Alton B. Farris Edimara S. Reis John D. Lambris Jean Kwun Stuart J. Knechtle C3 complement inhibition prevents antibody-mediated rejection and prolongs renal allograft survival in sensitized non-human primates
description	Donor-specific antibodies in sensitized recipients may cause kidney transplant rejection. Here the authors show that complement component C3 inhibition prolongs graft survival by inhibiting T and B cell proliferation/activation and hence tissue injury, despite antibody levels remaining unaffected.
format	article
author	Robin Schmitz Zachary W. Fitch Paul M. Schroder Ashley Y. Choi Miriam Manook Janghoon Yoon Mingqing Song John S. Yi Sanjay Khandelwal Gowthami M. Arepally Alton B. Farris Edimara S. Reis John D. Lambris Jean Kwun Stuart J. Knechtle
author_facet	Robin Schmitz Zachary W. Fitch Paul M. Schroder Ashley Y. Choi Miriam Manook Janghoon Yoon Mingqing Song John S. Yi Sanjay Khandelwal Gowthami M. Arepally Alton B. Farris Edimara S. Reis John D. Lambris Jean Kwun Stuart J. Knechtle
author_sort	Robin Schmitz
title	C3 complement inhibition prevents antibody-mediated rejection and prolongs renal allograft survival in sensitized non-human primates
title_short	C3 complement inhibition prevents antibody-mediated rejection and prolongs renal allograft survival in sensitized non-human primates
title_full	C3 complement inhibition prevents antibody-mediated rejection and prolongs renal allograft survival in sensitized non-human primates
title_fullStr	C3 complement inhibition prevents antibody-mediated rejection and prolongs renal allograft survival in sensitized non-human primates
title_full_unstemmed	C3 complement inhibition prevents antibody-mediated rejection and prolongs renal allograft survival in sensitized non-human primates
title_sort	c3 complement inhibition prevents antibody-mediated rejection and prolongs renal allograft survival in sensitized non-human primates
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9003312b88304e17b0bd7ab46a8e6ace
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C3 complement inhibition prevents antibody-mediated rejection and prolongs renal allograft survival in sensitized non-human primates

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