Association Between Stressful Life Events and Female Primary Sjogren’s Syndrome and Their Role in Disease Activity: A Retrospective Case–Control Study in China

Association Between Stressful Life Events and Female Primary Sjogren’s Syndrome and Their Role in Disease Activity: A Retrospective Case–Control Study in China

FanYan Meng,1 Shuang Ren,1 Yun Meng,1 Ning Tao,1,2 Jie Zhang1 1Traditional Chinese Medicine Department, The First Affiliated Hospital of China Medical University, Shenyang 110001, People’s Republic of China; 2Clinical Medicine of Traditional Chinese and Western Medicine, China Medical Univ...

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Autores principales: Meng FY, Ren S, Meng Y, Tao N, Zhang J
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2021
Materias:
primary sjogren's syndrome
stressful life events
retrospective case-control study
risk factors
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Acceso en línea:https://doaj.org/article/900684be82b54529867ddceaac33c6b5
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spelling oai:doaj.org-article:900684be82b54529867ddceaac33c6b52021-12-02T14:17:44ZAssociation Between Stressful Life Events and Female Primary Sjogren’s Syndrome and Their Role in Disease Activity: A Retrospective Case–Control Study in China1178-2021https://doaj.org/article/900684be82b54529867ddceaac33c6b52021-01-01T00:00:00Zhttps://www.dovepress.com/association-between-stressful-life-events-and-female-primary-sjogrenrs-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021FanYan Meng,1 Shuang Ren,1 Yun Meng,1 Ning Tao,1,2 Jie Zhang1 1Traditional Chinese Medicine Department, The First Affiliated Hospital of China Medical University, Shenyang 110001, People’s Republic of China; 2Clinical Medicine of Traditional Chinese and Western Medicine, China Medical University, Shenyang 110122, People’s Republic of ChinaCorrespondence: Jie ZhangTraditional Chinese Medicine Department, The First Affiliated Hospital of China Medical University, 155 Nanjing North Street, Heping District, Shenyang City, Liaoning Province, People’s Republic of ChinaTel +86-24-83283687Email zhangjie945@outlook.comPurpose: Previous evidence has shown that psychological stress can trigger the onset of autoimmune disease. This study aimed to investigate the prevalence of stressful life events preceding the onset of symptoms in female primary Sjogren’s syndrome (pSS) in China compared to controls and the possible associations of stressful life events with disease activity.Patients and Methods: This was a hospital-based retrospective case–control study. Sixty-seven consecutive female pSS patients and an equal number of age-matched (± 3 years) healthy controls were recruited for assessment using the related Stressful Life Events Scale. The pSS disease activity was measured by the EULAR Sjogren’s syndrome disease activity index. Data were analyzed by SPSS, version 23, using chi-square, univariate logistic regression, multiple logistic regression, and partial correlation.Results: A higher number of negative stressful life events before disease onset in pSS patients compared with healthy controls suggest that these play a role in increasing the risk of disease occurrence (OR = 2.59, 95% CI: 1.87– 3.58, p < 0.05). The number of positive life events did not differ between the two groups. Both the number and severity of the negative stressful life events were also significantly correlated with disease activity.Conclusion: Patients with pSS experienced more negative stressful life events in the year preceding the onset of symptoms than controls. Negative stressful life events before symptom onset may be risk factors for pSS and may affect pSS disease activity.Keywords: primary Sjogren’s syndrome, stressful life events, retrospective case-control study, risk factorsMeng FYRen SMeng YTao NZhang JDove Medical Pressarticleprimary sjogren's syndromestressful life eventsretrospective case-control studyrisk factorsNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 17, Pp 213-220 (2021)
institution DOAJ
collection DOAJ
language EN
topic primary sjogren's syndrome
stressful life events
retrospective case-control study
risk factors
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
spellingShingle primary sjogren's syndrome
stressful life events
retrospective case-control study
risk factors
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Meng FY
Ren S
Meng Y
Tao N
Zhang J
Association Between Stressful Life Events and Female Primary Sjogren’s Syndrome and Their Role in Disease Activity: A Retrospective Case–Control Study in China
description FanYan Meng,1 Shuang Ren,1 Yun Meng,1 Ning Tao,1,2 Jie Zhang1 1Traditional Chinese Medicine Department, The First Affiliated Hospital of China Medical University, Shenyang 110001, People’s Republic of China; 2Clinical Medicine of Traditional Chinese and Western Medicine, China Medical University, Shenyang 110122, People’s Republic of ChinaCorrespondence: Jie ZhangTraditional Chinese Medicine Department, The First Affiliated Hospital of China Medical University, 155 Nanjing North Street, Heping District, Shenyang City, Liaoning Province, People’s Republic of ChinaTel +86-24-83283687Email zhangjie945@outlook.comPurpose: Previous evidence has shown that psychological stress can trigger the onset of autoimmune disease. This study aimed to investigate the prevalence of stressful life events preceding the onset of symptoms in female primary Sjogren’s syndrome (pSS) in China compared to controls and the possible associations of stressful life events with disease activity.Patients and Methods: This was a hospital-based retrospective case–control study. Sixty-seven consecutive female pSS patients and an equal number of age-matched (± 3 years) healthy controls were recruited for assessment using the related Stressful Life Events Scale. The pSS disease activity was measured by the EULAR Sjogren’s syndrome disease activity index. Data were analyzed by SPSS, version 23, using chi-square, univariate logistic regression, multiple logistic regression, and partial correlation.Results: A higher number of negative stressful life events before disease onset in pSS patients compared with healthy controls suggest that these play a role in increasing the risk of disease occurrence (OR = 2.59, 95% CI: 1.87– 3.58, p < 0.05). The number of positive life events did not differ between the two groups. Both the number and severity of the negative stressful life events were also significantly correlated with disease activity.Conclusion: Patients with pSS experienced more negative stressful life events in the year preceding the onset of symptoms than controls. Negative stressful life events before symptom onset may be risk factors for pSS and may affect pSS disease activity.Keywords: primary Sjogren’s syndrome, stressful life events, retrospective case-control study, risk factors
format article
author Meng FY
Ren S
Meng Y
Tao N
Zhang J
author_facet Meng FY
Ren S
Meng Y
Tao N
Zhang J
author_sort Meng FY
title Association Between Stressful Life Events and Female Primary Sjogren’s Syndrome and Their Role in Disease Activity: A Retrospective Case–Control Study in China
title_short Association Between Stressful Life Events and Female Primary Sjogren’s Syndrome and Their Role in Disease Activity: A Retrospective Case–Control Study in China
title_full Association Between Stressful Life Events and Female Primary Sjogren’s Syndrome and Their Role in Disease Activity: A Retrospective Case–Control Study in China
title_fullStr Association Between Stressful Life Events and Female Primary Sjogren’s Syndrome and Their Role in Disease Activity: A Retrospective Case–Control Study in China
title_full_unstemmed Association Between Stressful Life Events and Female Primary Sjogren’s Syndrome and Their Role in Disease Activity: A Retrospective Case–Control Study in China
title_sort association between stressful life events and female primary sjogren’s syndrome and their role in disease activity: a retrospective case–control study in china
publisher Dove Medical Press
publishDate 2021
url https://doaj.org/article/900684be82b54529867ddceaac33c6b5
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