Clinical Value of SARS-CoV2 IgM and IgG Antibodies in Diagnosis of COVID-19 in Suspected Cases

Yangchun Feng Clinical Laboratory Center, The Third Hospital Affiliated to Xinjiang Medical University (Affiliated Cancer Hospital), Urumqi, 830011, People’s Republic of ChinaCorrespondence: Yangchun FengThird Hospital Affiliated to Xinjiang Medical University (Affiliated Cancer Hospital),...

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Autor principal:	Feng Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	covid-19 sars-cov-2 positive likelihood ratio posterior probability antibody test nucleic acid test clinical pathway Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/900b70e0ffa54013b7d1086a62c23ade
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spelling	oai:doaj.org-article:900b70e0ffa54013b7d1086a62c23ade2021-12-02T12:33:20ZClinical Value of SARS-CoV2 IgM and IgG Antibodies in Diagnosis of COVID-19 in Suspected Cases1178-7031https://doaj.org/article/900b70e0ffa54013b7d1086a62c23ade2020-12-01T00:00:00Zhttps://www.dovepress.com/clinical-value-of-sars-cov2-igm-and-igg-antibodies-in-diagnosis-of-cov-peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Yangchun Feng Clinical Laboratory Center, The Third Hospital Affiliated to Xinjiang Medical University (Affiliated Cancer Hospital), Urumqi, 830011, People’s Republic of ChinaCorrespondence: Yangchun FengThird Hospital Affiliated to Xinjiang Medical University (Affiliated Cancer Hospital), Urumqi 830011, People’s Republic of ChinaEmail paopao1987123@163.comObjective: To explore the clinical value of SARS-CoV2 IgM and IgG antibodies in the diagnosis of COVID-19 in suspected cases by likelihood ratio.Methods: By reinterpreting data from a previous study, the positive likelihood ratio of IgM and IgG antibodies in COVID-19 pneumonia diagnosis was calculated, and the posterior probability of IgM and IgG antibodies and their tandem detection was calculated finally.Results: The positive likelihood ratios of single IgM and IgG antibodies were 18.50 and 12.65, respectively, and the posterior probabilities were 90.18% and 86.26%, respectively. However, the posterior probability of the two antibody-tandem test was 99.15%, which could give clinicians more quantitative confidence in the diagnosis of COVID-19 in suspected cases. According to the results of this study, combining the advantages and disadvantages of nucleic acid testing and antibody detection, a feasible clinical path was found for clinicians to diagnose COVID-19 pneumonia from suspected cases.Conclusion: For suspected cases, IgM- and IgG-antibody tests should first be done at the same time. If all antibody tests are positive, COVID-19 pneumonia could be confirmed. If not, nucleic acid detection (once or more) should be carried out, and in extreme cases high-throughput viral genome sequencing is required.Keywords: COVID-19, SARS-CoV2, positive likelihood ratio, posterior probability, antibody test, nucleic acid test, clinical pathwayFeng YDove Medical Pressarticlecovid-19sars-cov-2positive likelihood ratioposterior probabilityantibody testnucleic acid testclinical pathwayPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 13, Pp 1089-1094 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	covid-19 sars-cov-2 positive likelihood ratio posterior probability antibody test nucleic acid test clinical pathway Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	covid-19 sars-cov-2 positive likelihood ratio posterior probability antibody test nucleic acid test clinical pathway Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Feng Y Clinical Value of SARS-CoV2 IgM and IgG Antibodies in Diagnosis of COVID-19 in Suspected Cases
description	Yangchun Feng Clinical Laboratory Center, The Third Hospital Affiliated to Xinjiang Medical University (Affiliated Cancer Hospital), Urumqi, 830011, People’s Republic of ChinaCorrespondence: Yangchun FengThird Hospital Affiliated to Xinjiang Medical University (Affiliated Cancer Hospital), Urumqi 830011, People’s Republic of ChinaEmail paopao1987123@163.comObjective: To explore the clinical value of SARS-CoV2 IgM and IgG antibodies in the diagnosis of COVID-19 in suspected cases by likelihood ratio.Methods: By reinterpreting data from a previous study, the positive likelihood ratio of IgM and IgG antibodies in COVID-19 pneumonia diagnosis was calculated, and the posterior probability of IgM and IgG antibodies and their tandem detection was calculated finally.Results: The positive likelihood ratios of single IgM and IgG antibodies were 18.50 and 12.65, respectively, and the posterior probabilities were 90.18% and 86.26%, respectively. However, the posterior probability of the two antibody-tandem test was 99.15%, which could give clinicians more quantitative confidence in the diagnosis of COVID-19 in suspected cases. According to the results of this study, combining the advantages and disadvantages of nucleic acid testing and antibody detection, a feasible clinical path was found for clinicians to diagnose COVID-19 pneumonia from suspected cases.Conclusion: For suspected cases, IgM- and IgG-antibody tests should first be done at the same time. If all antibody tests are positive, COVID-19 pneumonia could be confirmed. If not, nucleic acid detection (once or more) should be carried out, and in extreme cases high-throughput viral genome sequencing is required.Keywords: COVID-19, SARS-CoV2, positive likelihood ratio, posterior probability, antibody test, nucleic acid test, clinical pathway
format	article
author	Feng Y
author_facet	Feng Y
author_sort	Feng Y
title	Clinical Value of SARS-CoV2 IgM and IgG Antibodies in Diagnosis of COVID-19 in Suspected Cases
title_short	Clinical Value of SARS-CoV2 IgM and IgG Antibodies in Diagnosis of COVID-19 in Suspected Cases
title_full	Clinical Value of SARS-CoV2 IgM and IgG Antibodies in Diagnosis of COVID-19 in Suspected Cases
title_fullStr	Clinical Value of SARS-CoV2 IgM and IgG Antibodies in Diagnosis of COVID-19 in Suspected Cases
title_full_unstemmed	Clinical Value of SARS-CoV2 IgM and IgG Antibodies in Diagnosis of COVID-19 in Suspected Cases
title_sort	clinical value of sars-cov2 igm and igg antibodies in diagnosis of covid-19 in suspected cases
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/900b70e0ffa54013b7d1086a62c23ade
work_keys_str_mv	AT fengy clinicalvalueofsarscov2igmandiggantibodiesindiagnosisofcovid19insuspectedcases
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Clinical Value of SARS-CoV2 IgM and IgG Antibodies in Diagnosis of COVID-19 in Suspected Cases

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