A novel murine in vivo model for acute hereditary angioedema attacks

Abstract Hereditary Angioedema (HAE) is a rare genetic disease generally caused by deficiency or mutations in the C1-inhibitor gene, SERPING1, a member of the Serpin family. HAE results in acute attacks of edema, vasodilation, GI pain and hypotension. C1INH is a key inhibitor of enzymes controlling...

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Bibliographic Details
Main Authors: Sujata Bupp, Matthew Whittaker, Mari Lehtimaki, JuMe Park, Jessica Dement-Brown, Zhao-Hua Zhou, Steven Kozlowski
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
R
Q
Online Access:https://doaj.org/article/900e9df80c9a4d6880fc0a21fc2ae07d
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