Breeding of Cav2.3 deficient mice reveals Mendelian inheritance in contrast to complex inheritance in Cav3.2 null mutant breeding

Abstract High voltage-activated Cav2.3 R-type Ca2+ channels and low voltage-activated Cav3.2 T-type Ca2+ channels were reported to be involved in numerous physiological and pathophysiological processes. Many of these findings are based on studies in Cav2.3 and Cav3.2 deficient mice. Recently, it has...

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Autores principales:	Anna Papazoglou, Christina Henseler, Karl Broich, Johanna Daubner, Marco Weiergräber
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/90100b4c69d04baba5b661ce159d8e84
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spelling	oai:doaj.org-article:90100b4c69d04baba5b661ce159d8e842021-12-02T16:15:07ZBreeding of Cav2.3 deficient mice reveals Mendelian inheritance in contrast to complex inheritance in Cav3.2 null mutant breeding10.1038/s41598-021-93391-62045-2322https://doaj.org/article/90100b4c69d04baba5b661ce159d8e842021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93391-6https://doaj.org/toc/2045-2322Abstract High voltage-activated Cav2.3 R-type Ca2+ channels and low voltage-activated Cav3.2 T-type Ca2+ channels were reported to be involved in numerous physiological and pathophysiological processes. Many of these findings are based on studies in Cav2.3 and Cav3.2 deficient mice. Recently, it has been proposed that inbreeding of Cav2.3 and Cav3.2 deficient mice exhibits significant deviation from Mendelian inheritance and might be an indication for potential prenatal lethality in these lines. In our study, we analyzed 926 offspring from Cav3.2 breedings and 1142 offspring from Cav2.3 breedings. Our results demonstrate that breeding of Cav2.3 deficient mice shows typical Mendelian inheritance and that there is no indication of prenatal lethality. In contrast, Cav3.2 breeding exhibits a complex inheritance pattern. It might be speculated that the differences in inheritance, particularly for Cav2.3 breeding, are related to other factors, such as genetic specificities of the mutant lines, compensatory mechanisms and altered sperm activity.Anna PapazoglouChristina HenselerKarl BroichJohanna DaubnerMarco WeiergräberNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Anna Papazoglou Christina Henseler Karl Broich Johanna Daubner Marco Weiergräber Breeding of Cav2.3 deficient mice reveals Mendelian inheritance in contrast to complex inheritance in Cav3.2 null mutant breeding
description	Abstract High voltage-activated Cav2.3 R-type Ca2+ channels and low voltage-activated Cav3.2 T-type Ca2+ channels were reported to be involved in numerous physiological and pathophysiological processes. Many of these findings are based on studies in Cav2.3 and Cav3.2 deficient mice. Recently, it has been proposed that inbreeding of Cav2.3 and Cav3.2 deficient mice exhibits significant deviation from Mendelian inheritance and might be an indication for potential prenatal lethality in these lines. In our study, we analyzed 926 offspring from Cav3.2 breedings and 1142 offspring from Cav2.3 breedings. Our results demonstrate that breeding of Cav2.3 deficient mice shows typical Mendelian inheritance and that there is no indication of prenatal lethality. In contrast, Cav3.2 breeding exhibits a complex inheritance pattern. It might be speculated that the differences in inheritance, particularly for Cav2.3 breeding, are related to other factors, such as genetic specificities of the mutant lines, compensatory mechanisms and altered sperm activity.
format	article
author	Anna Papazoglou Christina Henseler Karl Broich Johanna Daubner Marco Weiergräber
author_facet	Anna Papazoglou Christina Henseler Karl Broich Johanna Daubner Marco Weiergräber
author_sort	Anna Papazoglou
title	Breeding of Cav2.3 deficient mice reveals Mendelian inheritance in contrast to complex inheritance in Cav3.2 null mutant breeding
title_short	Breeding of Cav2.3 deficient mice reveals Mendelian inheritance in contrast to complex inheritance in Cav3.2 null mutant breeding
title_full	Breeding of Cav2.3 deficient mice reveals Mendelian inheritance in contrast to complex inheritance in Cav3.2 null mutant breeding
title_fullStr	Breeding of Cav2.3 deficient mice reveals Mendelian inheritance in contrast to complex inheritance in Cav3.2 null mutant breeding
title_full_unstemmed	Breeding of Cav2.3 deficient mice reveals Mendelian inheritance in contrast to complex inheritance in Cav3.2 null mutant breeding
title_sort	breeding of cav2.3 deficient mice reveals mendelian inheritance in contrast to complex inheritance in cav3.2 null mutant breeding
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/90100b4c69d04baba5b661ce159d8e84
work_keys_str_mv	AT annapapazoglou breedingofcav23deficientmicerevealsmendelianinheritanceincontrasttocomplexinheritanceincav32nullmutantbreeding AT christinahenseler breedingofcav23deficientmicerevealsmendelianinheritanceincontrasttocomplexinheritanceincav32nullmutantbreeding AT karlbroich breedingofcav23deficientmicerevealsmendelianinheritanceincontrasttocomplexinheritanceincav32nullmutantbreeding AT johannadaubner breedingofcav23deficientmicerevealsmendelianinheritanceincontrasttocomplexinheritanceincav32nullmutantbreeding AT marcoweiergraber breedingofcav23deficientmicerevealsmendelianinheritanceincontrasttocomplexinheritanceincav32nullmutantbreeding
_version_	1718384304681123840

Breeding of Cav2.3 deficient mice reveals Mendelian inheritance in contrast to complex inheritance in Cav3.2 null mutant breeding

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