Endothelial Activation and Immune Thrombocytopenia: An Engagement Waiting for Consolidation

Immune thrombocytopenia (ITP) appears to be a heterogeneous disease. In some patients, autoimmunity may be associated with an inflammatory process, and in other patients, low platelets may interfere with other aspects of the coagulation system. Either may predispose to thrombosis or bleeding. Furthe...

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Autores principales:	Alaa Efat, Sabry Shoeib, Aida Nazir, Essam Abdelmohsen, Ashraf Dawod, Hanan M. Bedair, Walaa Elgheriany
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/9010aeff5a434db498d3b730d89abd20
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spelling	oai:doaj.org-article:9010aeff5a434db498d3b730d89abd202021-12-02T01:33:28ZEndothelial Activation and Immune Thrombocytopenia: An Engagement Waiting for Consolidation1938-272310.1177/10760296211054514https://doaj.org/article/9010aeff5a434db498d3b730d89abd202021-11-01T00:00:00Zhttps://doi.org/10.1177/10760296211054514https://doaj.org/toc/1938-2723Immune thrombocytopenia (ITP) appears to be a heterogeneous disease. In some patients, autoimmunity may be associated with an inflammatory process, and in other patients, low platelets may interfere with other aspects of the coagulation system. Either may predispose to thrombosis or bleeding. Further investigation of the interactions of platelets, with inflammatory cytokines and endothelial biomarkers, may help us to better understand the disease, and to recognize those patients at risk of bleeding, or conversely thrombosis. The aim of this work is to estimate von Willebrand factor (vWF) and vascular cellular adhesion molecule (V-CAM) serum levels in adult immune thrombocytopenic patients (ITP) and to decipher their possible clinical correlates. Eighty adults (≥ 18 years) were enrolled in the study; naive newly diagnosed 40 patients with primary ITP (according to the ASH 2019) and 40 sex and age-matched healthy controls, all groups are subjected for complete blood count (CBC), liver, and renal function tests, ESR, CRP, V-CAM, and VWF-Ag by enzyme-linked immunosorbent assay (ELISA). There was a highly statistically significant difference between case and control as regards to the mean level of VWF-Ag and V-CAM. vWF and V-CAM could serve as biomarkers for endothelial alterations and should be investigated as a predictor of thrombocytopenic bleeding and tailor patient management accordingly.Alaa EfatSabry ShoeibAida NazirEssam AbdelmohsenAshraf DawodHanan M. BedairWalaa ElgherianySAGE PublishingarticleDiseases of the circulatory (Cardiovascular) systemRC666-701ENClinical and Applied Thrombosis/Hemostasis, Vol 27 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	Diseases of the circulatory (Cardiovascular) system RC666-701 Alaa Efat Sabry Shoeib Aida Nazir Essam Abdelmohsen Ashraf Dawod Hanan M. Bedair Walaa Elgheriany Endothelial Activation and Immune Thrombocytopenia: An Engagement Waiting for Consolidation
description	Immune thrombocytopenia (ITP) appears to be a heterogeneous disease. In some patients, autoimmunity may be associated with an inflammatory process, and in other patients, low platelets may interfere with other aspects of the coagulation system. Either may predispose to thrombosis or bleeding. Further investigation of the interactions of platelets, with inflammatory cytokines and endothelial biomarkers, may help us to better understand the disease, and to recognize those patients at risk of bleeding, or conversely thrombosis. The aim of this work is to estimate von Willebrand factor (vWF) and vascular cellular adhesion molecule (V-CAM) serum levels in adult immune thrombocytopenic patients (ITP) and to decipher their possible clinical correlates. Eighty adults (≥ 18 years) were enrolled in the study; naive newly diagnosed 40 patients with primary ITP (according to the ASH 2019) and 40 sex and age-matched healthy controls, all groups are subjected for complete blood count (CBC), liver, and renal function tests, ESR, CRP, V-CAM, and VWF-Ag by enzyme-linked immunosorbent assay (ELISA). There was a highly statistically significant difference between case and control as regards to the mean level of VWF-Ag and V-CAM. vWF and V-CAM could serve as biomarkers for endothelial alterations and should be investigated as a predictor of thrombocytopenic bleeding and tailor patient management accordingly.
format	article
author	Alaa Efat Sabry Shoeib Aida Nazir Essam Abdelmohsen Ashraf Dawod Hanan M. Bedair Walaa Elgheriany
author_facet	Alaa Efat Sabry Shoeib Aida Nazir Essam Abdelmohsen Ashraf Dawod Hanan M. Bedair Walaa Elgheriany
author_sort	Alaa Efat
title	Endothelial Activation and Immune Thrombocytopenia: An Engagement Waiting for Consolidation
title_short	Endothelial Activation and Immune Thrombocytopenia: An Engagement Waiting for Consolidation
title_full	Endothelial Activation and Immune Thrombocytopenia: An Engagement Waiting for Consolidation
title_fullStr	Endothelial Activation and Immune Thrombocytopenia: An Engagement Waiting for Consolidation
title_full_unstemmed	Endothelial Activation and Immune Thrombocytopenia: An Engagement Waiting for Consolidation
title_sort	endothelial activation and immune thrombocytopenia: an engagement waiting for consolidation
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/9010aeff5a434db498d3b730d89abd20
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Endothelial Activation and Immune Thrombocytopenia: An Engagement Waiting for Consolidation

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