An ALE meta-analytical review of the neural correlates of abstract and concrete words

Abstract Several clinical studies have reported a double dissociation between abstract and concrete concepts, suggesting that they are processed by at least partly different networks in the brain. However, neuroimaging data seem not in line with neuropsychological reports. Using the ALE method, we r...

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Autores principales:	Madalina Bucur, Costanza Papagno
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/901433a55d6c4f52a3c3efdd634625ff
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spelling	oai:doaj.org-article:901433a55d6c4f52a3c3efdd634625ff2021-12-02T18:49:33ZAn ALE meta-analytical review of the neural correlates of abstract and concrete words10.1038/s41598-021-94506-92045-2322https://doaj.org/article/901433a55d6c4f52a3c3efdd634625ff2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94506-9https://doaj.org/toc/2045-2322Abstract Several clinical studies have reported a double dissociation between abstract and concrete concepts, suggesting that they are processed by at least partly different networks in the brain. However, neuroimaging data seem not in line with neuropsychological reports. Using the ALE method, we run a meta-analysis on 32 brain-activation imaging studies that considered only nouns and verbs. Five clusters were associated with concrete words, four clusters with abstract words. When only nouns were selected three left activation clusters were found to be associated with concrete stimuli and only one with abstract nouns (left IFG). These results confirm that concrete and abstract words processing involves at least partially segregated brain areas, the IFG being relevant for abstract nouns and verbs while more posterior temporoparietal-occipital regions seem to be crucial for processing concrete words, in contrast with the neuropsychological literature that suggests a temporal anterior involvement for concrete words. We investigated the possible reasons that produce different outcomes in neuroimaging and clinical studies.Madalina BucurCostanza PapagnoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-24 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Madalina Bucur Costanza Papagno An ALE meta-analytical review of the neural correlates of abstract and concrete words
description	Abstract Several clinical studies have reported a double dissociation between abstract and concrete concepts, suggesting that they are processed by at least partly different networks in the brain. However, neuroimaging data seem not in line with neuropsychological reports. Using the ALE method, we run a meta-analysis on 32 brain-activation imaging studies that considered only nouns and verbs. Five clusters were associated with concrete words, four clusters with abstract words. When only nouns were selected three left activation clusters were found to be associated with concrete stimuli and only one with abstract nouns (left IFG). These results confirm that concrete and abstract words processing involves at least partially segregated brain areas, the IFG being relevant for abstract nouns and verbs while more posterior temporoparietal-occipital regions seem to be crucial for processing concrete words, in contrast with the neuropsychological literature that suggests a temporal anterior involvement for concrete words. We investigated the possible reasons that produce different outcomes in neuroimaging and clinical studies.
format	article
author	Madalina Bucur Costanza Papagno
author_facet	Madalina Bucur Costanza Papagno
author_sort	Madalina Bucur
title	An ALE meta-analytical review of the neural correlates of abstract and concrete words
title_short	An ALE meta-analytical review of the neural correlates of abstract and concrete words
title_full	An ALE meta-analytical review of the neural correlates of abstract and concrete words
title_fullStr	An ALE meta-analytical review of the neural correlates of abstract and concrete words
title_full_unstemmed	An ALE meta-analytical review of the neural correlates of abstract and concrete words
title_sort	ale meta-analytical review of the neural correlates of abstract and concrete words
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/901433a55d6c4f52a3c3efdd634625ff
work_keys_str_mv	AT madalinabucur analemetaanalyticalreviewoftheneuralcorrelatesofabstractandconcretewords AT costanzapapagno analemetaanalyticalreviewoftheneuralcorrelatesofabstractandconcretewords AT madalinabucur alemetaanalyticalreviewoftheneuralcorrelatesofabstractandconcretewords AT costanzapapagno alemetaanalyticalreviewoftheneuralcorrelatesofabstractandconcretewords
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An ALE meta-analytical review of the neural correlates of abstract and concrete words

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