Influence of initial treatment modality on long-term control of chronic idiopathic urticaria.

<h4>Background</h4>Chronic idiopathic urticaria (CIU) is a common cutaneous disorder but the influence of initial treatment modality on long-term control is not known. The aim of this study was to evaluate clinical features, and the influence of initial treatment modality on long-term co...

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Autores principales: Sujeong Kim, Seunghee Baek, Bomi Shin, Sun-young Yoon, So Young Park, Taehoon Lee, Yoon Su Lee, Yun-Jeong Bae, Hyouk Soo Kwon, You Sook Cho, Hee-Bom Moon, Tae-Bum Kim
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
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Acceso en línea:https://doaj.org/article/901a25b168e847178eb6cb590ec07f83
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Sumario:<h4>Background</h4>Chronic idiopathic urticaria (CIU) is a common cutaneous disorder but the influence of initial treatment modality on long-term control is not known. The aim of this study was to evaluate clinical features, and the influence of initial treatment modality on long-term control.<h4>Methods and results</h4>641 CIU patients were enrolled from the allergy clinic in a tertiary referral hospital. Disease duration, aggravating factors and treatment modality at each visit were evaluated. Times required to reach a controlled state were analyzed according to initial treatment modality, using Kaplan-Meier survival curves, the Cox proportional-hazards model, and propensity scores. Female to male ratio was 1.7: 1; mean age at onset was 40.5 years. The most common aggravating factors were food (33.5%), stress (31.5%) and fatigue (21.6%). Most patients (82.2%) used H1-antihistamines alone as initial treatment while 17% used a combination treatment with oral corticosteroids. There was no significant difference in the time taken to reach a controlled state between patients treated with single vs multiple H1-antihistamines or between those who received H1-antihistamine monotherapy vs. a combination therapy with oral corticosteroids.<h4>Conclusion</h4>The time required to control CIU is not reduced by use of multiple H1-antihistamines or oral corticosteroids in the initial treatment.