An evolutionarily-conserved Wnt3/β-catenin/Sp5 feedback loop restricts head organizer activity in Hydra

Hydra regenerate various body parts on amputation by activation of the appropriate organiser, but how head formation is controlled is unclear. Here, the authors identify the transcription factor Sp5 as restricting head formation, by being activated by beta-catenin and then acting as a repressor of W...

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Autores principales:	Matthias C. Vogg, Leonardo Beccari, Laura Iglesias Ollé, Christine Rampon, Sophie Vriz, Chrystelle Perruchoud, Yvan Wenger, Brigitte Galliot
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/901a72a74dfc4da789e63b0de3b155d0
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id	oai:doaj.org-article:901a72a74dfc4da789e63b0de3b155d0
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spelling	oai:doaj.org-article:901a72a74dfc4da789e63b0de3b155d02021-12-02T16:51:00ZAn evolutionarily-conserved Wnt3/β-catenin/Sp5 feedback loop restricts head organizer activity in Hydra10.1038/s41467-018-08242-22041-1723https://doaj.org/article/901a72a74dfc4da789e63b0de3b155d02019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08242-2https://doaj.org/toc/2041-1723Hydra regenerate various body parts on amputation by activation of the appropriate organiser, but how head formation is controlled is unclear. Here, the authors identify the transcription factor Sp5 as restricting head formation, by being activated by beta-catenin and then acting as a repressor of Wnt3.Matthias C. VoggLeonardo BeccariLaura Iglesias OlléChristine RamponSophie VrizChrystelle PerruchoudYvan WengerBrigitte GalliotNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Matthias C. Vogg Leonardo Beccari Laura Iglesias Ollé Christine Rampon Sophie Vriz Chrystelle Perruchoud Yvan Wenger Brigitte Galliot An evolutionarily-conserved Wnt3/β-catenin/Sp5 feedback loop restricts head organizer activity in Hydra
description	Hydra regenerate various body parts on amputation by activation of the appropriate organiser, but how head formation is controlled is unclear. Here, the authors identify the transcription factor Sp5 as restricting head formation, by being activated by beta-catenin and then acting as a repressor of Wnt3.
format	article
author	Matthias C. Vogg Leonardo Beccari Laura Iglesias Ollé Christine Rampon Sophie Vriz Chrystelle Perruchoud Yvan Wenger Brigitte Galliot
author_facet	Matthias C. Vogg Leonardo Beccari Laura Iglesias Ollé Christine Rampon Sophie Vriz Chrystelle Perruchoud Yvan Wenger Brigitte Galliot
author_sort	Matthias C. Vogg
title	An evolutionarily-conserved Wnt3/β-catenin/Sp5 feedback loop restricts head organizer activity in Hydra
title_short	An evolutionarily-conserved Wnt3/β-catenin/Sp5 feedback loop restricts head organizer activity in Hydra
title_full	An evolutionarily-conserved Wnt3/β-catenin/Sp5 feedback loop restricts head organizer activity in Hydra
title_fullStr	An evolutionarily-conserved Wnt3/β-catenin/Sp5 feedback loop restricts head organizer activity in Hydra
title_full_unstemmed	An evolutionarily-conserved Wnt3/β-catenin/Sp5 feedback loop restricts head organizer activity in Hydra
title_sort	evolutionarily-conserved wnt3/β-catenin/sp5 feedback loop restricts head organizer activity in hydra
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/901a72a74dfc4da789e63b0de3b155d0
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An evolutionarily-conserved Wnt3/β-catenin/Sp5 feedback loop restricts head organizer activity in Hydra

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