Tight docking of membranes before fusion represents a metastable state with unique properties

Proteins need to overcome energy barriers to induce intermediate steps in membrane fusion. Using lipid vesicles in which progression to hemifusion is arrested, the authors show that the metastable intermediate is enhanced by divalent cations and is characterized by the absence of proteins and local...

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Autores principales:	Agata Witkowska, Leonard P. Heinz, Helmut Grubmüller, Reinhard Jahn
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/901cfa95a349420482eaf82f901e41d0
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spelling	oai:doaj.org-article:901cfa95a349420482eaf82f901e41d02021-12-02T17:40:35ZTight docking of membranes before fusion represents a metastable state with unique properties10.1038/s41467-021-23722-82041-1723https://doaj.org/article/901cfa95a349420482eaf82f901e41d02021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23722-8https://doaj.org/toc/2041-1723Proteins need to overcome energy barriers to induce intermediate steps in membrane fusion. Using lipid vesicles in which progression to hemifusion is arrested, the authors show that the metastable intermediate is enhanced by divalent cations and is characterized by the absence of proteins and local membrane thickening. Simulations reveal that thickening is induced by dehydration of the membrane surface.Agata WitkowskaLeonard P. HeinzHelmut GrubmüllerReinhard JahnNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Agata Witkowska Leonard P. Heinz Helmut Grubmüller Reinhard Jahn Tight docking of membranes before fusion represents a metastable state with unique properties
description	Proteins need to overcome energy barriers to induce intermediate steps in membrane fusion. Using lipid vesicles in which progression to hemifusion is arrested, the authors show that the metastable intermediate is enhanced by divalent cations and is characterized by the absence of proteins and local membrane thickening. Simulations reveal that thickening is induced by dehydration of the membrane surface.
format	article
author	Agata Witkowska Leonard P. Heinz Helmut Grubmüller Reinhard Jahn
author_facet	Agata Witkowska Leonard P. Heinz Helmut Grubmüller Reinhard Jahn
author_sort	Agata Witkowska
title	Tight docking of membranes before fusion represents a metastable state with unique properties
title_short	Tight docking of membranes before fusion represents a metastable state with unique properties
title_full	Tight docking of membranes before fusion represents a metastable state with unique properties
title_fullStr	Tight docking of membranes before fusion represents a metastable state with unique properties
title_full_unstemmed	Tight docking of membranes before fusion represents a metastable state with unique properties
title_sort	tight docking of membranes before fusion represents a metastable state with unique properties
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/901cfa95a349420482eaf82f901e41d0
work_keys_str_mv	AT agatawitkowska tightdockingofmembranesbeforefusionrepresentsametastablestatewithuniqueproperties AT leonardpheinz tightdockingofmembranesbeforefusionrepresentsametastablestatewithuniqueproperties AT helmutgrubmuller tightdockingofmembranesbeforefusionrepresentsametastablestatewithuniqueproperties AT reinhardjahn tightdockingofmembranesbeforefusionrepresentsametastablestatewithuniqueproperties
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Tight docking of membranes before fusion represents a metastable state with unique properties

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