Synthetic mycobacterial diacyl trehaloses reveal differential recognition by human T cell receptors and the C-type lectin Mincle
Abstract The cell wall of Mycobacterium tuberculosis is composed of diverse glycolipids which potentially interact with the human immune system. To overcome difficulties in obtaining pure compounds from bacterial extracts, we recently synthesized three forms of mycobacterial diacyltrehalose (DAT) th...
Guardado en:
Autores principales: | Josephine F. Reijneveld, Mira Holzheimer, David C. Young, Kattya Lopez, Sara Suliman, Judith Jimenez, Roger Calderon, Leonid Lecca, Megan B. Murray, Eri Ishikawa, Sho Yamasaki, Adriaan J. Minnaard, D. Branch Moody, Ildiko Van Rhijn |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/90220270f20747fdaf524d58aa1ac4a7 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Neutrophils Promote Mycobacterial Trehalose Dimycolate-Induced Lung Inflammation via the Mincle Pathway.
por: Wook-Bin Lee, et al.
Publicado: (2012) -
A T-cell receptor escape channel allows broad T-cell response to CD1b and membrane phospholipids
por: Adam Shahine, et al.
Publicado: (2019) -
Trehalose Recycling Promotes Energy-Efficient Biosynthesis of the Mycobacterial Cell Envelope
por: Amol Arunrao Pohane, et al.
Publicado: (2021) -
NOD1/2 and the C-Type Lectin Receptors Dectin-1 and Mincle Synergistically Enhance Proinflammatory Reactions Both In Vitro and In Vivo
por: Tukhvatulin AI, et al.
Publicado: (2020) -
T cell receptor recognition of CD1b presenting a mycobacterial glycolipid
por: Stephanie Gras, et al.
Publicado: (2016)