MiR-27 as a prognostic marker for breast cancer progression and patient survival.

<h4>Background</h4>MicroRNA-27a (miR-27a) is thought to be an onco-microRNA that promotes tumor growth and metastasis by downregulating ZBTB10. The potential predictive value of miR-27a was studied in breast cancer patients.<h4>Methods</h4>The expression of miR-27a and ZBTB10...

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Autores principales:	Wei Tang, Jiujun Zhu, Shicheng Su, Wei Wu, Qiang Liu, Fengxi Su, Fengyan Yu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/902593b3509d4ac893cbae5cf481a8fb
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spelling	oai:doaj.org-article:902593b3509d4ac893cbae5cf481a8fb2021-11-18T08:05:31ZMiR-27 as a prognostic marker for breast cancer progression and patient survival.1932-620310.1371/journal.pone.0051702https://doaj.org/article/902593b3509d4ac893cbae5cf481a8fb2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23240057/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>MicroRNA-27a (miR-27a) is thought to be an onco-microRNA that promotes tumor growth and metastasis by downregulating ZBTB10. The potential predictive value of miR-27a was studied in breast cancer patients.<h4>Methods</h4>The expression of miR-27a and ZBTB10 was examined in 102 breast cancer cases using in situ hybridization (ISH) and immunohistochemistry techniques and were evaluated semi-quantitatively by examining the staining index. The Correlation of miR-27a and ZBTB10 expression was analyed by Spearman Rank Correlation. The association of miR-27a and ZBTB10 expression with clinicopathological characteristics was analyzed using the χ(2) test, and their effects on patient survival were analyzed by a log-rank test and the Kaplan-Meier method. Univariate and multivariate Cox regression analyses were used to evaluate the prognostic values of miR-27a and ZBTB10.<h4>Results</h4>miR-27a was markedly up-regulated in invasive breast cancers that expressed low levels of ZBTB10 (P<0.001). A reverse correlation between miR-27a and ZBTB10 was also observed in breast cancer tissue samples (r(s) = -0.478, P<0.001). Furthermore, the expression of miR-27a and ZBTB10 was significantly correlated with clinicopathological parameters, including tumor size, lymph node metastasis and distant metastasis (P<0.05), but not with receptor status. Patients with high miR-27a or low ZBTB10 expression tended to have significantly shorter disease-free survival times (57 months and 53 months, respectively, P <0.001) and overall survival times (58 months and 55 months, respectively, P <0.001). Univariate and multivariate analysis showed that both miR-27a and ZBTB10 were independent prognostic factors of disease-free survival in breast cancer patients (P <0.001), while only miR-27a was an independent predictor of overall survival (P <0.001).<h4>Conclusions</h4>High miR-27a expression is associated with poor overall survival in patients with breast cancer, which suggests that miR-27a could be a valuable marker of breast cancer progression.Wei TangJiujun ZhuShicheng SuWei WuQiang LiuFengxi SuFengyan YuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 12, p e51702 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wei Tang Jiujun Zhu Shicheng Su Wei Wu Qiang Liu Fengxi Su Fengyan Yu MiR-27 as a prognostic marker for breast cancer progression and patient survival.
description	<h4>Background</h4>MicroRNA-27a (miR-27a) is thought to be an onco-microRNA that promotes tumor growth and metastasis by downregulating ZBTB10. The potential predictive value of miR-27a was studied in breast cancer patients.<h4>Methods</h4>The expression of miR-27a and ZBTB10 was examined in 102 breast cancer cases using in situ hybridization (ISH) and immunohistochemistry techniques and were evaluated semi-quantitatively by examining the staining index. The Correlation of miR-27a and ZBTB10 expression was analyed by Spearman Rank Correlation. The association of miR-27a and ZBTB10 expression with clinicopathological characteristics was analyzed using the χ(2) test, and their effects on patient survival were analyzed by a log-rank test and the Kaplan-Meier method. Univariate and multivariate Cox regression analyses were used to evaluate the prognostic values of miR-27a and ZBTB10.<h4>Results</h4>miR-27a was markedly up-regulated in invasive breast cancers that expressed low levels of ZBTB10 (P<0.001). A reverse correlation between miR-27a and ZBTB10 was also observed in breast cancer tissue samples (r(s) = -0.478, P<0.001). Furthermore, the expression of miR-27a and ZBTB10 was significantly correlated with clinicopathological parameters, including tumor size, lymph node metastasis and distant metastasis (P<0.05), but not with receptor status. Patients with high miR-27a or low ZBTB10 expression tended to have significantly shorter disease-free survival times (57 months and 53 months, respectively, P <0.001) and overall survival times (58 months and 55 months, respectively, P <0.001). Univariate and multivariate analysis showed that both miR-27a and ZBTB10 were independent prognostic factors of disease-free survival in breast cancer patients (P <0.001), while only miR-27a was an independent predictor of overall survival (P <0.001).<h4>Conclusions</h4>High miR-27a expression is associated with poor overall survival in patients with breast cancer, which suggests that miR-27a could be a valuable marker of breast cancer progression.
format	article
author	Wei Tang Jiujun Zhu Shicheng Su Wei Wu Qiang Liu Fengxi Su Fengyan Yu
author_facet	Wei Tang Jiujun Zhu Shicheng Su Wei Wu Qiang Liu Fengxi Su Fengyan Yu
author_sort	Wei Tang
title	MiR-27 as a prognostic marker for breast cancer progression and patient survival.
title_short	MiR-27 as a prognostic marker for breast cancer progression and patient survival.
title_full	MiR-27 as a prognostic marker for breast cancer progression and patient survival.
title_fullStr	MiR-27 as a prognostic marker for breast cancer progression and patient survival.
title_full_unstemmed	MiR-27 as a prognostic marker for breast cancer progression and patient survival.
title_sort	mir-27 as a prognostic marker for breast cancer progression and patient survival.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/902593b3509d4ac893cbae5cf481a8fb
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MiR-27 as a prognostic marker for breast cancer progression and patient survival.

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