Clinical and morphological case of developing liver cirrhosis associated with viral hepatitis in a young patient

The significance of chronic hepatitis is determined not only by the disease per se, but also by the increased risk of the formation of long-term adverse effects such as liver cirrhosis. Viral cirrhosis of the liver (as the outcome of chronic hepatitis B, C, B + D) comprise from 10% to 24.5% of all l...

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Autores principales:	O. V. Vorobeva, A. V. Lastochkin
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2021
Materias:	cirrhosis liver viral hepatitis edema necronephrosis morphology Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/9025d954a3c44903b030f27f4e2bb65b
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spelling	oai:doaj.org-article:9025d954a3c44903b030f27f4e2bb65b2021-11-22T07:09:55ZClinical and morphological case of developing liver cirrhosis associated with viral hepatitis in a young patient2220-76192313-739810.15789/2220-7619-CAM-1330https://doaj.org/article/9025d954a3c44903b030f27f4e2bb65b2021-09-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/1330https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398The significance of chronic hepatitis is determined not only by the disease per se, but also by the increased risk of the formation of long-term adverse effects such as liver cirrhosis. Viral cirrhosis of the liver (as the outcome of chronic hepatitis B, C, B + D) comprise from 10% to 24.5% of all liver cirrhosis cases. Cirrhosis of the liver is considered as an irreversible stage of chronic hepatitis, more often observed in men above 40 years, but recently more and more its cases are found in young, working ones leading to disability. Due to the high liver regenerative potential, a prognosis for liver lesions of different etiologies may be rather favorable. As a result, early diagnostics, dynamic monitoring and the use of promising methods for treating liver pathology to stimulate its regeneration that compensates for lost liver functions are necessary. In the clinical and morphological case, pathomorphological changes in organs with liver cirrhosis, which developed as a result of viral hepatitis are described. The aim of the study was to describe pathomorphological changes in organs during liver cirrhosis, which developed due to viral hepatitis, which led to multiple organ failure in a young patient. Materials and methods. The analysis of the obtained accompanying medical documentation (outpatient card, medical history) was performed. The standard methodology of autopsy was used. To process histological sections of autopsy material, hematoxylin-eosin staining was used. Results. Histological examination in the liver shows development of portal tract fibrosis with lymphohistio cytic infiltration, formation of monolobular regenerated nodes, signs of edema, areas of demyelination, dystrophic changes in neurocytes, signs of acute renal failure, a combined profound change in the kidneys detected in the lungs and brain, which resulted in multiple organ failure and subsequent lethal outcome in a young patient. The early formation of portal hypertension with liver cirrhosis, esophageal and gastric varicose veins dilatation lead to fatal bleeding in half of patients. Therefore, timely diagnosed cirrhosis and hepatitis as their predecessors is one of the most relevant issues in medicine.O. V. VorobevaA. V. LastochkinSankt-Peterburg : NIIÈM imeni Pasteraarticlecirrhosisliverviral hepatitisedemanecronephrosismorphologyInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 11, Iss 4, Pp 784-788 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	cirrhosis liver viral hepatitis edema necronephrosis morphology Infectious and parasitic diseases RC109-216
spellingShingle	cirrhosis liver viral hepatitis edema necronephrosis morphology Infectious and parasitic diseases RC109-216 O. V. Vorobeva A. V. Lastochkin Clinical and morphological case of developing liver cirrhosis associated with viral hepatitis in a young patient
description	The significance of chronic hepatitis is determined not only by the disease per se, but also by the increased risk of the formation of long-term adverse effects such as liver cirrhosis. Viral cirrhosis of the liver (as the outcome of chronic hepatitis B, C, B + D) comprise from 10% to 24.5% of all liver cirrhosis cases. Cirrhosis of the liver is considered as an irreversible stage of chronic hepatitis, more often observed in men above 40 years, but recently more and more its cases are found in young, working ones leading to disability. Due to the high liver regenerative potential, a prognosis for liver lesions of different etiologies may be rather favorable. As a result, early diagnostics, dynamic monitoring and the use of promising methods for treating liver pathology to stimulate its regeneration that compensates for lost liver functions are necessary. In the clinical and morphological case, pathomorphological changes in organs with liver cirrhosis, which developed as a result of viral hepatitis are described. The aim of the study was to describe pathomorphological changes in organs during liver cirrhosis, which developed due to viral hepatitis, which led to multiple organ failure in a young patient. Materials and methods. The analysis of the obtained accompanying medical documentation (outpatient card, medical history) was performed. The standard methodology of autopsy was used. To process histological sections of autopsy material, hematoxylin-eosin staining was used. Results. Histological examination in the liver shows development of portal tract fibrosis with lymphohistio cytic infiltration, formation of monolobular regenerated nodes, signs of edema, areas of demyelination, dystrophic changes in neurocytes, signs of acute renal failure, a combined profound change in the kidneys detected in the lungs and brain, which resulted in multiple organ failure and subsequent lethal outcome in a young patient. The early formation of portal hypertension with liver cirrhosis, esophageal and gastric varicose veins dilatation lead to fatal bleeding in half of patients. Therefore, timely diagnosed cirrhosis and hepatitis as their predecessors is one of the most relevant issues in medicine.
format	article
author	O. V. Vorobeva A. V. Lastochkin
author_facet	O. V. Vorobeva A. V. Lastochkin
author_sort	O. V. Vorobeva
title	Clinical and morphological case of developing liver cirrhosis associated with viral hepatitis in a young patient
title_short	Clinical and morphological case of developing liver cirrhosis associated with viral hepatitis in a young patient
title_full	Clinical and morphological case of developing liver cirrhosis associated with viral hepatitis in a young patient
title_fullStr	Clinical and morphological case of developing liver cirrhosis associated with viral hepatitis in a young patient
title_full_unstemmed	Clinical and morphological case of developing liver cirrhosis associated with viral hepatitis in a young patient
title_sort	clinical and morphological case of developing liver cirrhosis associated with viral hepatitis in a young patient
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2021
url	https://doaj.org/article/9025d954a3c44903b030f27f4e2bb65b
work_keys_str_mv	AT ovvorobeva clinicalandmorphologicalcaseofdevelopinglivercirrhosisassociatedwithviralhepatitisinayoungpatient AT avlastochkin clinicalandmorphologicalcaseofdevelopinglivercirrhosisassociatedwithviralhepatitisinayoungpatient
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Clinical and morphological case of developing liver cirrhosis associated with viral hepatitis in a young patient

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