Hospitalization for acute coronary syndrome increases the long-term risk of pneumonia: a population-based cohort study

Abstract It is well established that the risk of acute coronary syndrome (ACS) increases after respiratory infection. However, the reverse association has not been evaluated. We tested the hypothesis that the long-term risk of pneumonia is increased after a new ACS event. A matched-cohort study was...

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Autores principales:	Joonghee Kim, Sang Jun Park, Sangbum Choi, Won-woo Seo, Yeon Joo Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9026bfcb576c4a36942d8cde2bdd91ae
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spelling	oai:doaj.org-article:9026bfcb576c4a36942d8cde2bdd91ae2021-12-02T15:38:23ZHospitalization for acute coronary syndrome increases the long-term risk of pneumonia: a population-based cohort study10.1038/s41598-021-89038-12045-2322https://doaj.org/article/9026bfcb576c4a36942d8cde2bdd91ae2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89038-1https://doaj.org/toc/2045-2322Abstract It is well established that the risk of acute coronary syndrome (ACS) increases after respiratory infection. However, the reverse association has not been evaluated. We tested the hypothesis that the long-term risk of pneumonia is increased after a new ACS event. A matched-cohort study was conducted using a nationally representative dataset. We identified patients with admission for ACS between 2004 and 2014, without a previous history of ACS or pneumonia. Incidence density sampling was used to match patients, on the basis of age and sex, to 3 controls who were also free from both ACS and pneumonia. We examined the incidence of pneumonia after ACS until the end of the cohort observation (Dec 31, 2014). The analysis cohort consisted of 5469 ACS cases and 16,392 controls (median age, 64 years; 68.3% men). The incidence rate ratios of the first and the total pneumonia episodes in the ACS group relative to the control group was 1.25 (95% confidence interval [CI], 1.11–1.41) and 1.23(95% CI 1.11–1.36), respectively. A significant ACS-related increase in the incidence of pneumonia was observed in the Cox-regression, shared frailty, and joint frailty model analyses, with hazard ratios of 1.25 (95% CI 1.09–1.42), 1.35 (95% CI 1.15–1.58), and 1.24 (95% CI 1.10–1.39), respectively. In this population-based cohort of patients who were initially free from both ACS and pneumonia, we found that hospitalization for ACS substantially increased the long term risk of pneumonia. This should be considered when formulating post-discharge care plans and preventive vaccination strategies in patients with ACS.Joonghee KimSang Jun ParkSangbum ChoiWon-woo SeoYeon Joo LeeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Joonghee Kim Sang Jun Park Sangbum Choi Won-woo Seo Yeon Joo Lee Hospitalization for acute coronary syndrome increases the long-term risk of pneumonia: a population-based cohort study
description	Abstract It is well established that the risk of acute coronary syndrome (ACS) increases after respiratory infection. However, the reverse association has not been evaluated. We tested the hypothesis that the long-term risk of pneumonia is increased after a new ACS event. A matched-cohort study was conducted using a nationally representative dataset. We identified patients with admission for ACS between 2004 and 2014, without a previous history of ACS or pneumonia. Incidence density sampling was used to match patients, on the basis of age and sex, to 3 controls who were also free from both ACS and pneumonia. We examined the incidence of pneumonia after ACS until the end of the cohort observation (Dec 31, 2014). The analysis cohort consisted of 5469 ACS cases and 16,392 controls (median age, 64 years; 68.3% men). The incidence rate ratios of the first and the total pneumonia episodes in the ACS group relative to the control group was 1.25 (95% confidence interval [CI], 1.11–1.41) and 1.23(95% CI 1.11–1.36), respectively. A significant ACS-related increase in the incidence of pneumonia was observed in the Cox-regression, shared frailty, and joint frailty model analyses, with hazard ratios of 1.25 (95% CI 1.09–1.42), 1.35 (95% CI 1.15–1.58), and 1.24 (95% CI 1.10–1.39), respectively. In this population-based cohort of patients who were initially free from both ACS and pneumonia, we found that hospitalization for ACS substantially increased the long term risk of pneumonia. This should be considered when formulating post-discharge care plans and preventive vaccination strategies in patients with ACS.
format	article
author	Joonghee Kim Sang Jun Park Sangbum Choi Won-woo Seo Yeon Joo Lee
author_facet	Joonghee Kim Sang Jun Park Sangbum Choi Won-woo Seo Yeon Joo Lee
author_sort	Joonghee Kim
title	Hospitalization for acute coronary syndrome increases the long-term risk of pneumonia: a population-based cohort study
title_short	Hospitalization for acute coronary syndrome increases the long-term risk of pneumonia: a population-based cohort study
title_full	Hospitalization for acute coronary syndrome increases the long-term risk of pneumonia: a population-based cohort study
title_fullStr	Hospitalization for acute coronary syndrome increases the long-term risk of pneumonia: a population-based cohort study
title_full_unstemmed	Hospitalization for acute coronary syndrome increases the long-term risk of pneumonia: a population-based cohort study
title_sort	hospitalization for acute coronary syndrome increases the long-term risk of pneumonia: a population-based cohort study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9026bfcb576c4a36942d8cde2bdd91ae
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Hospitalization for acute coronary syndrome increases the long-term risk of pneumonia: a population-based cohort study

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