Premature ventricular contraction increases the risk of heart failure and ventricular tachyarrhythmia

Abstract Premature ventricular contraction (PVC), a common arrhythmia affecting 1–2% of the general population, has been considered to have a benign clinical course. However, people with PVC often develop heart failure and ventricular arrhythmias such as ventricular tachycardia. We aimed to clarify...

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Autores principales:	Yun Gi Kim, Yun Young Choi, Kyung-Do Han, Kyoung Jin Min, Ha Young Choi, Jaemin Shim, Jong-Il Choi, Young-Hoon Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9029321e863d47d48c1a5ce6c796129b
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spelling	oai:doaj.org-article:9029321e863d47d48c1a5ce6c796129b2021-12-02T17:23:50ZPremature ventricular contraction increases the risk of heart failure and ventricular tachyarrhythmia10.1038/s41598-021-92088-02045-2322https://doaj.org/article/9029321e863d47d48c1a5ce6c796129b2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92088-0https://doaj.org/toc/2045-2322Abstract Premature ventricular contraction (PVC), a common arrhythmia affecting 1–2% of the general population, has been considered to have a benign clinical course. However, people with PVC often develop heart failure and ventricular arrhythmias such as ventricular tachycardia. We aimed to clarify the risk of heart failure and lethal ventricular arrhythmias in people with PVC. The Korean National Health Insurance Service database was used for this study. People who underwent nationwide health check-ups in 2009 were enrolled in this study and clinical follow-up data until December 2018 were analyzed. Newly diagnosed PVC in 2009 (≥ 1 inpatient or outpatient claim) were identified and cumulative incidence of heart failure (≥ 1 inpatient claim) and ventricular arrhythmias (≥ 1 inpatient or outpatient claim) were compared. A total of 4515 people were first diagnosed with PVC in 2009 among 9,743,582 people without prior history of PVC, heart failure, or ventricular arrhythmias. People with newly diagnosed PVC in 2009 had a significantly higher incidence of heart failure compared to those without PVC [adjusted hazard ratio (HR) 1.371; 95% confidence interval (CI) 1.177–1.598; p < 0.001]. Significant interaction was observed between age and PVC with young age people at greater risk of developing heart failure for having PVC. The incidence of ventricular arrhythmia was also significantly increased in people with PVC (HR 5.588; 95% CI 4.553–6.859; p < 0.001). Age and chronic kidney disease had significant interactions with PVC. In conclusion, the incidence of heart failure and ventricular arrhythmia was significantly increased in people with PVC. Outpatient follow-up of people with PVC can be helpful to detect early signs of heart failure or advanced forms of ventricular arrhythmia.Yun Gi KimYun Young ChoiKyung-Do HanKyoung Jin MinHa Young ChoiJaemin ShimJong-Il ChoiYoung-Hoon KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yun Gi Kim Yun Young Choi Kyung-Do Han Kyoung Jin Min Ha Young Choi Jaemin Shim Jong-Il Choi Young-Hoon Kim Premature ventricular contraction increases the risk of heart failure and ventricular tachyarrhythmia
description	Abstract Premature ventricular contraction (PVC), a common arrhythmia affecting 1–2% of the general population, has been considered to have a benign clinical course. However, people with PVC often develop heart failure and ventricular arrhythmias such as ventricular tachycardia. We aimed to clarify the risk of heart failure and lethal ventricular arrhythmias in people with PVC. The Korean National Health Insurance Service database was used for this study. People who underwent nationwide health check-ups in 2009 were enrolled in this study and clinical follow-up data until December 2018 were analyzed. Newly diagnosed PVC in 2009 (≥ 1 inpatient or outpatient claim) were identified and cumulative incidence of heart failure (≥ 1 inpatient claim) and ventricular arrhythmias (≥ 1 inpatient or outpatient claim) were compared. A total of 4515 people were first diagnosed with PVC in 2009 among 9,743,582 people without prior history of PVC, heart failure, or ventricular arrhythmias. People with newly diagnosed PVC in 2009 had a significantly higher incidence of heart failure compared to those without PVC [adjusted hazard ratio (HR) 1.371; 95% confidence interval (CI) 1.177–1.598; p < 0.001]. Significant interaction was observed between age and PVC with young age people at greater risk of developing heart failure for having PVC. The incidence of ventricular arrhythmia was also significantly increased in people with PVC (HR 5.588; 95% CI 4.553–6.859; p < 0.001). Age and chronic kidney disease had significant interactions with PVC. In conclusion, the incidence of heart failure and ventricular arrhythmia was significantly increased in people with PVC. Outpatient follow-up of people with PVC can be helpful to detect early signs of heart failure or advanced forms of ventricular arrhythmia.
format	article
author	Yun Gi Kim Yun Young Choi Kyung-Do Han Kyoung Jin Min Ha Young Choi Jaemin Shim Jong-Il Choi Young-Hoon Kim
author_facet	Yun Gi Kim Yun Young Choi Kyung-Do Han Kyoung Jin Min Ha Young Choi Jaemin Shim Jong-Il Choi Young-Hoon Kim
author_sort	Yun Gi Kim
title	Premature ventricular contraction increases the risk of heart failure and ventricular tachyarrhythmia
title_short	Premature ventricular contraction increases the risk of heart failure and ventricular tachyarrhythmia
title_full	Premature ventricular contraction increases the risk of heart failure and ventricular tachyarrhythmia
title_fullStr	Premature ventricular contraction increases the risk of heart failure and ventricular tachyarrhythmia
title_full_unstemmed	Premature ventricular contraction increases the risk of heart failure and ventricular tachyarrhythmia
title_sort	premature ventricular contraction increases the risk of heart failure and ventricular tachyarrhythmia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9029321e863d47d48c1a5ce6c796129b
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Premature ventricular contraction increases the risk of heart failure and ventricular tachyarrhythmia

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