Multiple Eyelid Signs are Suggestive of Demodex Infestation

Lunla Udomwech, Nonthapan Phasuk School of Medicine, Walailak University, Nakhon Si Thammarat, ThailandCorrespondence: Lunla UdomwechSchool of Medicine, Walailak University, 222 Thaiburi, Tha Sala, Nakhon Si Thammarat, 80160, ThailandTel +6675 672 801Fax +6675 672 807Email lunla.ud@wu.ac.thPurpose:...

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Autores principales:	Udomwech L, Phasuk N
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	demodex blepharitis eyelid signs debris thailand Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/902ad3f846da405d9a34dc4808b5bdb7
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spelling	oai:doaj.org-article:902ad3f846da405d9a34dc4808b5bdb72021-12-02T14:12:25ZMultiple Eyelid Signs are Suggestive of Demodex Infestation1177-5483https://doaj.org/article/902ad3f846da405d9a34dc4808b5bdb72021-02-01T00:00:00Zhttps://www.dovepress.com/multiple-eyelid-signs-are-suggestive-of-demodex-infestation-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Lunla Udomwech, Nonthapan Phasuk School of Medicine, Walailak University, Nakhon Si Thammarat, ThailandCorrespondence: Lunla UdomwechSchool of Medicine, Walailak University, 222 Thaiburi, Tha Sala, Nakhon Si Thammarat, 80160, ThailandTel +6675 672 801Fax +6675 672 807Email lunla.ud@wu.ac.thPurpose: To determine the signs associated with Demodex infestation in blepharitis patients and the rates of eyelash Demodex colonization among blepharitic patients and healthy individuals in Thailand.Patients and Methods: This was a prospective, case–control clinical study. Eighty-three controls and 43 blepharitic patients were consecutively enrolled from Walailak University Hospital. Each patient answered a questionnaire, underwent a complete eye exam, and had four lashes from each eye epilated; eyelashes were directly examined under a light microscope. Ocular signs, including types of eyelash debris (waxy debris, scaly debris, or cylindrical dandruff (CD)), erythema and telangiectasia of the eyelid, were noted.Results: Demodex infestation was observed more frequently among patients with blepharitis than among controls (67.4% in the blepharitis group, 26.5% in the control group, p-value < 0.001). The participants with Demodex infestation were 5.7 times more likely to have blepharitis than the controls (odds ratio 5.74; 95% confidence interval 2.57– 12.82, p-value < 0.001). Clinical signs that were significantly (p-value < 0.05) related to demodicosis were lid erythema, lid telangiectasia, and any type of eyelash debris (scaly, waxy, or CD).Conclusion: In contrast to previous studies that found only CD to be highly associated with eyelash demodicosis, we found multiple suggestive signs: any kind of debris on eyelashes (scaly, waxy, or CD), eyelid erythema, and eyelid telangiectasia. Approximately one-quarter (26.5%) of the studied population had asymptomatic mite colonization. Demodex infestation should therefore always be on the list of possible etiologies when treating patients with blepharitis or other ocular surface-related problems.Keywords: Demodex, blepharitis, eyelid signs, debris, ThailandUdomwech LPhasuk NDove Medical Pressarticledemodexblepharitiseyelid signsdebristhailandOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 15, Pp 671-678 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	demodex blepharitis eyelid signs debris thailand Ophthalmology RE1-994
spellingShingle	demodex blepharitis eyelid signs debris thailand Ophthalmology RE1-994 Udomwech L Phasuk N Multiple Eyelid Signs are Suggestive of Demodex Infestation
description	Lunla Udomwech, Nonthapan Phasuk School of Medicine, Walailak University, Nakhon Si Thammarat, ThailandCorrespondence: Lunla UdomwechSchool of Medicine, Walailak University, 222 Thaiburi, Tha Sala, Nakhon Si Thammarat, 80160, ThailandTel +6675 672 801Fax +6675 672 807Email lunla.ud@wu.ac.thPurpose: To determine the signs associated with Demodex infestation in blepharitis patients and the rates of eyelash Demodex colonization among blepharitic patients and healthy individuals in Thailand.Patients and Methods: This was a prospective, case–control clinical study. Eighty-three controls and 43 blepharitic patients were consecutively enrolled from Walailak University Hospital. Each patient answered a questionnaire, underwent a complete eye exam, and had four lashes from each eye epilated; eyelashes were directly examined under a light microscope. Ocular signs, including types of eyelash debris (waxy debris, scaly debris, or cylindrical dandruff (CD)), erythema and telangiectasia of the eyelid, were noted.Results: Demodex infestation was observed more frequently among patients with blepharitis than among controls (67.4% in the blepharitis group, 26.5% in the control group, p-value < 0.001). The participants with Demodex infestation were 5.7 times more likely to have blepharitis than the controls (odds ratio 5.74; 95% confidence interval 2.57– 12.82, p-value < 0.001). Clinical signs that were significantly (p-value < 0.05) related to demodicosis were lid erythema, lid telangiectasia, and any type of eyelash debris (scaly, waxy, or CD).Conclusion: In contrast to previous studies that found only CD to be highly associated with eyelash demodicosis, we found multiple suggestive signs: any kind of debris on eyelashes (scaly, waxy, or CD), eyelid erythema, and eyelid telangiectasia. Approximately one-quarter (26.5%) of the studied population had asymptomatic mite colonization. Demodex infestation should therefore always be on the list of possible etiologies when treating patients with blepharitis or other ocular surface-related problems.Keywords: Demodex, blepharitis, eyelid signs, debris, Thailand
format	article
author	Udomwech L Phasuk N
author_facet	Udomwech L Phasuk N
author_sort	Udomwech L
title	Multiple Eyelid Signs are Suggestive of Demodex Infestation
title_short	Multiple Eyelid Signs are Suggestive of Demodex Infestation
title_full	Multiple Eyelid Signs are Suggestive of Demodex Infestation
title_fullStr	Multiple Eyelid Signs are Suggestive of Demodex Infestation
title_full_unstemmed	Multiple Eyelid Signs are Suggestive of Demodex Infestation
title_sort	multiple eyelid signs are suggestive of demodex infestation
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/902ad3f846da405d9a34dc4808b5bdb7
work_keys_str_mv	AT udomwechl multipleeyelidsignsaresuggestiveofdemodexinfestation AT phasukn multipleeyelidsignsaresuggestiveofdemodexinfestation
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Multiple Eyelid Signs are Suggestive of Demodex Infestation

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