Biomarkers and Dynamic Cerebral Autoregulation of Obstructive Sleep Apnea-Hypopnea Syndrome

Yanan Zhang,1 Xiaodan Wu,1 Qingqing Sun,1 Qi Tang,1 Zhen-Ni Guo,2 Zan Wang,1 Yi Yang2 1Department of Neurology and Neuroscience Center, the First Hospital of Jilin University, Changchun, People’s Republic of China; 2Department of Neurology and Neuroscience Center, Clinical Trial and Research Center...

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Autores principales:	Zhang Y, Wu X, Sun Q, Tang Q, Guo ZN, Wang Z, Yang Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	obstructive sleep apnea-hypopnea syndrome apolipoprotein b-100 fibronectin ceruloplasmin dynamic cerebral autoregulation Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
Acceso en línea:	https://doaj.org/article/902ca4160cfa444b9a4be1f17400d9db
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spelling	oai:doaj.org-article:902ca4160cfa444b9a4be1f17400d9db2021-12-02T18:20:36ZBiomarkers and Dynamic Cerebral Autoregulation of Obstructive Sleep Apnea-Hypopnea Syndrome1179-1608https://doaj.org/article/902ca4160cfa444b9a4be1f17400d9db2021-11-01T00:00:00Zhttps://www.dovepress.com/biomarkers-and-dynamic-cerebral-autoregulation-of-obstructive-sleep-ap-peer-reviewed-fulltext-article-NSShttps://doaj.org/toc/1179-1608Yanan Zhang,1 Xiaodan Wu,1 Qingqing Sun,1 Qi Tang,1 Zhen-Ni Guo,2 Zan Wang,1 Yi Yang2 1Department of Neurology and Neuroscience Center, the First Hospital of Jilin University, Changchun, People’s Republic of China; 2Department of Neurology and Neuroscience Center, Clinical Trial and Research Center for Stroke, the First Hospital of Jilin University, Changchun, People’s Republic of ChinaCorrespondence: Zan WangDepartment of Neurology and Neuroscience Center, the First Hospital of Jilin University, Changchun, People’s Republic of ChinaEmail wangzan@jlu.edu.cn; wangzanprof@163.comYi YangDepartment of Neurology and Neuroscience Center, Clinical Trial and Research Center for Stroke, the First Hospital of Jilin University, Changchun, People’s Republic of ChinaEmail yang_yi@jlu.edu.cn; doctoryangyi@163.comObjective: Patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) have impaired dynamic cerebral autoregulation (dCA). This study aimed to explore whether serum levels of apolipoprotein B-100 (ApoB-100), fibronectin (FN), and ceruloplasmin (CP) were related to impaired dCA in OSAHS.Methods: A total of 90 patients with OSAHS from our database management system were enrolled and further divided into three subgroups according to the apnea-hypopnea index (AHI) using polysomnography results: mild (5 ≤ AHI ≤ 15), moderate (15 < AHI ≤ 30), and severe OSAHS (AHI > 30), with 30 patients in each group. Thirty sex- and age-matched healthy controls were recruited for this study. The serum levels of ApoB-100, FN, and CP were measured by enzyme-linked immunosorbent assays. dCA was assessed by analyzing the phase difference (PD) using transfer function analysis.Results: Serum levels of ApoB-100, FN, and CP were significantly higher in the mild, moderate, and severe OSAHS groups than that in the control group (P< 0.001, respectively). The average PD of the moderate and severe OSAHS groups was lower than that of the control group (P=0.001 and P< 0.001, respectively). Receiver operating curve analysis revealed that ApoB-100, FN, and CP might be able to distinguish patients with OSAHS from healthy individuals (area under the curve = 0.959 [95% CI 0.92– 1.00], 0.987 [95% CI 0.96– 1.01], 0.982 [95% CI 0.96– 1.00]), respectively, P< 0.001). The average PD was linearly correlated with the serum levels of ApoB-100, FN, and CP in patients with OSAHS. Multivariable analysis showed that FN and arousal index in polysomnography were associated with impaired average PD (P< 0.001 and P=0.025, respectively).Conclusion: Serum levels of ApoB-100, FN, and CP increased in patients with OSAHS. dCA was compromised in patients with OSAHS and was positively correlated with ApoB-100, FN, and CP serum levels, and FN serum levels and arousal index in polysomnography were independently associated with impaired dCA.Keywords: obstructive sleep apnea-hypopnea syndrome, apolipoprotein B-100, fibronectin, ceruloplasmin, dynamic cerebral autoregulationZhang YWu XSun QTang QGuo ZNWang ZYang YDove Medical Pressarticleobstructive sleep apnea-hypopnea syndromeapolipoprotein b-100fibronectinceruloplasmindynamic cerebral autoregulationPsychiatryRC435-571Neurophysiology and neuropsychologyQP351-495ENNature and Science of Sleep, Vol Volume 13, Pp 2019-2028 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	obstructive sleep apnea-hypopnea syndrome apolipoprotein b-100 fibronectin ceruloplasmin dynamic cerebral autoregulation Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
spellingShingle	obstructive sleep apnea-hypopnea syndrome apolipoprotein b-100 fibronectin ceruloplasmin dynamic cerebral autoregulation Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495 Zhang Y Wu X Sun Q Tang Q Guo ZN Wang Z Yang Y Biomarkers and Dynamic Cerebral Autoregulation of Obstructive Sleep Apnea-Hypopnea Syndrome
description	Yanan Zhang,1 Xiaodan Wu,1 Qingqing Sun,1 Qi Tang,1 Zhen-Ni Guo,2 Zan Wang,1 Yi Yang2 1Department of Neurology and Neuroscience Center, the First Hospital of Jilin University, Changchun, People’s Republic of China; 2Department of Neurology and Neuroscience Center, Clinical Trial and Research Center for Stroke, the First Hospital of Jilin University, Changchun, People’s Republic of ChinaCorrespondence: Zan WangDepartment of Neurology and Neuroscience Center, the First Hospital of Jilin University, Changchun, People’s Republic of ChinaEmail wangzan@jlu.edu.cn; wangzanprof@163.comYi YangDepartment of Neurology and Neuroscience Center, Clinical Trial and Research Center for Stroke, the First Hospital of Jilin University, Changchun, People’s Republic of ChinaEmail yang_yi@jlu.edu.cn; doctoryangyi@163.comObjective: Patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) have impaired dynamic cerebral autoregulation (dCA). This study aimed to explore whether serum levels of apolipoprotein B-100 (ApoB-100), fibronectin (FN), and ceruloplasmin (CP) were related to impaired dCA in OSAHS.Methods: A total of 90 patients with OSAHS from our database management system were enrolled and further divided into three subgroups according to the apnea-hypopnea index (AHI) using polysomnography results: mild (5 ≤ AHI ≤ 15), moderate (15 < AHI ≤ 30), and severe OSAHS (AHI > 30), with 30 patients in each group. Thirty sex- and age-matched healthy controls were recruited for this study. The serum levels of ApoB-100, FN, and CP were measured by enzyme-linked immunosorbent assays. dCA was assessed by analyzing the phase difference (PD) using transfer function analysis.Results: Serum levels of ApoB-100, FN, and CP were significantly higher in the mild, moderate, and severe OSAHS groups than that in the control group (P< 0.001, respectively). The average PD of the moderate and severe OSAHS groups was lower than that of the control group (P=0.001 and P< 0.001, respectively). Receiver operating curve analysis revealed that ApoB-100, FN, and CP might be able to distinguish patients with OSAHS from healthy individuals (area under the curve = 0.959 [95% CI 0.92– 1.00], 0.987 [95% CI 0.96– 1.01], 0.982 [95% CI 0.96– 1.00]), respectively, P< 0.001). The average PD was linearly correlated with the serum levels of ApoB-100, FN, and CP in patients with OSAHS. Multivariable analysis showed that FN and arousal index in polysomnography were associated with impaired average PD (P< 0.001 and P=0.025, respectively).Conclusion: Serum levels of ApoB-100, FN, and CP increased in patients with OSAHS. dCA was compromised in patients with OSAHS and was positively correlated with ApoB-100, FN, and CP serum levels, and FN serum levels and arousal index in polysomnography were independently associated with impaired dCA.Keywords: obstructive sleep apnea-hypopnea syndrome, apolipoprotein B-100, fibronectin, ceruloplasmin, dynamic cerebral autoregulation
format	article
author	Zhang Y Wu X Sun Q Tang Q Guo ZN Wang Z Yang Y
author_facet	Zhang Y Wu X Sun Q Tang Q Guo ZN Wang Z Yang Y
author_sort	Zhang Y
title	Biomarkers and Dynamic Cerebral Autoregulation of Obstructive Sleep Apnea-Hypopnea Syndrome
title_short	Biomarkers and Dynamic Cerebral Autoregulation of Obstructive Sleep Apnea-Hypopnea Syndrome
title_full	Biomarkers and Dynamic Cerebral Autoregulation of Obstructive Sleep Apnea-Hypopnea Syndrome
title_fullStr	Biomarkers and Dynamic Cerebral Autoregulation of Obstructive Sleep Apnea-Hypopnea Syndrome
title_full_unstemmed	Biomarkers and Dynamic Cerebral Autoregulation of Obstructive Sleep Apnea-Hypopnea Syndrome
title_sort	biomarkers and dynamic cerebral autoregulation of obstructive sleep apnea-hypopnea syndrome
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/902ca4160cfa444b9a4be1f17400d9db
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Biomarkers and Dynamic Cerebral Autoregulation of Obstructive Sleep Apnea-Hypopnea Syndrome

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