The ER membrane-anchored ubiquitin ligase Hrd1 is a positive regulator of T-cell immunity

The ER membrane-anchored ubiquitin ligase Hrd1 is a positive regulator of T-cell immunity

Hrd1 is an E3 ubiquitin ligase involved in ER-associated degradation and MHC I turnover. Here the authors use T-cell-specific ko mice and a mouse model of multiple sclerosis to show that Hrd1 also drives pro-inflammatory T helper cell responses and contributes to pathogenesis of autoimmune disease.

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Detalles Bibliográficos
Autores principales: Yuanming Xu, Fang Zhao, Quan Qiu, Kun Chen, Juncheng Wei, Qingfei Kong, Beixue Gao, Johanna Melo-Cardenas, Bin Zhang, Jinping Zhang, Jianxun Song, Donna D. Zhang, Jianing Zhang, Yunping Fan, Huabin Li, Deyu Fang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
Materias:
Science
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Acceso en línea:https://doaj.org/article/902e7181d4964ee6a11b99d4dc6b4007
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Descripción
Sumario:Hrd1 is an E3 ubiquitin ligase involved in ER-associated degradation and MHC I turnover. Here the authors use T-cell-specific ko mice and a mouse model of multiple sclerosis to show that Hrd1 also drives pro-inflammatory T helper cell responses and contributes to pathogenesis of autoimmune disease.

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