The ER membrane-anchored ubiquitin ligase Hrd1 is a positive regulator of T-cell immunity

Hrd1 is an E3 ubiquitin ligase involved in ER-associated degradation and MHC I turnover. Here the authors use T-cell-specific ko mice and a mouse model of multiple sclerosis to show that Hrd1 also drives pro-inflammatory T helper cell responses and contributes to pathogenesis of autoimmune disease.

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Autores principales:	Yuanming Xu, Fang Zhao, Quan Qiu, Kun Chen, Juncheng Wei, Qingfei Kong, Beixue Gao, Johanna Melo-Cardenas, Bin Zhang, Jinping Zhang, Jianxun Song, Donna D. Zhang, Jianing Zhang, Yunping Fan, Huabin Li, Deyu Fang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/902e7181d4964ee6a11b99d4dc6b4007
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spelling	oai:doaj.org-article:902e7181d4964ee6a11b99d4dc6b40072021-12-02T14:39:51ZThe ER membrane-anchored ubiquitin ligase Hrd1 is a positive regulator of T-cell immunity10.1038/ncomms120732041-1723https://doaj.org/article/902e7181d4964ee6a11b99d4dc6b40072016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12073https://doaj.org/toc/2041-1723Hrd1 is an E3 ubiquitin ligase involved in ER-associated degradation and MHC I turnover. Here the authors use T-cell-specific ko mice and a mouse model of multiple sclerosis to show that Hrd1 also drives pro-inflammatory T helper cell responses and contributes to pathogenesis of autoimmune disease.Yuanming XuFang ZhaoQuan QiuKun ChenJuncheng WeiQingfei KongBeixue GaoJohanna Melo-CardenasBin ZhangJinping ZhangJianxun SongDonna D. ZhangJianing ZhangYunping FanHuabin LiDeyu FangNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yuanming Xu Fang Zhao Quan Qiu Kun Chen Juncheng Wei Qingfei Kong Beixue Gao Johanna Melo-Cardenas Bin Zhang Jinping Zhang Jianxun Song Donna D. Zhang Jianing Zhang Yunping Fan Huabin Li Deyu Fang The ER membrane-anchored ubiquitin ligase Hrd1 is a positive regulator of T-cell immunity
description	Hrd1 is an E3 ubiquitin ligase involved in ER-associated degradation and MHC I turnover. Here the authors use T-cell-specific ko mice and a mouse model of multiple sclerosis to show that Hrd1 also drives pro-inflammatory T helper cell responses and contributes to pathogenesis of autoimmune disease.
format	article
author	Yuanming Xu Fang Zhao Quan Qiu Kun Chen Juncheng Wei Qingfei Kong Beixue Gao Johanna Melo-Cardenas Bin Zhang Jinping Zhang Jianxun Song Donna D. Zhang Jianing Zhang Yunping Fan Huabin Li Deyu Fang
author_facet	Yuanming Xu Fang Zhao Quan Qiu Kun Chen Juncheng Wei Qingfei Kong Beixue Gao Johanna Melo-Cardenas Bin Zhang Jinping Zhang Jianxun Song Donna D. Zhang Jianing Zhang Yunping Fan Huabin Li Deyu Fang
author_sort	Yuanming Xu
title	The ER membrane-anchored ubiquitin ligase Hrd1 is a positive regulator of T-cell immunity
title_short	The ER membrane-anchored ubiquitin ligase Hrd1 is a positive regulator of T-cell immunity
title_full	The ER membrane-anchored ubiquitin ligase Hrd1 is a positive regulator of T-cell immunity
title_fullStr	The ER membrane-anchored ubiquitin ligase Hrd1 is a positive regulator of T-cell immunity
title_full_unstemmed	The ER membrane-anchored ubiquitin ligase Hrd1 is a positive regulator of T-cell immunity
title_sort	er membrane-anchored ubiquitin ligase hrd1 is a positive regulator of t-cell immunity
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/902e7181d4964ee6a11b99d4dc6b4007
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The ER membrane-anchored ubiquitin ligase Hrd1 is a positive regulator of T-cell immunity

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