A Narrative Review of Human Clinical Trials on the Impact of Phenolic-Rich Plant Extracts on Prediabetes and Its Subgroups

Phenolic-rich plant extracts have been demonstrated to improve glycemic control in individuals with prediabetes. However, there is increasing evidence that people with prediabetes are not a homogeneous group but exhibit different glycemic profiles leading to the existence of prediabetes subgroups. P...

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Autores principales:	Wen Xin Janice Lim, Cheryl S. Gammon, Pamela von Hurst, Lynne Chepulis, Rachel A. Page
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	functional food polyphenol impaired glycemic control impaired glucose tolerance impaired fasting glucose Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/9034910e4eae41b88bafc44d166d466a
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spelling	oai:doaj.org-article:9034910e4eae41b88bafc44d166d466a2021-11-25T18:33:35ZA Narrative Review of Human Clinical Trials on the Impact of Phenolic-Rich Plant Extracts on Prediabetes and Its Subgroups10.3390/nu131137332072-6643https://doaj.org/article/9034910e4eae41b88bafc44d166d466a2021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3733https://doaj.org/toc/2072-6643Phenolic-rich plant extracts have been demonstrated to improve glycemic control in individuals with prediabetes. However, there is increasing evidence that people with prediabetes are not a homogeneous group but exhibit different glycemic profiles leading to the existence of prediabetes subgroups. Prediabetes subgroups have been identified as: isolated impaired fasting glucose (IFG), isolated impaired glucose tolerance (IGT), and combined impaired fasting glucose and glucose intolerance (IFG/IGT). The present review investigates human clinical trials examining the hypoglycemic potential of phenolic-rich plant extracts in prediabetes and prediabetes subgroups. <i>Artemisia princeps</i> Pampanini, soy (<i>Glycine max</i> (L.) Merrill) leaf and <i>Citrus junos</i> Tanaka peel have been demonstrated to improve fasting glycemia and thus may be more useful for individuals with IFG with increasing hepatic insulin resistance. In contrast, white mulberry (<i>Morus alba</i> Linn.) leaf, persimmon (<i>Diospyros kaki</i>) leaf and <i>Acacia. Mearnsii</i> bark were shown to improve postprandial glycemia and hence may be preferably beneficial for individuals with IGT with increasing muscle insulin resistance. <i>Elaeis guineensis</i> leaf was observed to improve both fasting and postprandial glycemic measures depending on the dose. Current evidence remains scarce regarding the impact of the plant extracts on glycemic control in prediabetes subgroups and therefore warrants further study.Wen Xin Janice LimCheryl S. GammonPamela von HurstLynne ChepulisRachel A. PageMDPI AGarticlefunctional foodpolyphenolimpaired glycemic controlimpaired glucose toleranceimpaired fasting glucoseNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3733, p 3733 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	functional food polyphenol impaired glycemic control impaired glucose tolerance impaired fasting glucose Nutrition. Foods and food supply TX341-641
spellingShingle	functional food polyphenol impaired glycemic control impaired glucose tolerance impaired fasting glucose Nutrition. Foods and food supply TX341-641 Wen Xin Janice Lim Cheryl S. Gammon Pamela von Hurst Lynne Chepulis Rachel A. Page A Narrative Review of Human Clinical Trials on the Impact of Phenolic-Rich Plant Extracts on Prediabetes and Its Subgroups
description	Phenolic-rich plant extracts have been demonstrated to improve glycemic control in individuals with prediabetes. However, there is increasing evidence that people with prediabetes are not a homogeneous group but exhibit different glycemic profiles leading to the existence of prediabetes subgroups. Prediabetes subgroups have been identified as: isolated impaired fasting glucose (IFG), isolated impaired glucose tolerance (IGT), and combined impaired fasting glucose and glucose intolerance (IFG/IGT). The present review investigates human clinical trials examining the hypoglycemic potential of phenolic-rich plant extracts in prediabetes and prediabetes subgroups. <i>Artemisia princeps</i> Pampanini, soy (<i>Glycine max</i> (L.) Merrill) leaf and <i>Citrus junos</i> Tanaka peel have been demonstrated to improve fasting glycemia and thus may be more useful for individuals with IFG with increasing hepatic insulin resistance. In contrast, white mulberry (<i>Morus alba</i> Linn.) leaf, persimmon (<i>Diospyros kaki</i>) leaf and <i>Acacia. Mearnsii</i> bark were shown to improve postprandial glycemia and hence may be preferably beneficial for individuals with IGT with increasing muscle insulin resistance. <i>Elaeis guineensis</i> leaf was observed to improve both fasting and postprandial glycemic measures depending on the dose. Current evidence remains scarce regarding the impact of the plant extracts on glycemic control in prediabetes subgroups and therefore warrants further study.
format	article
author	Wen Xin Janice Lim Cheryl S. Gammon Pamela von Hurst Lynne Chepulis Rachel A. Page
author_facet	Wen Xin Janice Lim Cheryl S. Gammon Pamela von Hurst Lynne Chepulis Rachel A. Page
author_sort	Wen Xin Janice Lim
title	A Narrative Review of Human Clinical Trials on the Impact of Phenolic-Rich Plant Extracts on Prediabetes and Its Subgroups
title_short	A Narrative Review of Human Clinical Trials on the Impact of Phenolic-Rich Plant Extracts on Prediabetes and Its Subgroups
title_full	A Narrative Review of Human Clinical Trials on the Impact of Phenolic-Rich Plant Extracts on Prediabetes and Its Subgroups
title_fullStr	A Narrative Review of Human Clinical Trials on the Impact of Phenolic-Rich Plant Extracts on Prediabetes and Its Subgroups
title_full_unstemmed	A Narrative Review of Human Clinical Trials on the Impact of Phenolic-Rich Plant Extracts on Prediabetes and Its Subgroups
title_sort	narrative review of human clinical trials on the impact of phenolic-rich plant extracts on prediabetes and its subgroups
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/9034910e4eae41b88bafc44d166d466a
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A Narrative Review of Human Clinical Trials on the Impact of Phenolic-Rich Plant Extracts on Prediabetes and Its Subgroups

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