Plasmepsin II–III copy number accounts for bimodal piperaquine resistance among Cambodian Plasmodium falciparum

Plasmepsin II–III copy number accounts for bimodal piperaquine resistance among Cambodian Plasmodium falciparum

Piperaquine (PPQ) resistance of Plasmodium is an increasing problem. Here, Bopp et al. find a bimodal dose−response curve of Cambodian isolates exposed to PPQ, with the area under the curve correlating with in vitro PPQ resistance, and show the importance of Plasmepsin II–III copy number to PPQ resi...

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Autores principales: Selina Bopp, Pamela Magistrado, Wesley Wong, Stephen F. Schaffner, Angana Mukherjee, Pharath Lim, Mehul Dhorda, Chanaki Amaratunga, Charles J. Woodrow, Elizabeth A. Ashley, Nicholas J. White, Arjen M. Dondorp, Rick M. Fairhurst, Frederic Ariey, Didier Menard, Dyann F. Wirth, Sarah K. Volkman
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Q
Acceso en línea:https://doaj.org/article/9034c4b32e45414b8abd12e3feb18d67
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spelling oai:doaj.org-article:9034c4b32e45414b8abd12e3feb18d672021-12-02T17:32:44ZPlasmepsin II–III copy number accounts for bimodal piperaquine resistance among Cambodian Plasmodium falciparum10.1038/s41467-018-04104-z2041-1723https://doaj.org/article/9034c4b32e45414b8abd12e3feb18d672018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04104-zhttps://doaj.org/toc/2041-1723Piperaquine (PPQ) resistance of Plasmodium is an increasing problem. Here, Bopp et al. find a bimodal dose−response curve of Cambodian isolates exposed to PPQ, with the area under the curve correlating with in vitro PPQ resistance, and show the importance of Plasmepsin II–III copy number to PPQ resistance.Selina BoppPamela MagistradoWesley WongStephen F. SchaffnerAngana MukherjeePharath LimMehul DhordaChanaki AmaratungaCharles J. WoodrowElizabeth A. AshleyNicholas J. WhiteArjen M. DondorpRick M. FairhurstFrederic ArieyDidier MenardDyann F. WirthSarah K. VolkmanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Selina Bopp
Pamela Magistrado
Wesley Wong
Stephen F. Schaffner
Angana Mukherjee
Pharath Lim
Mehul Dhorda
Chanaki Amaratunga
Charles J. Woodrow
Elizabeth A. Ashley
Nicholas J. White
Arjen M. Dondorp
Rick M. Fairhurst
Frederic Ariey
Didier Menard
Dyann F. Wirth
Sarah K. Volkman
Plasmepsin II–III copy number accounts for bimodal piperaquine resistance among Cambodian Plasmodium falciparum
description Piperaquine (PPQ) resistance of Plasmodium is an increasing problem. Here, Bopp et al. find a bimodal dose−response curve of Cambodian isolates exposed to PPQ, with the area under the curve correlating with in vitro PPQ resistance, and show the importance of Plasmepsin II–III copy number to PPQ resistance.
format article
author Selina Bopp
Pamela Magistrado
Wesley Wong
Stephen F. Schaffner
Angana Mukherjee
Pharath Lim
Mehul Dhorda
Chanaki Amaratunga
Charles J. Woodrow
Elizabeth A. Ashley
Nicholas J. White
Arjen M. Dondorp
Rick M. Fairhurst
Frederic Ariey
Didier Menard
Dyann F. Wirth
Sarah K. Volkman
author_facet Selina Bopp
Pamela Magistrado
Wesley Wong
Stephen F. Schaffner
Angana Mukherjee
Pharath Lim
Mehul Dhorda
Chanaki Amaratunga
Charles J. Woodrow
Elizabeth A. Ashley
Nicholas J. White
Arjen M. Dondorp
Rick M. Fairhurst
Frederic Ariey
Didier Menard
Dyann F. Wirth
Sarah K. Volkman
author_sort Selina Bopp
title Plasmepsin II–III copy number accounts for bimodal piperaquine resistance among Cambodian Plasmodium falciparum
title_short Plasmepsin II–III copy number accounts for bimodal piperaquine resistance among Cambodian Plasmodium falciparum
title_full Plasmepsin II–III copy number accounts for bimodal piperaquine resistance among Cambodian Plasmodium falciparum
title_fullStr Plasmepsin II–III copy number accounts for bimodal piperaquine resistance among Cambodian Plasmodium falciparum
title_full_unstemmed Plasmepsin II–III copy number accounts for bimodal piperaquine resistance among Cambodian Plasmodium falciparum
title_sort plasmepsin ii–iii copy number accounts for bimodal piperaquine resistance among cambodian plasmodium falciparum
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/9034c4b32e45414b8abd12e3feb18d67
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