Plasmepsin II–III copy number accounts for bimodal piperaquine resistance among Cambodian Plasmodium falciparum
Piperaquine (PPQ) resistance of Plasmodium is an increasing problem. Here, Bopp et al. find a bimodal dose−response curve of Cambodian isolates exposed to PPQ, with the area under the curve correlating with in vitro PPQ resistance, and show the importance of Plasmepsin II–III copy number to PPQ resi...
Enregistré dans:
Auteurs principaux: | Selina Bopp, Pamela Magistrado, Wesley Wong, Stephen F. Schaffner, Angana Mukherjee, Pharath Lim, Mehul Dhorda, Chanaki Amaratunga, Charles J. Woodrow, Elizabeth A. Ashley, Nicholas J. White, Arjen M. Dondorp, Rick M. Fairhurst, Frederic Ariey, Didier Menard, Dyann F. Wirth, Sarah K. Volkman |
---|---|
Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2018
|
Sujets: | |
Accès en ligne: | https://doaj.org/article/9034c4b32e45414b8abd12e3feb18d67 |
Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
Documents similaires
-
Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine
par: Leila S. Ross, et autres
Publié: (2018) -
To what extent are the antimalarial markets in African countries ready for a transition to triple artemisinin-based combination therapies?
par: Freek de Haan, et autres
Publié: (2021) -
Proximate Composition of Thai and Cambodian Ready-to-Eat Insects
par: N. T. Grabowski, et autres
Publié: (2021) -
Optimal dosing of dihydroartemisinin-piperaquine for seasonal malaria chemoprevention in young children
par: Palang Chotsiri, et autres
Publié: (2019) -
Inhibition of Plasmepsin V activity demonstrates its essential role in protein export, PfEMP1 display, and survival of malaria parasites.
par: Brad E Sleebs, et autres
Publié: (2014)